Abstract：
AIMS:To document the patterns of presentation and outcome of severe anticholinesterase insecticide poisoning in children requiring intensive care. METHODS:Retrospective case note review of all 5541 children admitted to the paediatric intensive care unit (PICU) of a university hospital during the 10 years from January 1990 to May 2000. Fifty four children (1%) with anticholinesterase insecticide poisoning were identified. Presenting features, route of exposure, treatment, complications, and mortality were recorded. Data were analysed by the Fisher's exact and Mann-Whitney tests. RESULTS:More children than expected were from a rural area (46% versus 25%). Decontamination occurred in 50% of children prior to PICU admission. Enteral exposure was most common (n = 27; 50%). Median pseudocholinesterase level was 185 IU/l (range 75-7404). Median total dose of atropine required to maintain mydriasis was 0.3 mg/kg (range 0.03-16.7) over a median of 10 hours (range 1-160). Complications included coma (31%), seizures (30%), shock (9%), arrhythmias (9%), and respiratory failure requiring ventilation (35%). No significant differences were detected in incidence of seizures, cardiac arrhythmias, respiratory failure, mortality, duration of ventilation, or PICU stay, according to route of exposure, or state of decontamination. Four children died (7%). Mortality was associated with the presence of a cardiac arrhythmia (likelihood ratio 8.3) and respiratory failure (likelihood ratio 3.3). CONCLUSION:The mortality and morbidity of severe anticholinesterase insecticide poisoning in childhood is not related to route of exposure, or to delay in decontamination. However, the presence of either a cardiac arrhythmia or respiratory failure is associated with a poor prognosis.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Verhulst L,Waggie Z,Hatherill M,Reynolds L,Argent Adoi
10.1136/adc.86.5.352subject
Has Abstractpub_date
2002-05-01 00:00:00pages
352-5issue
5eissn
0003-9888issn
1468-2044journal_volume
86pub_type
杂志文章abstract：:The temperatures of 587 children were taken before and after diphtheria/tetanus/pertussis (DTP) or diphtheria/tetanus (DT) vaccine. Only slight temperature increases were found but these were notably more frequent after plain than adsorbed DTP vaccine preparations and the frequency increased with each successive dose....
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.58.11.921
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive grow...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2015-310373
更新日期：2016-12-01 00:00:00
abstract：:The serum concentrations of tri-iodothyronine (T3), thyroxine (T4), and thyrotrophin (TSH) were measured in 10 term newborn infants between birth and the age of 2 days by radioimmunoassay. The mean concentration of T3 in maternal serum was 1.62 mug/l, and it increased from the low cord blood level of 0-63 mug/l to the...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.50.7.565
更新日期：1975-07-01 00:00:00
abstract：:In a 4-year period the neonatal survival rate for 26 infants weighing 501-750 g was 42% and for 81 infants weighing 751-1000 g it was 61%. All 59 surviving infants have been assessed at follow-up; 39 were at least 2 years old (corrected for prematurity) and data from the remaining 20 were derived from assessment at 1 ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.57.11.823
更新日期：1982-11-01 00:00:00
abstract：AIMS:To ascertain whether the reduction in nasopharyngeal carriage of vaccine serotypes induced by pneumococcal conjugate vaccine (PnCV) administered to infants persists beyond the age of 2 years. METHODS:Non-randomised, unblinded controlled study of 2-5 year old children who had received three doses of heptavalent Pn...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章
doi：10.1136/adc.88.3.211
更新日期：2003-03-01 00:00:00
abstract：:A postal survey of recently appointed consultant paediatricians was undertaken to determine whether they perceived their training had adequately equipped them for their current job. The response rate was 69% (207/299). After excluding replies from consultants trained outside the UK the analysis was carried out on 167 ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.71.4.381
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVE:To review the work of one tertiary paediatric palliative care service in facilitating planned withdrawal of ventilatory support outside the intensive care setting, with the purpose of developing local guidance for practice. METHODS:Retrospective 10-year (2003-2012) case note review of intensive care patients...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2013-305492
更新日期：2014-09-01 00:00:00
abstract：AIM:To measure drug adherence in children with mild asthma receiving long term prophylactic treatment. METHODS:Double blind randomised placebo controlled trial. Patients received inhaled budesonide 100 microg or 200 microg daily, or placebo for 27 months. All participants were asked to inhale medication or placebo fro...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1136/adc.83.4.330
更新日期：2000-10-01 00:00:00
abstract：:A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.50.2.153
更新日期：1975-02-01 00:00:00
abstract：:24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily blood pressure of healthy schoolchildren and on patients with hypertension. The subjects studied were 123 healthy schoolchildren with a mean (SD) age of 12.5 (1.6) years (range 9.5-14.5 years), 24 children with border...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.70.2.90
更新日期：1994-02-01 00:00:00
abstract：:Congenital haemolytic anaemia in a 14 year old girl was caused by increased red cell membrane cation permeability. Potassium permeability was unusually sensitive to hydrostatic pressure and treatment with N-ethylmaleimide, factors which activate a specific chloride dependent potassium channel in cell membranes. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.58.7.547
更新日期：1983-07-01 00:00:00
abstract：:Six children with congenital heart disease are described in whom poor growth was found to be due to small-bowel villous atrophy; none was in heart failure and only one was severely cyanosed. Growth improved in all 6 on a gluten-free diet. Gluten enteropathy may be more common than is realised in children with congenit...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some members of their families had a dominantly inherited risk of developing skin cancer and other serious problems. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.66.10_spec_no.1162
更新日期：1991-10-01 00:00:00
abstract：:Three cases of osteoid osteoma and one of benign osteoblastoma in children are described. The main complaint was severe pain which was worse at night; it was relieved by aspirin or other analgesics. The diagnosis was made on clinical and radiological grounds and was confirmed on histological examination of the central...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.54.6.459
更新日期：1979-06-01 00:00:00
abstract：:Serial recording in 45 low risk fetuses throughout the second and third trimesters showed that hiccups were the predominant diaphragmatic movement before 26 weeks' gestational age and that there was a significant negative correlation with gestational age. There was a pronounced reduction between 24 and 26 weeks, which...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.65.10_spec_no.1072
更新日期：1990-10-01 00:00:00
abstract：:In 20 children needing treatment for symptomatic sick sinus syndrome, the average age at presentation was 7.1 years and ranged from 9 months to 18 years. Symptoms were never precise but, in retrospect, 5 children had syncope, 7 had a rapid heart action, 6 had dyspnoea or tachypnoea, 2 had nonspecific chest pains, 2 ha...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.50.11.879
更新日期：1975-11-01 00:00:00
abstract：OBJECTIVE:Despite decreasing mortality, functional impairments in children with transposition of the great arteries (TGA) are still a concern. This study analyses health-related physical fitness (HRPF), arterial stiffness and health-related quality of life (HRQoL) in children with anatomically repaired TGA regarding co...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2018-316444
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether dual energy x-ray absorptiometry (DXA) and quantitative ultrasound (QUS) classify the same children as 'abnormal' (SD (z) score (SDS) ≤-2). METHODS:Speed of sound (SOS) was measured at the radius and tibia using QUS and lumbar spine bone mineral density (BMD) using DXA in 621 subjects age...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2011-301326
更新日期：2012-09-01 00:00:00
abstract：:A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy. The infant had dysmorphic features and was physically and mentally retarded. We consider that the malformations were the result of the maternal treatment with carbamazepine. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.66.5.641
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVES:To determine the incidence of insulin dependent diabetes mellitus (IDDM) among children aged up to 16 years residing in the city of Karachi, Pakistan, during the five years from 1989 to 1993. DESIGN:Retrospective study of incidence using hospital and clinic records. SETTING:The city of Karachi, Pakistan. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.76.2.121
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVE:To characterise fetal brain growth in children with specific language impairment (SLI). DESIGN:A nested case-control study. SETTING:Perth, Western Australia. PARTICIPANTS:Thirty children meeting criteria for SLI at age 10 years were individually matched with a typically developing comparison child on sex, ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2009.180331
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,多中心研究
doi：10.1136/archdischild-2017-313856
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:It is often assumed that prolonged time to diagnosis (TTD) for cancer negatively influences overall survival and survivorship through advanced stage disease at diagnosis. This systematic review assesses existing early diagnosis research in childhood and young adult cancer and aims to identify whether a consensu...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,评审
doi：10.1136/archdischild-2012-303034
更新日期：2013-05-01 00:00:00
abstract：AIM:To assess the value and safety of fasts for investigating hypoglycaemia or suspected metabolic disease. STUDY DESIGN:Review of all diagnostic fasts performed over a 2.5 year period. SETTING:The neonatal intensive care unit and programmed investigation unit at a tertiary referral centre for endocrinology and metab...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.75.2.115
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Congenital facial palsy (CFP) is clinically defined as facial palsy present at birth. It is associated with considerable disfigurement and causes functional and emotional problems for the affected child. The aetiology of the majority of cases however, remains elusive. AIMS:To investigate the role of a neuro...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.83.3.256
更新日期：2000-09-01 00:00:00
abstract：AIMS:To prospectively evaluate sinopulmonary disease in 24 patients with primary humoral immunodeficiency (11 with agammaglobulinaemia, nine with isolated IgA deficiency, and two with common variable immunodeficiency) and chronic productive cough, ascertain the usefulness of chest high resolution computed tomography (H...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.88.12.1101
更新日期：2003-12-01 00:00:00
abstract：:Determinations of body height and calculations of growth velocity are still the major parameters for the assessment of normal and aberrant growth. The present study was performed to investigate the minimum time interval between consecutive measurements that is necessary for a statement on significant length increment ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.64.2.259
更新日期：1989-02-01 00:00:00
abstract：:Spirometric data from 1586 healthy children, who did not smoke, were analysed to examine the effects of overweight as measured by the body mass index (weight/height2) on lung function. Overweight (72 boys, 88 girls) was defined as on or above the 90th percentile weight for height. After having controlled for the confo...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.65.5.512
更新日期：1990-05-01 00:00:00
abstract：:Advances in paediatric care mean that more children with complex medical problems (heart disease, neurodevelopmental problems and so on) are surviving their early years. This has important implications for the design and delivery of healthcare given their extensive multidisciplinary requirements and susceptibility to ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2019-317373
更新日期：2020-05-13 00:00:00
abstract：OBJECTIVES:To investigate the prevalence of infant crying and maternal soothing techniques in relation to ethnic origin and other sociodemographic variables. DESIGN:A questionnaire survey among mothers of 2-3 month old infants registered at six child health clinics in Amsterdam, the Netherlands. SUBJECTS:A questionna...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.79.4.312
更新日期：1998-10-01 00:00:00
