Abstract:
OBJECTIVE:Risk assessment for venous thromboembolism (VTE) and thromboprophylaxis in those with risk factors is established in adult practice. Evidence to support efficacy and safety of this approach in adolescents is lacking. We aimed to describe thrombotic risk factors and to determine the proportion of potentially preventable events in a retrospective cohort study of adolescents with VTE. DESIGN, SETTING AND PATIENTS:Data were collected between 2008 and 2014 from eight tertiary UK centres. Qualifying events were radiologically confirmed VTE in subjects aged 12-17 years. Central venous line-related upper venous system events were excluded. RESULTS:76 cases were identified, 41 males, median age 15 years. Frequent risk factors were: reduced mobility, 45%; thrombophilia, 24%; malignancy, 20%; surgery, 18%; combined oral contraceptive pill, 12%; congenital venous anomaly, 5%. 28 (37%) had no significant underlying diagnosis and no provoking event/hospitalisation, presenting as outpatients with VTE which was considered 'unpreventable'. Of 48 where there had been opportunity for risk assessment, chemical thromboprophylaxis was not indicated in 26 and was contraindicated in 8. 14/76 (18%) had an indication to consider thromboprophylaxis and no contraindication. Of these, four had cerebral palsy, five malignancy and two inflammatory bowel disease. All had reduced mobility with recent surgery in eight. Four received chemical thromboprophylaxis prior to presentation. CONCLUSIONS:Among a cohort of adolescents with VTE, a small proportion (13%) had an indication to consider chemical thromboprophylaxis but did not receive it. VTE risk assessment and prevention should focus on adolescents with immobility or surgery, particularly in those with malignancy.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Biss T,Alikhan R,Payne J,Alamelu J,Williams M,Richards M,Mathias M,Tunstall O,Chalmers Edoi
10.1136/archdischild-2015-309875subject
Has Abstractpub_date
2016-05-01 00:00:00pages
427-32issue
5eissn
0003-9888issn
1468-2044pii
archdischild-2015-309875journal_volume
101pub_type
杂志文章,多中心研究abstract::A previously described difference in newborn blood phenylalanine concentrations between those living in urban and non-urban areas in the south west of England has been confirmed and shown to be independent of the type of feed. Several factors including the place of abode, type of feed, birthweight, and the accuracy of...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.4.271
更新日期:1983-04-01 00:00:00
abstract::The effect on deep body temperature of infants co-sleeping (with either or both parents) is investigated in this case control study. Overnight continuous recordings of rectal temperature were made from 34 babies co-sleeping with one or both parents throughout the night and 34 infants matched for age, feeding regimen, ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.3.249
更新日期:1996-09-01 00:00:00
abstract::Five cases are reported of spontaneous remission of chronic childhood thrombocytopenia four or more years after diagnosis. Other than typical features of chronic idiopathic thrombocytopenic purpura there were no obvious markers predictive of late remission, although a slow progressive recovery was common to four of th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5.680
更新日期:1993-05-01 00:00:00
abstract::Published reports on the treatment of large strawberry naevi have been reviewed. It is suggested that they should normally be left untreated, and that corticosteroids, given for a short period only, should be reserved for massive naevi close to the eye, or interfering with respiration or suckling, or associated with t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.51.2.138
更新日期:1976-02-01 00:00:00
abstract::The poor prognosis of patients with trisomy 13 has long been accepted and has been ascribed to brain and heart malformations. It has been suggested, however, that the long term survival is better than was previously thought and that cardiac surgery may be justified. This population based study reviews the incidence, a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.343
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES:Congenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life. METHODS:Twen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308450
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:In 1999, invasive meningococcal disease was hyperendemic in Ireland at 14.75/100 000 population, with 60% group B and 30% group C diseases. National sepsis guidelines and meningococcal C vaccines were introduced in 2000. Despite a spontaneous decline in group B infection, invasive meningococcal disease remai...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2015-310215
更新日期:2016-12-01 00:00:00
abstract::A retrospective analysis was made of the incidence and severity of the idiopathic respiratory distress syndrome (RDS) in babies of less than 35 weeks' gestation born at this hospital from January 1967-December 1974. There was a lower incidence of RDS in babies born after pregnancies complicated only by prolonged ruptu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.9.674
更新日期:1976-09-01 00:00:00
abstract::Forty six of 142 infants weighing less than 1500 g at birth, who had chest radiographs in the first 5 days of life, developed pulmonary interstitial emphysema (PIE) and in 19 this occurred in the first 24 hours. PIE was seen more frequently in infants weighing less than 1000 g at birth (24 of 57) than in those weighin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.8.612
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVES:Despite improved nutrition and intensive treatment, subjects with cystic fibrosis have difficulty in maintaining anabolism during intercurrent infections, which can result in reduced body mass index and impaired skeletal growth. Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP3 are sensitiv...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.76.4.304
更新日期:1997-04-01 00:00:00
abstract:AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.4
更新日期:2016-09-01 00:00:00
abstract::Six children with congenital heart disease are described in whom poor growth was found to be due to small-bowel villous atrophy; none was in heart failure and only one was severely cyanosed. Growth improved in all 6 on a gluten-free diet. Gluten enteropathy may be more common than is realised in children with congenit...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:AIM:To determine the incidence of hypocalcaemia in critically ill children with meningococcal disease. METHODS:In a prospective cohort study, 70 of 80 patients admitted consecutively with a clinical diagnosis of meningococcal disease to intensive care had measurements of total and ionised calcium on admission. Paratho...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.6.510
更新日期:2000-12-01 00:00:00
abstract::The effect of indomethacin treatment of patent ductus arteriosus (PDA) on blood pressure was studied in 24 preterm infants. PDA was diagnosed clinically and confirmed by echocardiography; the effect of treatment was monitored echocardiographically. Hourly intra-arterial recordings of systolic, diastolic, and mean bloo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5_spec_no.584
更新日期:1993-05-01 00:00:00
abstract::In this overview, I have attempted to highlight the problems of medical care, particularly paediatric care, in Hungary and to describe the changing nature of its organisation and financing. We hope that through our efforts we can surmount these difficulties, improve the quality of medical care in our country, and crea...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.8.1042
更新日期:1992-08-01 00:00:00
abstract::The National Grid is a training scheme that represents a unique partnership between Deaneries and the Royal College of Paediatrics and Child Health (RCPCH) in offering through national competition, equitable access to high quality subspecialty training. Paediatrics is unusual in that within the umbrella Certificate of...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.066688
更新日期:2006-01-01 00:00:00
abstract::The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.4.339
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To compare a comprehensive lifestyle intervention for overweight children performed in groups of families with a conventional single-family treatment. Two-year follow-up data on anthropometric and psychological outcome are presented. DESIGN:Overweight and obese children aged 6-12 years with body mass index (...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/archdischild-2014-307107
更新日期:2015-05-01 00:00:00
abstract::Fifty nine preterm infants of between 1.0 and 2.0 kg birthweight who were fed 250 ml/kg/day of breast milk or standard formulas gained weight at the intrauterine rate without complications. It is suggested that high volume feeding is a satisfactory alternative to low birthweight formula milks and is more desirable in ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.8.779
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:Use next-generation sequencing (NGS) technology to improve our diagnostic yield in patients with suspected genetic disorders in the Asian setting. DESIGN:A diagnostic study conducted between 2014 and 2019 (and ongoing) under the Singapore Undiagnosed Disease Program. Date of last analysis was 1 July 2019. S...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319180
更新日期:2021-01-01 00:00:00
abstract::Monthly increments of length, weight gain, and head circumference were recorded from birth to 4 years of age in 52 children with cystic fibrosis. At birth the children showed stunting. Standard deviation (SD) scores at birth for height, weight, and head circumference were -1.24, -0.72, and -1.82 respectively. Over the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.2.150
更新日期:1995-02-01 00:00:00
abstract::Three paediatric pathologists, one perinatal paediatrician, one obstetrician, and one epidemiologist separately used information collected on 239 babies in an attempt to validate the Wigglesworth classification of perinatal deaths. This was first done using clinical data only, then using the combination of clinical an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.10_spec_no.1345
更新日期:1989-10-01 00:00:00
abstract::The development of a scale to measure perceived illness experience in young people with cancer is described. Areas of concern were first identified through semistructured interviews conducted with children and adolescents. As a result, 78 items were generated to cover the main areas identified (physical appearance, in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.4.302
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on the validated Gorelick Scales. DESIGN, SETTING AND PATIENTS:Prospective unblinded study from April 2016 to February 2017 in a paediatric emergency department. Patients aged 1 month to...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-318425
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Urolithiasis in renal transplant (RTx) recipients is a potential cause of allograft loss if obstruction is untreated. It is not clear if paediatric transplant recipients are following the global trend for increased prevalence of urolithiasis over time. DESIGN/SETTING/PATIENTS:A retrospective chart review was...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317203
更新日期:2020-01-01 00:00:00
abstract::A study was performed to compare adverse events and antibody response in term and preterm children vaccinated with diphtheria, tetanus, and pertussis vaccine at 2, 3, and 4 months of age. A total of 124 children were recruited and grouped according to gestational age: 37 weeks or more (n = 52), 34 to 36 weeks (n = 40)...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.3.230
更新日期:1995-03-01 00:00:00
abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.2.153
更新日期:1975-02-01 00:00:00
abstract:OBJECTIVE:Assays based on interferon gamma (IFNgamma) are an exciting new development for screening for latent tuberculosis infection (LTBI) in adults, but there are limited data on their effectiveness in children. Nevertheless new National Institute for Health and Clinical Excellence (NICE) guidelines recommend their ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.106617
更新日期:2008-03-01 00:00:00
abstract:AIMS:To document the patterns of presentation and outcome of severe anticholinesterase insecticide poisoning in children requiring intensive care. METHODS:Retrospective case note review of all 5541 children admitted to the paediatric intensive care unit (PICU) of a university hospital during the 10 years from January ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.5.352
更新日期:2002-05-01 00:00:00
abstract::Results of a questionnaire returned by 20 doctors giving information of 249 schools showed that many of the rooms made available to school health services are inadequate in terms of physical resources and privacy. A higher set of standards is recommended to enable schools and pupils to derive maximum benefit from comm...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.6.542
更新日期:1994-06-01 00:00:00