Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial.

Abstract:

OBJECTIVE:To compare dual therapy (omeprazole and amoxicillin) with triple therapy (omeprazole, amoxicillin, and clarithromycin) in the treatment of Helicobacter pylori infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared with 2 mg/kg/day. STUDY DESIGN:252 patients (median age, 11.0 years; range, 3-18) presenting with chronic abdominal pain underwent endoscopy and a 13C-urea breath test. Gastric biopsy specimens were taken for histological examination and for the rapid urease test. Patients were treated for two weeks: group A (n = 63) received amoxicillin (50 mg/kg; maximum, 2 g/day), group B (n = 73) received amoxicillin and clarithromycin (20 mg/kg; maximum, 1 g/day). Both groups were randomly treated with either 1 or 2 mg/kg omeprazole (maximum, 80 mg/day). Diagnostic procedures were repeated four weeks after the end of treatment. RESULTS:11 patients were excluded; 136 patients were H pylori positive (56%), 105 of whom were re-examined after treatment. Helicobacter pylori was eradicated in 52% of group A and 83% of group B. The dose of omeprazole had no influence on the eradication rate. Specificity and sensitivity of the rapid urease test were 94% and 93%, respectively. Specificity and sensitivity of the 13C-urea breath test were 93% and 95%, respectively. CONCLUSIONS:Dual therapy can no longer be recommended. Triple therapy is more effective than dual therapy in the eradication of H pylori infection. The lower dose of 1 mg/kg omeprazole was as effective as 2 mg/kg.

journal_name

Arch Dis Child

authors

Behrens R,Lang T,Keller KM,Bindl L,Becker M,Rodeck B,Küster P,Wündisch GF,Stolte M

doi

10.1136/adc.81.1.68

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

68-70

issue

1

eissn

0003-9888

issn

1468-2044

journal_volume

81

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    更新日期:2002-03-01 00:00:00

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    更新日期:2013-10-01 00:00:00

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    更新日期:1998-04-01 00:00:00

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    journal_title:Archives of disease in childhood

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    更新日期:2000-01-01 00:00:00

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    更新日期:1995-08-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    doi:10.1136/adc.51.9.674

    authors: Chiswick ML

    更新日期:1976-09-01 00:00:00

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    doi:10.1136/adc.74.1.56

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    更新日期:1996-01-01 00:00:00

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    authors: Jones DR,Macintyre IM

    更新日期:1975-02-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

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    更新日期:2003-09-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

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