Abstract:
BACKGROUND:Human metapneumovirus (hMPV) causes lower respiratory tract infections, particularly in young children and the elderly. METHODS:A prospective study was conducted on the clinical characteristics of infants <2 years of age admitted to hospital for respiratory infection and the characteristics of hMPV infections were compared with those of infections caused by respiratory syncytial virus (RSV). Influenza A, B and C viruses, RSV, parainfluenza viruses, and adenoviruses were simultaneously detected in clinical samples by multiple reverse transcription nested-PCR assay. The presence of hMPV was tested in all samples using two separate RT-PCR tests. RESULTS:A respiratory virus was detected in 65.9% of the 749 children included in the study. hMPV, found in 69 of the positive nasopharyngeal aspirates (14%), was the most common virus after RSV. Peak incidence was in March and over 80% of children were <12 months of age. The most common diagnoses were recurrent wheezing (49.3%) and bronchiolitis (46.4%). Oxygen therapy was required by 58% of patients, and assisted ventilation by one. Clinical characteristics in the 18 co-infections were indistinguishable from those of single infections. Fifty one hMPV single infections were compared with 88 hRSV single infections. Recurrent wheezing was diagnosed more frequently in hMPV patients. All other variables tested were similar in both groups. CONCLUSIONS:hMPV was the second most frequent virus after RSV in infants <2 years of age hospitalised for respiratory infection and was associated with lower respiratory tract infections. hMPV occurred predominantly in springtime. Co-infections were frequent and clinically similar to single infections and RSV infections.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
García-García ML,Calvo C,Martín F,Pérez-Breña P,Acosta B,Casas Idoi
10.1136/adc.2005.082388subject
Has Abstractpub_date
2006-04-01 00:00:00pages
290-5issue
4eissn
0003-9888issn
1468-2044pii
adc.2005.082388journal_volume
91pub_type
杂志文章abstract::Quantitative biochemical criteria for lung growth and maturation were compared with the histological appearances in hypoplastic lungs from 20 fetuses and newborn infants. Cases associated with oligohydramnios showed a characteristic series of changes with narrow airways, retardation of epithelial and interstitial grow...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.8.606
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abstract:OBJECTIVES:(1) To determine the prevalence of cough, wheeze, and breathlessness, both as single symptoms and in combination, in primary schoolchildren and their relation to doctor diagnosed asthma. (2) To identify in areas with different levels of dust pollution whether questionnaire reported 'cough alone' (without whe...
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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更新日期:2009-04-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.3.408
更新日期:1993-03-01 00:00:00
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journal_title:Archives of disease in childhood
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更新日期:1989-03-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.79.2.161
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.4.301
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.62.5.478
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更新日期:1992-02-01 00:00:00
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doi:10.1136/adc.2009.179275
更新日期:2010-10-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,实务指引
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1136/adc.60.3.263
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更新日期:2003-12-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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journal_title:Archives of disease in childhood
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更新日期:2021-01-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.297
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
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更新日期:1998-02-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
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更新日期:1979-07-01 00:00:00