Pharmacological management of abnormal tone and movement in cerebral palsy.

Abstract:

BACKGROUND:The evidence base to guide the pharmacological management of tone and abnormal movements in cerebral palsy (CP) is limited, as is an understanding of routine clinical practice in the UK. We aimed to establish details of motor phenotype and current pharmacological management of a representative cohort across a network of UK tertiary centres. METHODS:Prospective multicentre review of specialist motor disorder clinics at nine UK centres, collecting data on clinical features and pharmacological management of children and young people (CYP) with CP over a single calendar month. RESULTS:Data were collected from 275 CYP with CP reviewed over the calendar month of October 2017. Isolated dystonia or spasticity was infrequently seen, with a mixed picture of dystonia and spasticity ± choreoathetosis identified in 194/275 (70.5%) of CYP. A comorbid diagnosis of epilepsy was present in 103/275 (37.4%). The most commonly used medications for abnormal tone/movement were baclofen, trihexyphenidyl, gabapentin, diazepam and clonidine. Medication use appeared to be influenced separately by the presence of dystonia or spasticity. Botulinum toxin use was common (62.2%). A smaller proportion of children (12.4%) had undergone a previous neurosurgical procedure for tone/movement management. CONCLUSIONS:CYP with CP frequently present with a complex movement phenotype and comorbid epilepsy. They have multiple therapy, medical and surgical management regimens. Future trials of therapeutic, pharmacological or surgical interventions in this population must adequately encompass this complexity in order to be translatable to clinical practice.

journal_name

Arch Dis Child

authors

Lumsden DE,Crowe B,Basu A,Amin S,Devlin A,DeAlwis Y,Kumar R,Lodh R,Lundy CT,Mordekar SR,Smith M,Cadwgan J

doi

10.1136/archdischild-2018-316309

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

775-780

issue

8

eissn

0003-9888

issn

1468-2044

pii

archdischild-2018-316309

journal_volume

104

pub_type

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