Abstract：
OBJECTIVES:To see if perineal sensation in infants with open spina bifida is associated with a better long-term outcome, particularly in terms of survival, renal-related deaths and incontinence. METHODS:We conducted a prospective cohort study on a complete cohort of 117 consecutive patients with open spina bifida, whose backs were closed non-selectively at birth between 1963 and 1971. A meticulous neurological examination in infancy showed that 33 (28%) of them had perineal sensation, defined as intact sensation to pinprick in at least one dermatome on one side in the saddle area (S2-4). Data recorded within 48 h of birth and during six reviews between 1972 and 2002 were used. Details of deaths were obtained from medical records and from the Office of National Statistics. RESULTS:By December 2005, 57% (67/117) of the cohort had died. There were 50 survivors with a mean age 38 years (range 35-41). More of those with perineal sensation survived than those without (23/33 v 27/84, p<0.001). This difference was mainly caused by 19 renal deaths in those lacking perineal sensation. Crucially there were no renal-related deaths in those with perineal sensation (0/33 v 19/84, p = 0.003). Among the survivors, those with perineal sensation were more likely than the remainder to be continent of urine and faeces (10/23 v 1/27, p<0.001 and 18/23 v 9/27, p = 0.002 respectively). They were also more likely to be able to walk at least 50 m (11/23 v 5/27, p = 0.027) and never to have had pressure sores (15/23 v 9/27, p = 0.025). CONCLUSIONS:A simple assessment of perineal sensation in infancy predicts long-term outcome in terms of survival, renal prognosis and incontinence in open spina bifida.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Oakeshott P,Hunt GM,Whitaker RH,Kerry Sdoi
10.1136/adc.2006.102079subject
Has Abstractpub_date
2007-01-01 00:00:00pages
67-70issue
1eissn
0003-9888issn
1468-2044pii
adc.2006.102079journal_volume
92pub_type
杂志文章abstract：:The effect of raising the airways resistance of 56 normal newborn babies by blocking alternate nostrils was studied by means of oesophageal intubation and the trunk plethysmograph. Increased resistance was associated with reduced respiratory rate and ventilation. A comparison was made of the response in different slee...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.51.8.602
更新日期：1976-08-01 00:00:00
abstract：OBJECTIVE:To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment of Helicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day. STUDY DESIGN:252 patients (median age, 11.0 years; range, 3-...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1136/adc.81.1.68
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,多中心研究
doi：10.1136/archdischild-2017-313856
更新日期：2018-07-01 00:00:00
abstract：:After the introduction of the colposcope for the examination of children suspected of being sexually abused in Leeds, a study was undertaken to describe the findings in detail. A total of 109 consecutive prepubertal girls, mean age 70.4 months were assessed including colposcopic genital and anal examination, and peer ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.73.5.465
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVES:The amount of adipose tissue influences pubertal development and fertility in girls. A candidate for mediating this is the hormone leptin, derived from adipocytes. This work was carried out to determine whether the leptin concentration in serum is regulated during pubertal development. SUBJECTS AND METHODS:...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.77.5.396
更新日期：1997-11-01 00:00:00
abstract：:The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonar...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.66.12.1378
更新日期：1991-12-01 00:00:00
abstract：OBJECTIVE:To review the clinical features, treatment, and outcome of children in the UK with Down's syndrome and acute myeloid leukaemia (AML). DESIGN:A retrospective study of 59 children with Down's syndrome and AML presenting between 1987 and 1995. Data were obtained from hospital case notes, trial records, and by q...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.81.1.32
更新日期：1999-07-01 00:00:00
abstract：:Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,评审
doi：10.1136/adc.2004.064576
更新日期：2006-02-01 00:00:00
abstract：AIMS:To describe the clinical features, diagnosis and management of children with tuberculosis in the United Kingdom and Republic of Ireland. METHODS:Cases of culture-confirmed and clinically diagnosed tuberculosis were reported to the British Paediatric Surveillance Unit from December 2003 to January 2005. RESULTS:3...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,多中心研究
doi：10.1136/adc.2007.133645
更新日期：2009-04-01 00:00:00
abstract：:Three cases are reported in which thrombi were found in the aorta at postmortem. In each case the thrombus had originated within the ductus arteriosus. We believe that in recent years the attention paid to the presence of indwelling cannulae as a cause of embolic phenomena in the newborn period has led to a reduction ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.53.2.164
更新日期：1978-02-01 00:00:00
abstract：:This paper reviews the diagnostic features of cluster headache-like disorder and describes its presentation in childhood. Case note summaries of patients with this condition are presented in the context of a brief summary of the literature. Four patients (two girls; aged 12 to 15 years) with cluster headache-like diso...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.81.6.511
更新日期：1999-12-01 00:00:00
abstract：:In a prospective follow up of 116 high risk infants, a 24 hour behavioural chart on seven consecutive days was analysed at seven and 12 weeks of age. Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week t...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.84.4.349
更新日期：2001-04-01 00:00:00
abstract：:A retrospective analysis was made of the incidence and severity of the idiopathic respiratory distress syndrome (RDS) in babies of less than 35 weeks' gestation born at this hospital from January 1967-December 1974. There was a lower incidence of RDS in babies born after pregnancies complicated only by prolonged ruptu...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.51.9.674
更新日期：1976-09-01 00:00:00
abstract：:Endogenous formation of thromboxane A2 and prostacyclin were evaluated in seven neonatates with persistent pulmonary hypertension by serial gas chromatographic mass spectrometric determination of their urinary metabolites dinor-thromboxane B2 and dinor-6-keto-prostaglandin F1 alpha, respectively. The patients were stu...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.64.7_spec_no.949
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:Although antibiotics are recommended for the primary care management of community-acquired pneumonia, a recent UK study reported that most children admitted to hospital had not received antibiotics. OBJECTIVE:To describe primary care antibiotic use for children subsequently hospitalised with community-acqui...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2011-300604
更新日期：2012-01-01 00:00:00
abstract：:Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.60.8.752
更新日期：1985-08-01 00:00:00
abstract：:Twenty-seven children with unilateral proptosis were investigated over a period of 8 1/2 years. Seventeen (63%) of them had local or disseminated malignancy, a higher proportion than in earlier reports. The frequency of inflammatory lesions, particularly ethmoiditis progressing to proptosis, appeared to have decreased...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.56.7.549
更新日期：1981-07-01 00:00:00
abstract：INTRODUCTION:Despite immunisation, antibiotics and intensive care management, infection with Streptococcus pneumoniae remains a major cause of morbidity and mortality in children. The WHO currently recommends vaccinating infants with either a 3+0 schedule (6 weeks, 3-4 and 4-6 months of age) or 2+1 schedule (2 doses be...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,随机对照试验
doi：10.1136/archdischild-2018-316254
更新日期：2019-07-01 00:00:00
abstract：:A 14-month-old girl with invasive perineal amoebiasis is reported. There was destruction of the anus, the rectovaginal septum, the pelvic floor, and the perineum. The rapid progress and destructive potential of perineal amoebiasis is noted and the benefits of diagnostic awareness emphasised. Treatment with metronidazo...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.55.3.234
更新日期：1980-03-01 00:00:00
abstract：:The clinical patterns of adverse reactions to cows' milk were examined in 72 children with cows' milk hypersensitivity. Two main groups were found, according to the time of onset of the adverse reaction--immediate onset, within one hour of milk ingestion and delayed onset, after one hour. Children with immediate onset...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.58.11.856
更新日期：1983-11-01 00:00:00
abstract：:A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatme...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.53.4.308
更新日期：1978-04-01 00:00:00
abstract：:Breast fed infants may be at greater risk of mother to infant hepatitis B virus infection compared with formula fed infants. We studied 85 infants born to 84 hepatitis B surface antigen positive mothers (only two of whom were hepatitis B e positive), and who had received immunisation against hepatitis B virus. Our res...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.60.10.972
更新日期：1985-10-01 00:00:00
abstract：:Data drawn from the National Study of Health and Growth enabled an examination to be made of the attained height, weight for height, and triceps skinfold of children from one and two parent families. Children from one parent families were shorter than children from two parent families; however, once heights had been a...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.57.6.453
更新日期：1982-06-01 00:00:00
abstract：:The discovery of testicles in a 3-year-old girl with XY karyotype led to a diagnosis of testicular feminization. Subsequently, however, hypokalaemia, hypertension, and severe prostration during a mild infection suggested adrenal involvement, and investigations showed a 17-alpha-hydroxylase deficiency. Diagnosis of tes...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.51.9.721
更新日期：1976-09-01 00:00:00
abstract：:The poor prognosis of patients with trisomy 13 has long been accepted and has been ascribed to brain and heart malformations. It has been suggested, however, that the long term survival is better than was previously thought and that cardiac surgery may be justified. This population based study reviews the incidence, a...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.71.4.343
更新日期：1994-10-01 00:00:00
abstract：:Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was campared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-d...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章
doi：10.1136/adc.50.5.387
更新日期：1975-05-01 00:00:00
abstract：OBJECTIVES:Children's exposure to racism via caregiver experience (vicarious racism) is associated with poorer health and development. However, the relationship with child healthcare utilisation is unknown. We aimed to investigate (1) the prevalence of vicarious racism by child ethnicity; (2) the association between ca...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2017-313866
更新日期：2018-09-01 00:00:00
abstract：:The provision of positive end expiratory pressure, via a unique portable system, in the long term management of a child with thoracic dystrophy is reported. The system uses low gas flow enabling a reduction in equipment and simplification of the circuit as compared with a standard continuous positive airways pressure ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.67.1.136
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Cerebral palsy is the commonest cause of severe physical disability in childhood. For many years treatment has centred on the use of physiotherapy and orthotics to overcome the problems of leg spasticity, which interferes with walking and can lead to limb deformity. Intramuscular botulinum toxin (BT-A) offer...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1136/adc.83.6.481
更新日期：2000-12-01 00:00:00
abstract：:The use of the Bene-Anthony Family Relations Test is described and illustrated by three examples of child abuse. This test should be considered in the investigation of definite or suspected cases of abuse and as part of the preparation of court evidence. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.52.9.708
更新日期：1977-09-01 00:00:00
