Abstract:
:Immunohistochemical studies of pancreatic tissue from patients with cystic fibrosis associated with diabetes mellitus (CFDM) show increased numbers of somatostatin secreting delta cells. To look for a possible functional correlate to this finding basal and arginine stimulated plasma somatostatin and serum C peptide concentrations in eight insulin treated patients with cystic fibrosis and eight normal male controls were measured. Mean basal somatostatin concentrations were not different in the two groups. Mean peak somatostatin concentrations were significantly higher in the group with CFDM: 11.60 pmol/l v 7.14 pmol/l in controls. Mean peak C peptide concentrations were significantly lower in the group with cystic fibrosis: 0.89 nmol/l v 4.27 nmol/l in controls. This observation provides a physiological correlate to the pathological finding of increased somatostatin content in pancreatic tissue from patients with CFDM. Selective preservation of somatostatin secretion in patients with cystic fibrosis may further complicate pancreatic endocrine insufficiencies through paracrine inhibition of insulin and glucagon secretion.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Meacham LR,Caplan DB,McKean LP,Buchanan CN,Parks JS,Culler FLdoi
10.1136/adc.68.1.123subject
Has Abstractpub_date
1993-01-01 00:00:00pages
123-5issue
1eissn
0003-9888issn
1468-2044journal_volume
68pub_type
杂志文章abstract::Respiratory timing was studied in 100 babies ventilated for respiratory distress syndrome (RDS) during a brief period of continuous positive airway pressure. For the 76 spontaneously breathing babies the mean (SD) inspiratory and expiratory times were 0.31 (0.06) and 0.41 (0.12) seconds. Respiratory rate was predomina...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.4_spec_no.446
更新日期:1992-04-01 00:00:00
abstract::Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.2.111
更新日期:1998-02-01 00:00:00
abstract::Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rarely in the control ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.5.403
更新日期:1977-05-01 00:00:00
abstract::Since its first description optic nerve hypoplasia has been identified with increasing frequency, and a range of associated problems have been described. The major neurological and endocrine associations are well established, but those factors that predispose to the development of optic nerve hypoplasia remain unclear...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.103
更新日期:1990-01-01 00:00:00
abstract:AIMS:To document the patterns of presentation and outcome of severe anticholinesterase insecticide poisoning in children requiring intensive care. METHODS:Retrospective case note review of all 5541 children admitted to the paediatric intensive care unit (PICU) of a university hospital during the 10 years from January ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.5.352
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To describe current practice during stabilisation of children presenting with critical illness to the district general hospital (DGH), preceding retrieval to intensive care. DESIGN:Observational study using prospectively collected transport data. SETTING:A centralised intensive care retrieval service in Eng...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2008.151266
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To provide the first estimate of the cost-effectiveness of financial incentive for breastfeeding intervention compared with usual care. DESIGN:Within-cluster ('ward'-level) randomised controlled trial cost-effectiveness analysis (trial registration number ISRCTN44898617). SETTING:Five local authority distri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/archdischild-2018-316741
更新日期:2020-02-01 00:00:00
abstract::A protocol for the management of irritable hip was assessed; this protocol avoids hospital admission while detecting all other serious causes of hip pain, in particular septic arthritis, at the earliest possible opportunity. Fifty children with painful hips were studied prospectively with immediate ultrasound guided a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.2.110
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:The evidence base to guide the pharmacological management of tone and abnormal movements in cerebral palsy (CP) is limited, as is an understanding of routine clinical practice in the UK. We aimed to establish details of motor phenotype and current pharmacological management of a representative cohort across ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-316309
更新日期:2019-08-01 00:00:00
abstract::A cohort of 164 children born within the defined boundaries of greater Manchester during the years 1981 to 1984 inclusive were identified as having bilateral sensorineural hearing loss, giving a prevalence of 1.2/1000 population of 1/817 births. Ninety three children developed an additional conductive hearing loss sec...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.7.757
更新日期:1990-07-01 00:00:00
abstract:AIMS:To determine whether the British 1990 growth charts are valid for cross sectional and longitudinal use in primary school children. METHODS:A total of 694 children aged 7-10 years from 10 Leeds primary schools were weighed and measured annually over three years by an expert auxologist. SD scores were calculated us...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.4.298
更新日期:2000-10-01 00:00:00
abstract::A 5.7 year old boy with alpha 1-antitrypsin deficiency developed intractable ascites after liver transplantation. Conservative treatment was unsuccessful and after 18 days concentrated ascitic fluid was reinfused intravenously using a Gambro haemofilter. The ascitic loss resolved rapidly. This new method of ultrafiltr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.8.988
更新日期:1991-08-01 00:00:00
abstract::A retrospective analysis was made of the incidence and severity of the idiopathic respiratory distress syndrome (RDS) in babies of less than 35 weeks' gestation born at this hospital from January 1967-December 1974. There was a lower incidence of RDS in babies born after pregnancies complicated only by prolonged ruptu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.9.674
更新日期:1976-09-01 00:00:00
abstract::Cholelithiasis is considered uncommon in infancy, childhood, and adolescence. We performed a prospective, controlled study showing that children with Down's syndrome have a significantly higher prevalence of cholelithiasis (4.7%) compared with controls (0.2%). Clinicians should be aware of the risk of gallstones in ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.85.3.242
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The passage of hard stools is significantly more common in formula fed infants than breast fed infants and this might be the result of differences in fat absorption between breast and formula fed infants. Experimental studies indicate that long chain polyunsaturated fatty acids (LCPUFAs) might influence fat ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.81.3.253
更新日期:1999-09-01 00:00:00
abstract:AIM:To reduce the overall expenditure on melatonin for the local health economy by working collaboratively with the CCG's. To ensure that all paediatric patients prescribed melatonin have been clinically assessed by a specialist and the most appropriate formulation is dispensed. METHOD:Evaluation of GP melatonin presc...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.49
更新日期:2016-09-01 00:00:00
abstract::Urinary lithogenic and inhibitory factors were studied in 27 preterm infants; 16 had total parenteral nutrition (TPN) and 11 had breastmilk with an additional glucose-sodium chloride infusion. Urines were collected for 24 hours on day 2 (period A), day 3 (B), and once between days 4 and 10 (C). Urinary calcium oxalate...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.3_spec_no.299
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Heart murmurs are common in children, and they are often referred to a specialist for examination. A clinically innocent murmur does not need further investigation. The referral area of the University Hospital is large and sparsely populated. A new service for remote auscultation (telemedicine) of heart murm...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.4.297
更新日期:2002-10-01 00:00:00
abstract::Congenital haemolytic anaemia in a 14 year old girl was caused by increased red cell membrane cation permeability. Potassium permeability was unusually sensitive to hydrostatic pressure and treatment with N-ethylmaleimide, factors which activate a specific chloride dependent potassium channel in cell membranes. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.7.547
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVES:Healthy-weight children tend to gain weight during winter but lose weight during summer. However, overweight elementary school children have shown accelerated summertime weight gain. Whether this seasonal growth variation occurs during preschool period is of substantial interest. METHODS:Data were derived f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-314862
更新日期:2019-01-01 00:00:00
abstract::We have measured total work of breathing before and after the inhalation of water, salbutamol, and ipratropium bromide, given as nebulised solutions, in 39 studies on 25 infants with acute, severe bronchiolitis. Twenty minutes after nebulised water, mean work of breathing per minute was increased by 4% and work per li...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.58.4.279
更新日期:1983-04-01 00:00:00
abstract::Mechanisms of gastro-oesophageal reflux were studied by oesophageal manometry and pH monitoring in 33 children: nine controls, 15 with gastro-oesophageal reflux alone, and nine with reflux oesophagitis. A total of 122 episodes of reflux were analysed in detail: 82 (67%) were synchronous with swallowing and 40 (33%) as...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.11.1333
更新日期:1988-11-01 00:00:00
abstract::The clinical patterns of adverse reactions to cows' milk were examined in 72 children with cows' milk hypersensitivity. Two main groups were found, according to the time of onset of the adverse reaction--immediate onset, within one hour of milk ingestion and delayed onset, after one hour. Children with immediate onset...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.11.856
更新日期:1983-11-01 00:00:00
abstract::Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.064576
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that reduced fetal growth leads to altered plasma insulin-like growth factor-1 (IGF-1) concentrations in childhood. DESIGN:A follow up study of 4 year old children whose birth weights were recorded, and of 7 year old children whose weight, length, head circumference, and placental weig...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.73.4.287
更新日期:1995-10-01 00:00:00
abstract:AIM:To assess the value and safety of fasts for investigating hypoglycaemia or suspected metabolic disease. STUDY DESIGN:Review of all diagnostic fasts performed over a 2.5 year period. SETTING:The neonatal intensive care unit and programmed investigation unit at a tertiary referral centre for endocrinology and metab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.2.115
更新日期:1996-08-01 00:00:00
abstract::Monthly increments of length, weight gain, and head circumference were recorded from birth to 4 years of age in 52 children with cystic fibrosis. At birth the children showed stunting. Standard deviation (SD) scores at birth for height, weight, and head circumference were -1.24, -0.72, and -1.82 respectively. Over the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.2.150
更新日期:1995-02-01 00:00:00
abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.11.1100
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Clinical examination, while useful, has been shown to be insufficient as the sole screening method in infants. Ultrasound examination at 8 weeks in high risk infants is an integral part of the screening process in some units. AIMS:To show the efficiency of hip sonography in detection of developmental dyspla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.033597
更新日期:2005-06-01 00:00:00
abstract:RATIONALE:Studies suggest that increased breastfeeding rates can provide substantial financial savings, but the scale of such savings in the UK is not known. OBJECTIVE:To calculate potential cost savings attributable to increases in breastfeeding rates from the National Health Service perspective. DESIGN AND SETTINGS...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2014-306701
更新日期:2015-04-01 00:00:00