Abstract:
:The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with thrombocytopenia, hypofibinogenaemia, and multiple coagulation defects, and with abnormally prolonged partial thromboplastin,prothombin, and thrombin times]. A second goups of 16 patients (7 fatal) showed a less severe grade of DIC manifested by thrombocytopenia, low fibringoen level, and a clotting factor defect shown by rpolonged prothrombin and thrombin times.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Hassanein EA,Tankovsky Idoi
10.1136/adc.50.4.308subject
Has Abstractpub_date
1975-04-01 00:00:00pages
308-10issue
4eissn
0003-9888issn
1468-2044journal_volume
50pub_type
杂志文章abstract::It has been suggested that because of vascular interchange between the monozygous twins vascular disruptions from a deceased cotwin with disseminated intravascular coagulation causes embolisation in the surviving twin. This study reports six cases in which all the surviving monozygous twins had central nervous system ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.454
更新日期:1986-05-01 00:00:00
abstract::The lactulose/L-rhamnose urinary excretion ratio during continued infusion of milks containing both sugars was used as an index of the permeability of the neonatal bowel to large and small molecules. Healthy infants of gestational age 31-36 weeks proved to have a period of enhanced permeability to lactulose during the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.2.141
更新日期:1982-02-01 00:00:00
abstract::Renal sodium handling was studied in 23 children at three different stages of the minimal change nephrotic syndrome--the oedema forming state, proteinuric steady state, and remission. Clearances of inulin and para-aminohippuric acid and urinary sodium excretion were determined basally, after intravenous infusion of is...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.9.825
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To determine if exploratory factor analysis can identify subtypes comprising recognisable clinical patterns of the presenting signs and symptoms of children with joint hypermobility syndrome (JHS). PATIENTS:Eighty-nine children with JHS aged 6-16 years. METHODS:Twelve tests comprising anthropometric, muscul...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305304
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.6.540
更新日期:1998-06-01 00:00:00
abstract:AIM:To produce a growth reference for British children with Williams syndrome. METHODS:The children and adults recruited into the study were all affiliated to the Williams Syndrome Foundation, a parent support group founded in 1979. They have all been shown to have a deletion of chromosome 7q11.23. One growth nurse (W...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.107946
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. DESIGN:Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. SETTING:Six UK paediat...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/adc.2006.115493
更新日期:2007-11-01 00:00:00
abstract::The effect of indomethacin treatment of patent ductus arteriosus (PDA) on blood pressure was studied in 24 preterm infants. PDA was diagnosed clinically and confirmed by echocardiography; the effect of treatment was monitored echocardiographically. Hourly intra-arterial recordings of systolic, diastolic, and mean bloo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5_spec_no.584
更新日期:1993-05-01 00:00:00
abstract::A study was performed to compare adverse events and antibody response in term and preterm children vaccinated with diphtheria, tetanus, and pertussis vaccine at 2, 3, and 4 months of age. A total of 124 children were recruited and grouped according to gestational age: 37 weeks or more (n = 52), 34 to 36 weeks (n = 40)...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.3.230
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Human metapneumovirus (hMPV) causes lower respiratory tract infections, particularly in young children and the elderly. METHODS:A prospective study was conducted on the clinical characteristics of infants <2 years of age admitted to hospital for respiratory infection and the characteristics of hMPV infectio...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.082388
更新日期:2006-04-01 00:00:00
abstract::The role of budesonide in controlling chest symptoms in infants was assessed. It was administered from a metered dose inhaler into a large volume spacer (Nebuhaler) with attached Laerdal mask. Twenty nine infants were recruited into a double blind crossover trial. Five defaulted. The remaining 24 (mean age 11 months) ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.67.3.285
更新日期:1992-03-01 00:00:00
abstract::The recent epidemic of childhood obesity(1) has raised concern because of the possible clinical and public health consequences.(2,)(3) However, there remains a widespread perception among health professionals that childhood obesity is a largely cosmetic problem, with minor clinical effects. No systematic review has ye...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/adc.88.9.748
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Short-course oral corticosteroids are commonly used in children but are known to be associated with adverse drug reactions (ADRs). This review aimed to identify the most common and serious ADRs and to determine their relative risk levels. METHODS:A literature search of EMBASE, MEDLINE, International Pharmac...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2015-309522
更新日期:2016-04-01 00:00:00
abstract::Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.4.314
更新日期:1977-04-01 00:00:00
abstract:OBJECTIVES:To describe the clinical presentation and sequelae, including salt-wasting crises of newly-diagnosed congenital adrenal hyperplasia (CAH) in children aged over 1 year in a contemporary population without screening. To appraise the potential benefit of newborn screening for late-presenting CAH. DESIGN:Active...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-303070
更新日期:2014-01-01 00:00:00
abstract::Blood lead concentrations and body iron status were investigated in 279 children. Blood lead concentrations showed no increase during iron depletion phase (stage I) but markedly increased from the phase of iron deficient erythropoiesis (stage II). Increased blood lead concentrations in anaemic subjects significantly d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.9.791
更新日期:2003-09-01 00:00:00
abstract::Urinary lithogenic and inhibitory factors were studied in 27 preterm infants; 16 had total parenteral nutrition (TPN) and 11 had breastmilk with an additional glucose-sodium chloride infusion. Urines were collected for 24 hours on day 2 (period A), day 3 (B), and once between days 4 and 10 (C). Urinary calcium oxalate...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.3_spec_no.299
更新日期:1993-09-01 00:00:00
abstract:RATIONALE:Accurate weight measurements are essential for both growth monitoring and drug dose calculations in children. Weight can be accurately measured using calibrated scales in resource-rich settings; however, reliable scales are often not available in resource-poor regions or emergency situations. Current age and/...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-309645
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJECTIVE:To test the ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.5.443
更新日期:1999-05-01 00:00:00
abstract::The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to 1990, 1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK were treated on MRC UKALL X with intensive...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/adc.74.2.101
更新日期:1996-02-01 00:00:00
abstract:AIM:To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. METHODS:A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using cla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312238
更新日期:2017-08-01 00:00:00
abstract::If cord blood IgE is used to detect those predisposed to become allergic it is important to define appropriately the normal values for this measurement. A commonly cited cut off point is 1.0 IU/ml. We analysed 5353 cord blood samples for IgE by means of an enzyme linked immunosorbent assay. Descriptive statistics of t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.5.478
更新日期:1987-05-01 00:00:00
abstract::A combined test of anterior pituitary function was used on 21 normal children. It shows that a comprehensive evaluation can be made of growth hormone, thyroid stimulating hormone, adrenocorticotrophic hormone, and gonadotrophin reserve. Simultaneous assessment of those peripheral glands associated with the anterior pi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.4.301
更新日期:1978-04-01 00:00:00
abstract::This paper reviews the diagnostic features of cluster headache-like disorder and describes its presentation in childhood. Case note summaries of patients with this condition are presented in the context of a brief summary of the literature. Four patients (two girls; aged 12 to 15 years) with cluster headache-like diso...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.6.511
更新日期:1999-12-01 00:00:00
abstract:INTRODUCTION:Propylene glycol (PG) is an unintentional frequently administered solvent in neonates despite the fact that PG accumulation potentially results in hyperosmolarity, lactic acidosis and renal/hepatic toxicity. METHODS:Prospective evaluation of renal (diuresis, creatinaemia, sodium), metabolic (base excess, ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.2010.190330
更新日期:2010-12-01 00:00:00
abstract::In 1973 a survey was conducted among 12 year old children living in a defined area of South Wales. In 1988 the survey was repeated in the same area, again among 12 year old children. Questionnaires were completed for all 965 children in the population sample; peak expiratory flow rates were performed on them all, and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.10.1452
更新日期:1989-10-01 00:00:00
abstract::Concentrations of chorionic somatomammotrophin (hCS) in maternal plasma at the time of delivery and in placental extracts were determined by radioimmunoassay and related to neonatal growth in 111 normal pregnancies. Mean maternal plasma hCS concentration was lower in association with small-for-dates infants, defined b...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.2.120
更新日期:1976-02-01 00:00:00
abstract:OBJECTIVE:Poor condition at birth may impact on IQ, although its effect on other measures of neurodevelopment is unclear. The authors' aim was to determine whether infants receiving resuscitation after birth have reduced scores in measures of attention, memory and language skills or the need for educational support at ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2009.176065
更新日期:2011-01-01 00:00:00
abstract::After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.53.8.660
更新日期:1978-08-01 00:00:00
abstract::Circulating erythroid progenitors (BFU-E) in five anaemic preterm infants (haemoglobin less than 100 g/l) were about 2 and 4.4 times as abundant as in 10 preterm infants who were not anaemic and five healthy adults, respectively, and were significantly more responsive to low concentrations of recombinant human erythro...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.7_spec_no.810
更新日期:1991-07-01 00:00:00