Risk of skin cancer after neonatal phototherapy: retrospective cohort study.

Abstract:

OBJECTIVE:To assess the risk of skin cancer in persons treated with neonatal phototherapy (NNPT) for jaundice. DESIGN:Retrospective cohort study. SETTING:Grampian Region, Scotland, UK. DATA SOURCE:Aberdeen Maternity and Neonatal Databank. NNPT exposure was abstracted from paper records spanning 1976-1990. Follow-up to 31 December 2006 by linkage to cancer registration and mortality records. MAIN OUTCOME MEASURES:Incidence ratios, standardised for age, sex, calendar period and socio-economic position. RESULTS:After excluding neonatal deaths (n=435), the cohort comprised 77,518 persons. 5868 Received NNPT, providing 138,000 person-years at risk (median follow-up, 24 years). Two cases of melanoma occurred in persons exposed to NNPT versus 16 cases in unexposed persons, yielding a standardised incidence ratio of 1.40 (95% CI, 0.17 to 5.04; p=0.834). No cases of squamous cell or basal cell carcinoma of skin were observed in exposed persons. CONCLUSIONS:Although there is no statistically significant evidence of an excess risk of skin cancer following NNPT, limited statistical power and follow-up duration mean it is not possible categorically to rule out an effect. However, taken in conjunction with the results of the only other study to investigate risk of melanoma following NNPT, evidence available so far does not suggest a major cause for concern.

journal_name

Arch Dis Child

authors

Brewster DH,Tucker JS,Fleming M,Morris C,Stockton DL,Lloyd DJ,Bhattacharya S,Chalmers JW

doi

10.1136/adc.2009.179275

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

826-31

issue

10

eissn

0003-9888

issn

1468-2044

pii

adc.2009.179275

journal_volume

95

pub_type

杂志文章
  • Quality of life of children and adolescents with chronic kidney disease: a cross-sectional study.

    abstract:OBJECTIVE:The aim was to compare quality of life (QoL) among children and adolescents with different stages of chronic kidney disease (CKD) and determine factors associated with changes in QoL. DESIGN:Cross-sectional. SETTING:The Kids with CKD study involved five of eight paediatric nephrology units in Australia and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2018-314934

    authors: Francis A,Didsbury MS,van Zwieten A,Chen K,James LJ,Kim S,Howard K,Williams G,Bahat Treidel O,McTaggart S,Walker A,Mackie F,Kara T,Nassar N,Teixeira-Pinto A,Tong A,Johnson D,Craig JC,Wong G

    更新日期:2019-02-01 00:00:00

  • Short stay facilities: the future of efficient paediatric emergency services.

    abstract::Many children admitted to hospital can stay for 24 hours or less. Short stay facilities offer such children rapid stabilisation and early discharge with considerable financial saving. A 12 month study was completed in which data were collected from the children's emergency annex (CEA) at Westmead Hospital in Sydney's ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.4.309

    authors: Browne GJ,Penna A

    更新日期:1996-04-01 00:00:00

  • Childhood and adolescent mental health of NICU graduates: an observational study.

    abstract:OBJECTIVE:To investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy. METHODS:This cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MI...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-318284

    authors: Chiorean A,Savoy C,Beattie K,El Helou S,Silmi M,Van Lieshout RJ

    更新日期:2020-07-01 00:00:00

  • Hypoparathyroidism and 22q11 deletion syndrome.

    abstract:AIMS:To investigate a population of individuals with 22q11 deletion syndrome for hypocalcaemia. METHODS:A detailed clinical history enquiring into symptoms of hypocalcaemia and blood sampling to assess for hypocalcaemia and hypoparathyroidism, of patients outside the neonatal period known to have the 22q11 microdeleti...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.6.520

    authors: Taylor SC,Morris G,Wilson D,Davies SJ,Gregory JW

    更新日期:2003-06-01 00:00:00

  • Disseminated intravascular clotting in kwashiorkor.

    abstract::The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.308

    authors: Hassanein EA,Tankovsky I

    更新日期:1975-04-01 00:00:00

  • Clostridial toxins in neonatal necrotising enterocolitis.

    abstract::Clostridium difficile cytopathic toxin was found in the faeces or gut content of five of 39 neonates with necrotising enterocolitis (NEC). Toxin concentrations were uniformly low and did not differ from those found in healthy neonates. C difficile is unlikely to be involved in the pathogenesis of NEC. Stools from 33 b...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.3.270

    authors: Thomas DF,Fernie DS,Bayston R,Spitz L

    更新日期:1984-03-01 00:00:00

  • Cockayne's syndrome and emphysema.

    abstract::A 5-year-old boy with Cockayne's syndrome is described. In addition to the recognised clinical features, he presented with severe fixed airways obstruction, and investigations confirmed clinical and physiological emphysema. In a disorder associated with many of the features of aging, it is probably that the presence o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.9.722

    authors: Cunningham M,Godfrey S,Moffat WM

    更新日期:1978-09-01 00:00:00

  • Service evaluation of laceration risk using trainer adrenaline auto-injectors.

    abstract:OBJECTIVE:Anaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2020-318898

    authors: Pike LC,Tuthill D

    更新日期:2021-01-01 00:00:00

  • HIV infection and in-hospital mortality at an academic hospital in South Africa.

    abstract:AIM:To document the impact that rapid increases in HIV infection in hospitalised children at Chris Hani Baragwanath Hospital has had on in-hospital mortality. METHODS:Hospital discharge summaries from January 1992 to the end of 1996 were reviewed. RESULTS:There were 20 733 admissions in the five year period; 7985 (39...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.83.3.227

    authors: Zwi K,Pettifor J,Soderlund N,Meyers T

    更新日期:2000-09-01 00:00:00

  • Achondroplasia Foramen Magnum Score: screening infants for stenosis.

    abstract:BACKGROUND:Achondroplasia is associated with foramen magnum stenosis (FMS) and significant risk of morbidity and sudden death in infants. A sensitive and reliable method of detecting infants who require decompressive surgery is required. This study aims to describe the incidence and severity of FMS in an unselected, se...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2020-319625

    authors: Cheung MS,Irving M,Cocca A,Santos R,Shaunak M,Dougherty H,Siddiqui A,Gringras P,Thompson D

    更新日期:2021-02-01 00:00:00

  • Coeliac disease associated with congenital heart disease.

    abstract::Six children with congenital heart disease are described in whom poor growth was found to be due to small-bowel villous atrophy; none was in heart failure and only one was severely cyanosed. Growth improved in all 6 on a gluten-free diet. Gluten enteropathy may be more common than is realised in children with congenit...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:

    authors: Congdon PJ,Fiddler GI,Littlewood JM,Scott O

    更新日期:1982-01-01 00:00:00

  • Interval between insulin injection and breakfast in diabetes.

    abstract::The relationship between the insulin-breakfast interval, postprandial increase in blood glucose, and glycaemic control was studied in 58 children with diabetes. Patients recorded insulin-breakfast intervals in a home diary over a seven day period, and during a 24 hour period at the weekend provided eight serial capill...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.3.248

    authors: Sackey AH,Jefferson IG

    更新日期:1994-09-01 00:00:00

  • Symmetrical thalamic lesions in infants.

    abstract::Clinical observations and findings on imaging are reported in six newborns with symmetrical thalamic lesions (STL). In three cases the diagnosis was confirmed by postmortem examination. Characteristic observations in this series and 17 previously reported cases include no evidence of perinatal asphyxia, high incidence...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.1_spec_no.15

    authors: Eicke M,Briner J,Willi U,Uehlinger J,Boltshauser E

    更新日期:1992-01-01 00:00:00

  • Preservation of somatostatin secretion in cystic fibrosis patients with diabetes.

    abstract::Immunohistochemical studies of pancreatic tissue from patients with cystic fibrosis associated with diabetes mellitus (CFDM) show increased numbers of somatostatin secreting delta cells. To look for a possible functional correlate to this finding basal and arginine stimulated plasma somatostatin and serum C peptide co...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1.123

    authors: Meacham LR,Caplan DB,McKean LP,Buchanan CN,Parks JS,Culler FL

    更新日期:1993-01-01 00:00:00

  • Trends in body mass index distribution and prevalence of thinness, overweight and obesity in two cohorts of Surinamese South Asian children in The Netherlands.

    abstract:OBJECTIVES:Asians have a smaller muscle mass and a larger fat mass at the same body mass index (BMI) than most other ethnic groups. Due to a resulting higher cardiometabolic risk, the BMI cut-offs for overweight and obesity were lowered for adults. For Asian children universal criteria apply. The objectives of this stu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303045

    authors: de Wilde JA,Zandbergen-Harlaar S,van Buuren S,Middelkoop BJ

    更新日期:2013-04-01 00:00:00

  • Sonographic long-term study: paediatric growth charts for single kidneys.

    abstract:AIMS:To explore the clinical course of children with "single kidney" (defined as either a solitary or single functioning kidney) with reference to renal function (glomerular filtration rate (GFR) and proteinuria), body height and particularly sonomorphological features. PATIENTS AND METHODS:This retrospective monocent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.153601

    authors: Spira EM,Jacobi C,Frankenschmidt A,Pohl M,von Schnakenburg C

    更新日期:2009-09-01 00:00:00

  • Choice of antibiotics in management of acute osteomyelitis and acute septic arthritis in children.

    abstract::A survey of 158 children with acute haematogenous osteomyelitis, and of 94 children with acute septic arthritis over an 8-year period was made to determine which bacteria cause these infections. In the osteomyelitis group the organism most frequently detected was Staphylococcus aureus (74% of cases). In 16% of cases s...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.9.679

    authors: Nade S

    更新日期:1977-09-01 00:00:00

  • Cisapride for gastro-oesophageal reflux and peptic oesophagitis.

    abstract::Twenty children (age range 75 days-47 months) with reflux oesophagitis entered a random double blind trial in which they received either Cisapride (Janssen Pharmaceutical Ltd), a new prokinetic agent, or an identical placebo syrup. Diagnosis of gastro-oesophageal reflux was made by measurement of intraluminal oesophag...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.62.5.454

    authors: Cucchiara S,Staiano A,Capozzi C,Di Lorenzo C,Boccieri A,Auricchio S

    更新日期:1987-05-01 00:00:00

  • Metabolic and hormonal responses of low birthweight infants to intravenously infused calories not exceeding the maintenance energy expenditure.

    abstract::Eithe low birthweight infants were studied for their metabolic and hormonal responses to intravenous alimentation when the caloric input was varied. The study was made during three consecutive 12-hour periods, when solutions of glucose, glucose and amino-acids, and glucose and amino-acid and lipids were successively i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.7.499

    authors: Rubecz I,Mestyán J,Varga P,Soltész G

    更新日期:1979-07-01 00:00:00

  • Encephalitis in children.

    abstract::Encephalitis is an uncommon but potentially devastating neurological syndrome with different aetiologies including direct central nervous system infection with different agents (most commonly viral) and those mediated by the immune system. Whilst there have been several recent publications and guidelines on the manage...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2011-300100

    authors: Thompson C,Kneen R,Riordan A,Kelly D,Pollard AJ

    更新日期:2012-02-01 00:00:00

  • Treatment related deaths during induction and in first remission in acute lymphoblastic leukaemia: MRC UKALL X.

    abstract::The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to 1990, 1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK were treated on MRC UKALL X with intensive...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/adc.74.2.101

    authors: Wheeler K,Chessells JM,Bailey CC,Richards SM

    更新日期:1996-02-01 00:00:00

  • Experiences of healthcare, including palliative care, of children with life-limiting and life-threatening conditions and their families: a longitudinal qualitative investigation.

    abstract:OBJECTIVES:To understand the experiences and perceptions of healthcare services of children with life-limiting and life-threatening conditions and their family members, including palliative care. DESIGN:Longitudinal qualitative interview study with children and their family members. Up to three in-depth interviews wer...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2020-320189

    authors: Mitchell S,Slowther AM,Coad J,Dale J

    更新日期:2020-11-16 00:00:00

  • Family resemblances of height, weight, and body fatness.

    abstract::In a study of 256 families, among whom were twins, midparent-adult son correlations for height, weight, and combined skinfold measurements were 0.67, 0.47, and 0.23 respectively. The corresponding midparent-adult daughter correlations were 0.63, 0.42, and 0.24. Midparent-growing offspring correlations were highest for...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.11.877

    authors: Hawk LJ,Brook CG

    更新日期:1979-11-01 00:00:00

  • Body composition in paediatric intestinal failure patients receiving long-term parenteral nutrition.

    abstract:OBJECTIVE:Outcome of children with intestinal failure (IF) has improved on treatment with parenteral nutrition (PN). The effects of PN and IF on body composition (BC) are unknown. The aim was to review BC in PN-treated children and those weaned off and to compare with reference data. DESIGN:Children on long-term/home ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303516

    authors: Pichler J,Chomtho S,Fewtrell M,Macdonald S,Hill S

    更新日期:2014-02-01 00:00:00

  • Cost implications of different approaches to the prevention of respiratory distress syndrome.

    abstract::Because the incidence of both neonatal respiratory distress syndrome and neonatal mortality can be reduced by giving corticosteroids to women expected to deliver preterm and by giving surfactant to babies at high risk of developing hyaline membrane disease, we have considered what effects the adoption of one or both o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.7_spec_no.757

    authors: Mugford M,Piercy J,Chalmers I

    更新日期:1991-07-01 00:00:00

  • Erythropoietin responsive progenitors in anaemia of prematurity.

    abstract::Circulating erythroid progenitors (BFU-E) in five anaemic preterm infants (haemoglobin less than 100 g/l) were about 2 and 4.4 times as abundant as in 10 preterm infants who were not anaemic and five healthy adults, respectively, and were significantly more responsive to low concentrations of recombinant human erythro...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.7_spec_no.810

    authors: Emmerson AJ,Westwood NB,Rackham RA,Stern CM,Pearson TC

    更新日期:1991-07-01 00:00:00

  • Psychiatric adverse drug reactions in the paediatric population.

    abstract:OBJECTIVE:Due to lack of information on drug use in children, many drugs are used off-label in paediatrics. Increased knowledge of adverse drug reactions (ADRs) would enable a better risk-benefit analysis. Our aim was to characterise drugs causing psychiatric ADRs in children by conducting a descriptive study based on ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317933

    authors: Ekhart C,Vries T,Hunsel FV

    更新日期:2020-08-01 00:00:00

  • Perineal sensation: an important predictor of long-term outcome in open spina bifida.

    abstract:OBJECTIVES:To see if perineal sensation in infants with open spina bifida is associated with a better long-term outcome, particularly in terms of survival, renal-related deaths and incontinence. METHODS:We conducted a prospective cohort study on a complete cohort of 117 consecutive patients with open spina bifida, who...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.102079

    authors: Oakeshott P,Hunt GM,Whitaker RH,Kerry S

    更新日期:2007-01-01 00:00:00

  • Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.

    abstract::The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.1.66

    authors: Alkalay A,Mogilner BM,Nissim F,Edelstein S

    更新日期:1983-01-01 00:00:00

  • Safety and ethics of bronchoscopy and endobronchial biopsy in difficult asthma.

    abstract:AIM:To investigate the safety of bronchoscopy and endobronchial biopsy in children with difficult asthma, and discuss the ethical issues associated with the procedure. METHODS:A three year prospective observational study was performed in two tertiary paediatric respiratory centres specialising in the management of chi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.84.5.423

    authors: Payne D,McKenzie SA,Stacey S,Misra D,Haxby E,Bush A

    更新日期:2001-05-01 00:00:00