Cisapride for gastro-oesophageal reflux and peptic oesophagitis.

Abstract:

:Twenty children (age range 75 days-47 months) with reflux oesophagitis entered a random double blind trial in which they received either Cisapride (Janssen Pharmaceutical Ltd), a new prokinetic agent, or an identical placebo syrup. Diagnosis of gastro-oesophageal reflux was made by measurement of intraluminal oesophageal pH combined with manometry. Oesophagitis was assessed in all patients by histological examination of mucosal specimens taken during oesophagogastroduodenoscopy. Manometry, pH test, and endoscopy with biopsy examination were repeated at the end of the treatment period. Seventeen patients completed the trial, eight of whom were taking the drug and nine the placebo. Mean total clinical score and post-prandial reflux time (% of reflux) significantly improved in patients in the group given Cisapride but not in the group given placebo. Furthermore, there was a significant improvement of the histological oesophagitis score only in the children in the group given Cisapride, whereas placebo was ineffective. It is concluded that Cisapride is a useful agent both for the relief of symptoms of gastro-oesophageal reflux and for the healing of peptic oesophagitis in infancy.

journal_name

Arch Dis Child

authors

Cucchiara S,Staiano A,Capozzi C,Di Lorenzo C,Boccieri A,Auricchio S

doi

10.1136/adc.62.5.454

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

454-7

issue

5

eissn

0003-9888

issn

1468-2044

journal_volume

62

pub_type

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