Neonatal hypocalcaemia associated with maternal hyperparathyroidism. New pathogenetic observations.

Abstract:

:A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatment with calcium and vitamin D, serum PTH and 25-OHD3 concentrations increased markedly before serum calcium levels returned to normal perhaps indicating an inability to convert 25-OHD3 to the metabolically active 1,25-dihyroxyvitamin D3 during the hyperphosphataemic state. Treatment with 1,25-dihdroxyvitamin D3 or its analogues is recommended.

journal_name

Arch Dis Child

authors

Jacobsen BB,Terslev E,Lund B,Sørensen OH

doi

10.1136/adc.53.4.308

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

308-11

issue

4

eissn

0003-9888

issn

1468-2044

journal_volume

53

pub_type

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