Abstract:
:Over a 25 year period, 31 asthmatic children received artificial ventilation for acute asthma at Alder Hey Children's Hospital on 48 occasions. Altogether 47 episodes occurred from 1971-89, with no decline in the number of episodes per year (mean 2.5) over this period. Eight children died during intermittent positive pressure ventilation (IPPV), and of the 23 survivors, three further children had subsequently died from asthma. Seventeen children were followed up for more than a year after IPPV. Sixteen still had symptoms of asthma and over half had symptoms every day. Ten cooperated with pulmonary function tests: mean forced expiratory volume in one second was 83% of predicted and geometric mean provocative histamine concentration (PC20) was 2.1 mg/ml. Since the follow up study a fourth patient had died from asthma. IPPV continues to be required for a small number of asthmatic children each year. The survivors remain a high risk group with significant continuing morbidity and mortality.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Seddon PC,Heaf DPdoi
10.1136/adc.65.12.1324subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1324-7; discussion 1327-8issue
12eissn
0003-9888issn
1468-2044journal_volume
65pub_type
杂志文章abstract:OBJECTIVE:To study the clinical characteristics and predictors of mortality from snake bite envenomation in children. DESIGN:Prospective observational study with a one-group cohort design. SETTING:Paediatric intensive care unit of a tertiary care hospital in South India. SUBJECTS:The study cohort consisted of 145 ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311142
更新日期:2017-05-01 00:00:00
abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.2.153
更新日期:1975-02-01 00:00:00
abstract::The term Ehlers-Danlos syndrome (EDS) encompasses a group of inherited connective tissue disorders. The manifestations of EDS can be seen in skin, joints, blood vessels and internal organs and vary from mild to severe and life threatening. Each subtype is a separate and different condition. The genetic basis of many s...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-304822
更新日期:2015-01-01 00:00:00
abstract::Clinical observations and findings on imaging are reported in six newborns with symmetrical thalamic lesions (STL). In three cases the diagnosis was confirmed by postmortem examination. Characteristic observations in this series and 17 previously reported cases include no evidence of perinatal asphyxia, high incidence...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1_spec_no.15
更新日期:1992-01-01 00:00:00
abstract::19 young children (less than 5 years old) have received 31 renal transplants from 4 live relatives and 27 cadaver donors. The 2-year allograft survival rate for the patients receiving their 1st allograft from the 4 live donors was 75 +/- 22% while for the patients receiving their 1st allograft from 15 cadaver donors w...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.7.532
更新日期:1980-07-01 00:00:00
abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.9.1091
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To undertake a systematic review and meta-analysis to establish the effectiveness of handwashing in reducing absence and/or the spread of respiratory tract (RT) and/or gastrointestinal (GI) infection among school-aged children and/or staff in educational settings. DESIGN:Randomised-controlled trials (RCTs). ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2015-308875
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Aerosol therapy in infants may be greatly compromised by face mask rejection due to squirming and crying. Lung aerosol deposition in crying infants may thereby be greatly reduced. Since 'suckling' on a pacifier calms infants, they should more readily accept a face mask that incorporates a pacifier. However...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/archdischild-2011-301236
更新日期:2012-06-01 00:00:00
abstract:AIM:Childhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses. METHODS:Children <16 years of age hospitalised in a French tertiary care...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2016-310594
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Congenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life. METHODS:Twen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308450
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To characterise fetal brain growth in children with specific language impairment (SLI). DESIGN:A nested case-control study. SETTING:Perth, Western Australia. PARTICIPANTS:Thirty children meeting criteria for SLI at age 10 years were individually matched with a typically developing comparison child on sex, ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.180331
更新日期:2012-01-01 00:00:00
abstract::The auditory function of 370 infants, drawn from both low and high risk groups, was tested before postnatal discharge using three tests: standard auditory brain stem responses (ABR), automated analysis of ABR, and automated analysis of evoked otoacoustic emissions (OAE). All infants failing any neonatal test had furth...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.10_spec_no.1124
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Asthma is among the most common chronic diseases in childhood and is steadily increasing in prevalence. Better characterisation of factors that determine the risk of hospitalisation for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology. Thi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.106278
更新日期:2007-04-01 00:00:00
abstract::Thirty jaundiced neonates with diarrhoea who were being treated with phototherapy and 30 matched control infants were studied to try and find out the cause of the diarrhoea. Faecal osmolality and electrolyte concentrations were measured, which gave clear evidence that the diarrhoea arose from intestinal secretion. Rec...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.8.1161
更新日期:1989-08-01 00:00:00
abstract::24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily blood pressure of healthy schoolchildren and on patients with hypertension. The subjects studied were 123 healthy schoolchildren with a mean (SD) age of 12.5 (1.6) years (range 9.5-14.5 years), 24 children with border...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.2.90
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Studies on adolescent drug use are scarce as most studies do not distinguish between children and adolescents. Therefore, we assessed overall drug use in adolescents. METHODS:A retrospective cohort study was conducted using pharmacy dispensing records from 62 community pharmacies in the Netherlands. Dispens...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-314692
更新日期:2019-08-01 00:00:00
abstract::1 case study and a clinical study with laboratory rats examined the question of breast milk jaundice. The case study confirmed clinical diagnosis of breast milk jaundice. The clinical study compared the effects of breast milk and 3alpha, 20beta-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat li...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.46.246.195
更新日期:1971-04-01 00:00:00
abstract::The aim of this study was to determine whether doctors recognise eating disorders in children, in particular anorexia nervosa. A group of paediatricians, general practitioners, and school medical officers was approached to participate in the study. Each was sent a questionnaire including two case vignettes of children...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1.103
更新日期:1992-01-01 00:00:00
abstract::Three cases of osteoid osteoma and one of benign osteoblastoma in children are described. The main complaint was severe pain which was worse at night; it was relieved by aspirin or other analgesics. The diagnosis was made on clinical and radiological grounds and was confirmed on histological examination of the central...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.6.459
更新日期:1979-06-01 00:00:00
abstract::A double blind crossover trial of 20 micrograms intranasal 1-deamino-8-d-arginine vasopressin (DDAVP) versus placebo was carried out in 17 children with intractable enuresis aged between 6 and 13 years who had failed to respond to drugs and an enuresis alarm. Fluid intake was not restricted. There was a significant re...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.61.11.1104
更新日期:1986-11-01 00:00:00
abstract::The long term results of treatment of inhalation of foreign bodies in a district children's hospital and in a tertiary referral centre were reviewed by clinical assessment, chest radiography, and standard four view 81mKr ventilation/99mTc macroaggregated albumin perfusion imaging (V/Q lung scan). The overall incidence...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.6.619
更新日期:1990-06-01 00:00:00
abstract:OBJECTIVE:Infections with multidrug-resistant organisms (MDROs) such as Gram-negative bacteria have high morbidity and mortality with limited treatment options. Colistin, an antibiotic active against MDRO, was rarely used due to frequent adverse effects, but its use has now been recommended among adults. In this study,...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-318067
更新日期:2020-09-01 00:00:00
abstract::Thirty seven healthy infants (18 born at full term and 19 preterm) were studied serially with cross sectional and Doppler echocardiography to compare their postnatal circulatory adaptation. Pulmonary artery pressure was assessed by its inverse relationship with the ratio of pulmonary artery time to peak velocity and r...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1_spec_no.24
更新日期:1990-01-01 00:00:00
abstract::Bilateral staghorn renal calculi in a 7-year-old girl with cystinuria were dissolved over a period of 6 months, using a high fluid intake, urinary alkalinisation, and D-penicillamine. Even in children with extensive cystine urolithiasis, medical management may avert the need for surgery. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.10.795
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE:To estimate the diagnostic accuracy of chest radiography in the detection of chest lymphadenopathy in children with clinically suspected pulmonary tuberculosis. METHODS: DESIGN:Prospective cross sectional study. SETTING:A short stay ward in a children's hospital in South Africa. PATIENTS:Consecutive child...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.062315
更新日期:2005-11-01 00:00:00
abstract::Diabetic control in 88 children attending three general paediatric clinics was compared prospectively over one year with that of 89 children attending a specialist paediatric diabetic clinic. Glycated haemoglobin (HbA1) concentration and days admitted were significantly lower in the group attending the specialist clin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.139
更新日期:1990-01-01 00:00:00
abstract::The USA has a long-standing paediatric influenza vaccination programme, including use of live attenuated influenza vaccine (LAIV). Following US evidence of apparent lack of vaccine effectiveness (VE) of LAIV in 2015/2016, particularly against A(H1N1)pdm09, the USA suspended the use of LAIV in the 2016/2017 season. The...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2016-312165
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To describe the clinical presentation and sequelae, including salt-wasting crises of newly-diagnosed congenital adrenal hyperplasia (CAH) in children aged over 1 year in a contemporary population without screening. To appraise the potential benefit of newborn screening for late-presenting CAH. DESIGN:Active...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-303070
更新日期:2014-01-01 00:00:00
abstract::The concentrations of immunoglobulins (Ig) G.A.M. and E were determined in paired umbilical cord and maternal sera in 50 twin pregnancies. Mean IgG levels were higher in cord than maternal sera and in most cases the cord IgG level related more closely to that of the other twin than to either maternal level or birthwei...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.5.354
更新日期:1976-05-01 00:00:00
abstract::It has been suggested that because of vascular interchange between the monozygous twins vascular disruptions from a deceased cotwin with disseminated intravascular coagulation causes embolisation in the surviving twin. This study reports six cases in which all the surviving monozygous twins had central nervous system ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.454
更新日期:1986-05-01 00:00:00