Development of secretory immunity in breast fed and bottle fed infants.

Abstract:

:Samples of saliva and nasal secretions were collected sequentially from 15 breast fed and 15 bottle fed infants on five occasions between 6 days and 9 months of age. Total immunoglobulin concentrations of G, M, and A classes, and class specific antibodies to tetanus toxoid and a pool of commensal strains of Escherichia coli were measured by solid phase radioimmunoassay and expressed per milligram of total protein. There were significant differences between feeding groups, which changed with age. Total IgM and IgA concentrations and IgA antibodies to E. coli were higher in the saliva and nasal secretions of breast fed infants at 6 days. There followed a rapid increase in IgM and IgA concentrations in secretions from all infants, and between 6 weeks and 9 months concentrations were higher in the saliva (but not in the nasal secretions) of the bottle fed group. There were no significant differences between the feeding groups for total IgG, specific G, M, and A antibodies to tetanus toxoid, and G and M antibodies to E. coli. These results suggest that breast feeding enhances secretory immunity in the early neonatal period only. By 6 weeks, local antigens are the main source of stimulation for production of immunoglobulin in the respiratory mucosa and thus may be obscuring any additional stimulation by growth factors in breast milk.

journal_name

Arch Dis Child

authors

Stephens S

doi

10.1136/adc.61.3.263

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

263-9

issue

3

eissn

0003-9888

issn

1468-2044

journal_volume

61

pub_type

杂志文章
  • Predictors of abdominal pain in schoolchildren: a 4-year population-based prospective study.

    abstract:BACKGROUND:Chronic abdominal pain (CAP) is common among schoolchildren, but risk factors for its onset are still largely unknown. AIMS:To determine the frequency of onset of CAP in schoolchildren and investigate risk factors for its development. METHODS:1411 schoolchildren aged 11-14 years were recruited from schools...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.115089

    authors: El-Metwally A,Halder S,Thompson D,Macfarlane GJ,Jones GT

    更新日期:2007-12-01 00:00:00

  • Treatment of hypogammaglobulinaemia with intravenous immunoglobulin, 1973-93.

    abstract:AIMS:To review the results of long term high dose intravenous immunoglobulin treatment. METHODS:162 treatment years in 18 patients with hypogammaglobulinaemia who received intravenous immunoglobulin treatment between 1973 and 1993 were reviewed. RESULTS:A mean dose of 0.42 g/kg immunoglobulin resulted in a mean troug...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.6.527

    authors: Skull S,Kemp A

    更新日期:1996-06-01 00:00:00

  • An overview of respiratory problems in children with Down's syndrome.

    abstract::Respiratory disease is a common cause of morbidity and mortality in children with Down's syndrome (DS). Causes range from those problems common to many children with DS, such as a narrow airway or impaired immunity, to rare structural lesions, such as tracheal bronchus. Additionally, other organ systems or extrinsic f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2013-304611

    authors: Watts R,Vyas H

    更新日期:2013-10-01 00:00:00

  • Imaging in urinary tract infection.

    abstract::The relationship of vesicoureteric reflex (VUR) and renal scarring was studied in 94 children (188 kidneys) with proved urinary tract infection in a district general hospital. There were 61 girls and 33 boys, with nine girls and 17 boys aged less than 1 year, 31 girls and nine boys aged between 1 and 5 years, the rema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.11.1282

    authors: Gleeson FV,Gordon I

    更新日期:1991-11-01 00:00:00

  • Assent for children's participation in research is incoherent and wrong.

    abstract::When children are considered for participation in research, British and international guidelines suggest that they should provide assent in addition to their parents' consent. However, examination of these guidelines shows there is confusion regarding the concept of assent. Furthermore, the need for assent may cause p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2011.211342

    authors: Baines P

    更新日期:2011-10-01 00:00:00

  • Near-miss SIDS due to Brugada syndrome.

    abstract::A 19 day old infant was successfully resuscitated from ventricular fibrillation. The 12 lead ECG was normal, with a normal QT interval, and remains so over three years follow up. DNA analysis revealed a missense mutation (R1193Q) in the SCN5A gene, previously linked with familial sudden unexpected nocturnal death synd...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.058115

    authors: Skinner JR,Chung SK,Montgomery D,McCulley CH,Crawford J,French J,Rees MI

    更新日期:2005-05-01 00:00:00

  • Use of DNA estimation for growth assessment in normal and hypoplastic fetal lungs.

    abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.8.601

    authors: Wigglesworth JS,Desai R

    更新日期:1981-08-01 00:00:00

  • A BPA survey of recently appointed consultants.

    abstract::A postal survey of recently appointed consultant paediatricians was undertaken to determine whether they perceived their training had adequately equipped them for their current job. The response rate was 69% (207/299). After excluding replies from consultants trained outside the UK the analysis was carried out on 167 ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.4.381

    authors: Lenton SW,Dison PJ,Haines LC

    更新日期:1994-10-01 00:00:00

  • Pregnanediols and breast milk jaundice.

    abstract::Samples of breast milk collected from mothers of infants with breast milk jaundice were analysed for 5 beta-pregnane-3 alpha, 20 beta-diol, and other pregnanediols using gas chromatography-high resolution mass spectrometry. None was detected in any of the specimens and therefore it is unlikely to be the inhibitory fac...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.6.474

    authors: Murphy JF,Hughes I,Verrier Jones ER,Gaskell S,Pike AW

    更新日期:1981-06-01 00:00:00

  • Neonatal renal candidal bezoar.

    abstract::Renal candidal bezoar is uncommonly encountered in neonatal intensive care. An affected neonate who improved only after surgical removal of obstructive fungus from the renal pelvis and local irrigation with amphotericin B is described. The need for early consideration of surgical intervention is stressed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.1_spec_no.63

    authors: Rehan VK,Davidson DC

    更新日期:1992-01-01 00:00:00

  • Serum cholecystokinin, basal acid secretion, and infantile pyloric stenosis.

    abstract::The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.10.773

    authors: Rogers IM,Drainer IK,Dougal AJ,Black J,Logan R

    更新日期:1979-10-01 00:00:00

  • Diagnosis of interstitial lung disease by a percutaneous lung biopsy sample.

    abstract::A percutaneous lung biopsy sample was used to diagnose interstitial lung disease in nine children aged less than 42 months. Fibrosing alveolitis was diagnosed in eight children and Pneumocystis carinii pneumonia in one child. Complications associated with the procedure were minimal and the results of the biopsy sample...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.2.143

    authors: Smyth RL,Carty H,Thomas H,van Velzen D,Heaf D

    更新日期:1994-02-01 00:00:00

  • Renal solute load in preterm infants.

    abstract::We performed metabolic balance studies in 77 preterm infants fed on human milk or adapted formulas, to determine the renal solute load and compared it with the potential renal solute load estimated by the composition of the diet or the urine according to Ziegler's, Bergman's, and Shaw's calculations. The renal solute ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.4_spec_no.357

    authors: De Curtis M,Senterre J,Rigo J

    更新日期:1990-04-01 00:00:00

  • Detection of antibodies to human parvovirus in erythema infectiosum (fifth disease).

    abstract::Two Japanese outbreaks of erythema infectiosum were investigated for evidence of human parvovirus infection by a solid phase antibody capture radioimmunoassay based on a monoclonal antibody to human parvovirus. Specific IgM and high concentrations of specific IgG were detected in 37 sera from 27 children with erythema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.11.1016

    authors: Okabe N,Koboyashi S,Tatsuzawa O,Mortimer PP

    更新日期:1984-11-01 00:00:00

  • Monitoring of cerebral function after severe asphyxia in infancy.

    abstract::Thirty nine infants with severe asphyxia (28 affected perinatally and 11 later) were studied by electrophysiological cerebral function monitoring (CFM) for periods varying from a half to 49 days. Nineteen infants died while still in intensive care and two died later from sequelae. Eighteen survived and were followed u...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.12.997

    authors: Bjerre I,Hellström-Westas L,Rosén I,Svenningsen N

    更新日期:1983-12-01 00:00:00

  • Venous thromboembolism in infancy and childhood.

    abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.2.153

    authors: Jones DR,Macintyre IM

    更新日期:1975-02-01 00:00:00

  • Successful implementation of spacer treatment guideline for acute asthma.

    abstract:AIMS:To develop and implement an evidence based guideline for the treatment of acute asthma using a metered dose inhaler and spacer combination. METHODS:Defined strategies were used for the development and implementation of a guideline, assessed by a prospective, descriptive, study using notes review, and patient, nur...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.2.142

    authors: Powell CV,Maskell GR,Marks MK,South M,Robertson CF

    更新日期:2001-02-01 00:00:00

  • Relation between insulin-like growth factor-I, body mass index, and clinical status in cystic fibrosis.

    abstract:OBJECTIVES:Despite improved nutrition and intensive treatment, subjects with cystic fibrosis have difficulty in maintaining anabolism during intercurrent infections, which can result in reduced body mass index and impaired skeletal growth. Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP3 are sensitiv...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.4.304

    authors: Taylor AM,Bush A,Thomson A,Oades PJ,Marchant JL,Bruce-Morgan C,Holly J,Ahmed L,Dunger DB

    更新日期:1997-04-01 00:00:00

  • Effects of overweight on lung function.

    abstract::Spirometric data from 1586 healthy children, who did not smoke, were analysed to examine the effects of overweight as measured by the body mass index (weight/height2) on lung function. Overweight (72 boys, 88 girls) was defined as on or above the 90th percentile weight for height. After having controlled for the confo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.5.512

    authors: Fung KP,Lau SP,Chow OK,Lee J,Wong TW

    更新日期:1990-05-01 00:00:00

  • Late clinical presentation of congenital adrenal hyperplasia in older children: findings from national paediatric surveillance.

    abstract:OBJECTIVES:To describe the clinical presentation and sequelae, including salt-wasting crises of newly-diagnosed congenital adrenal hyperplasia (CAH) in children aged over 1 year in a contemporary population without screening. To appraise the potential benefit of newborn screening for late-presenting CAH. DESIGN:Active...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303070

    authors: Knowles RL,Khalid JM,Oerton JM,Hindmarsh PC,Kelnar CJ,Dezateux C

    更新日期:2014-01-01 00:00:00

  • Early development of infants 1000 g or less at birth.

    abstract::In a 4-year period the neonatal survival rate for 26 infants weighing 501-750 g was 42% and for 81 infants weighing 751-1000 g it was 61%. All 59 surviving infants have been assessed at follow-up; 39 were at least 2 years old (corrected for prematurity) and data from the remaining 20 were derived from assessment at 1 ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.57.11.823

    authors: Orgill AA,Astbury J,Bajuk B,Yu VY

    更新日期:1982-11-01 00:00:00

  • HCG stimulation test in children with abnormal sexual development.

    abstract::Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.8.596

    authors: Grant DB,Laurance BM,Atherden SM,Ryness J

    更新日期:1976-08-01 00:00:00

  • Teratogenic effect of carbamazepine.

    abstract::A girl was born to a mother who had undergone treatment for epilepsy with carbamazepine during pregnancy. The infant had dysmorphic features and was physically and mentally retarded. We consider that the malformations were the result of the maternal treatment with carbamazepine. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.5.641

    authors: Vestermark V,Vestermark S

    更新日期:1991-05-01 00:00:00

  • Familial congenital heart block and hydrops fetalis.

    abstract::Two siblings were born with congenital heart block, and one suffered from severe hydrops fetalis, although maintaining a higher heart rate than the other. The association of hydrops fetalis with disorders of cardiac rhythm is unlikely to be simply a manifestation of congestive cardiac failure in the fetus. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.6.479

    authors: Cooke RW,Mettau JW,Van Cappelle AW,de Villeneuve VH

    更新日期:1980-06-01 00:00:00

  • The natural history and predictors of persistent problem behaviours in cystic fibrosis: a multicentre, prospective study.

    abstract:BACKGROUND:In cystic fibrosis (CF), problems with sleep, eating/mealtime behaviours, physiotherapy adherence and parental mental health issues are common, yet their natural history and the extent of service use to address them are unknown. OBJECTIVE:Follow up the 2007 cohort to determine: (1) prevalence of child sleep...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2011-301527

    authors: Sheehan J,Massie J,Hay M,Jaffe A,Glazner J,Armstrong D,Hiscock H

    更新日期:2012-07-01 00:00:00

  • Distinguishing infant prolonged crying from sleep-waking problems.

    abstract:OBJECTIVE:Infants who cry a lot, or are unsettled in the night, are common sources of concern for parents and costly problems for health services. The two types of problems have been linked together and attributed to a general disturbance of infant regulation. Yet the infant behaviours involved present differently, at ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.200204

    authors: St James-Roberts I,Peachey E

    更新日期:2011-04-01 00:00:00

  • Evaluation of delayed puberty: what diagnostic tests should be performed in the seemingly otherwise well adolescent?

    abstract::Delayed puberty (DP) is defined as the lack of pubertal development by an age that is 2-2.5 SDs beyond the population mean. Although it generally represents a normal variant in pubertal timing, concern that DP could be the initial presentation of a serious underlying disorder has led to a diagnostic approach that is v...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2015-310375

    authors: Abitbol L,Zborovski S,Palmert MR

    更新日期:2016-08-01 00:00:00

  • Effect of obesity on endogenous secretion of growth hormone in Turner's syndrome.

    abstract::Nocturnal growth hormone secretion over a 12 hour period was assessed at 20 minute intervals in 25 prepubertal subjects with Turner's syndrome and 11 normal prepubertal girls of short stature to try and elucidate the relationship between body weight and endogenous secretion of growth hormone in Turner's syndrome. Ther...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.10.1184

    authors: Lu PW,Cowell CT,Jimenez M,Simpson JM,Silink M

    更新日期:1991-10-01 00:00:00

  • Referrals to a regional neonatal intensive care unit.

    abstract::Over a three year period 444 requests for the neonatal transfer of babies with acute medical problems were received at this regional neonatal medical unit. Despite an increase in available resources in the North Western Health Region the provision of intensive care remained inadequate with 38% of requests declined, an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.4.403

    authors: Roper HP,Chiswick ML,Sims DG

    更新日期:1988-04-01 00:00:00

  • Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H(+)-K(+)-ATPase deficiency.

    abstract::We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gast...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.6.504

    authors: Simpson AM,Schwartz GJ

    更新日期:2001-06-01 00:00:00