Prevalence of nasopharyngeal carriage of pneumococcus in preschool children attending day care in London.

Abstract:

OBJECTIVE:To estimate the prevalence of nasopharyngeal (NP) carriage of pneumococcus (Streptococcus pneumoniae) and describe the antibiotic resistance patterns and serotypes in young children attending group day care in London. DESIGN AND SUBJECTS:Cross-sectional survey of attendees at a sample of registered child day care centres (CDCCs) in a London borough. SETTING:Urban setting with a socially and culturally diverse population. METHODS AND OUTCOMES:19 CDCCs (13% of total) participated between March and November 2003. A single NP swab was required from each child, and parents completed a questionnaire about their child's health and attendance at day care. WHO methodology for pneumococcal carriage studies was followed. RESULTS:30% of parents consented. 234 swabs were collected from children aged 6 months to 5 years. 53% were boys and 81% were white. 120 children (51%, 95% CI 45% to 58%) carried pneumococci in their nasopharynx. None of the isolates were resistant to penicillin (upper CL 3%). 21 isolates were resistant to erythromycin (17.5%, 95% CI 11% to 25.5%). 68 isolates (57%) were serotypes included in the 7-valent conjugate vaccine. Non-white children had a lower prevalence of carriage (27% vs 58%). CONCLUSION:The prevalence of pneumococcal NP carriage was high. The penicillin resistance rate is lower than in many other countries and may reflect a decrease in community antibiotic prescribing in the UK. Monitoring circulating serotypes is important in the context of recent changes to the vaccination policy. Further study is required to explore the association with ethnicity and risk factors for antibiotic resistance.

journal_name

Arch Dis Child

authors

Roche A,Heath PT,Sharland M,Strachan D,Breathnach A,Haigh J,Young Y

doi

10.1136/adc.2007.126359

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1073-6

issue

12

eissn

0003-9888

issn

1468-2044

pii

adc.2007.126359

journal_volume

92

pub_type

杂志文章
  • DDAVP and urine osmolality in refractory enuresis.

    abstract::A double blind crossover trial of 20 micrograms intranasal 1-deamino-8-d-arginine vasopressin (DDAVP) versus placebo was carried out in 17 children with intractable enuresis aged between 6 and 13 years who had failed to respond to drugs and an enuresis alarm. Fluid intake was not restricted. There was a significant re...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.61.11.1104

    authors: Dimson SB

    更新日期:1986-11-01 00:00:00

  • Educational attainment in childhood cancer survivors: a meta-analysis.

    abstract:OBJECTIVE:To assess differences across educational outcomes in survivors of childhood cancer (CCS) compared with peers. DESIGN:Systematic review and meta-analysis of observational studies. DATA SOURCES AND STUDY SELECTION:Medline, EMBASE, ERIC, CINAHL and PsycInfo from inception to 1st August 2018. Any peer reviewed,...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2019-317594

    authors: Saatci D,Thomas A,Botting B,Sutcliffe AG

    更新日期:2020-04-01 00:00:00

  • Maternal insecurity and failure to thrive in Asian children.

    abstract::Four Asian babies were investigated because they failed to thrive. In all four cases the failure to thrive was a result of the mother's social isolation and inability to communicate, and to the father's refusal to accept that there was a problem in the family. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.3.369

    authors: Fenton TR,Bhat R,Davies A,West R

    更新日期:1989-03-01 00:00:00

  • Cord blood IgE and month of birth.

    abstract::If cord blood IgE is used to detect those predisposed to become allergic it is important to define appropriately the normal values for this measurement. A commonly cited cut off point is 1.0 IU/ml. We analysed 5353 cord blood samples for IgE by means of an enzyme linked immunosorbent assay. Descriptive statistics of t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.5.478

    authors: Kimpen J,Callaert H,Embrechts P,Bosmans E

    更新日期:1987-05-01 00:00:00

  • Bile acid excretion after pull-through operation for Hirschsprung's disease.

    abstract::Four children with chronic diarrhoea and perianal excoriation after a pull-through operation for Hirschsprung's disease have been shown to have increased but not markedly raised levels of faecal bile acids. Bile acid analysis of the 'bile-rich' duodenal fluid obtained after pancreozymin stimulation in 3 of the patient...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.3.243

    authors: Gaze H,Murphy GM,Nelson R,Corkery JJ,Anderson CM

    更新日期:1975-03-01 00:00:00

  • Discontinuation of continuous positive airways pressure in infants with respiratory distress syndrome.

    abstract::Unexpected stability of arterial oxygen and carbon dioxide tensions occurred in infants recovering from respiratory distress syndrome (RDS) on the abrupt withdrawal of CPAP at 6 cmH2O pressure. 30 preterm infants (birthweights 880--3200 g gestational ages 29--38 weeks) were treated at a mean age of 10 hours and for a ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.9.722

    authors: Hegyi T,Hiatt IM

    更新日期:1979-09-01 00:00:00

  • Delphi method to identify expert opinion to support children's cancer referral guidelines.

    abstract:BACKGROUND:The National Institute for Health and Care Excellence (NICE) guidance for referral of children with suspected cancer was first published in 2005 and updated in 2015. The updated version relied on sparse primary care evidence and published without input from key stakeholders, for example, acute general paedia...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317235

    authors: Murray MJ,Ruffle A,Lowis S,Howell L,Shanmugavadivel D,Dommett R,Gamble A,Shenton G,Nicholson J

    更新日期:2020-03-01 00:00:00

  • Factors influencing breast feeding.

    abstract::A survey is reported of infant feeding practice at the time of discharge from a single maternity ward. It is shown that a change in the attitude of nursing staff increased the number of mothers breast feeding their infants and eliminated the practice of giving the infants formula feed complements. This change in attit...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.3.165

    authors: McKean KS,Baum JD,Sloper K

    更新日期:1975-03-01 00:00:00

  • Hydrogen breath test in schoolchildren.

    abstract::The frequency of negative hydrogen breath tests due to colonic bacterial flora which are unable to produce hydrogen was determined after oral lactulose challenge in 98 healthy Dutch schoolchildren. There was a negative result in 9.2%. The probability of a false normal lactose breath test (1:77) was calculated from the...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.4.333

    authors: Douwes AC,Schaap C,van der Klei-van Moorsel JM

    更新日期:1985-04-01 00:00:00

  • Familial partial trisomy of the long arm of chromosome 3 (3q).

    abstract::A case of partial trisomy of the long arm of chromosome 3 (3q21 leads to qter) is described. The clinical findings are compared with those in 5 previously reported cases. There is hirsutism and characteristic facial dysmorphism, the common features of which are a square-shaped face, prominent nasal bridge, everted nos...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.2.135

    authors: Fear C,Briggs A

    更新日期:1979-02-01 00:00:00

  • Diarrhoea in jaundiced neonates treated with phototherapy: role of intestinal secretion.

    abstract::Thirty jaundiced neonates with diarrhoea who were being treated with phototherapy and 30 matched control infants were studied to try and find out the cause of the diarrhoea. Faecal osmolality and electrolyte concentrations were measured, which gave clear evidence that the diarrhoea arose from intestinal secretion. Rec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.8.1161

    authors: De Curtis M,Guandalini S,Fasano A,Saitta F,Ciccimarra F

    更新日期:1989-08-01 00:00:00

  • Attention deficit hyperactivity disorder: legal and ethical aspects.

    abstract::Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.064576

    authors: Foreman DM

    更新日期:2006-02-01 00:00:00

  • A new paradigm for developing drugs in children: atomoxetine as a model.

    abstract::When prescribing drugs for children, it is fundamental to acknowledge that they are distinct from adults with a different physiology and metabolism. They are also still maturing. The development of drugs with a primarily paediatric indication thus requires the trialling of these drugs in a paediatric population to ass...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.059378

    authors: Prasad S

    更新日期:2005-02-01 00:00:00

  • Inappropriate oral formulations and information in paediatric trials.

    abstract::Previously, quality of formulations information provided for oral medications used in paediatric clinical trials published in 10 highly cited journals between 2002 and 2004 raised concerns. This short report explores if there was any subsequent improvement on how the formulations used in trials involving children <12 ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.175661

    authors: Pandit S,Shah U,Kirby DJ,Nunn T,Tuleu C

    更新日期:2010-09-01 00:00:00

  • Adenovirus type 8 conjunctivitis outbreak in a neonatal intensive care unit.

    abstract::An outbreak of adenovirus type 8 conjunctivitis occurred in seven premature infants who had undergone ophthalmological examination four to seven days previously. Three of the affected infants, treated with steroids because of bronchopulmonary dysplasia, showed systemic manifestations and deterioration of their respira...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.5_spec_no.610

    authors: Birenbaum E,Linder N,Varsano N,Azar R,Kuint J,Spierer A,Reichman B

    更新日期:1993-05-01 00:00:00

  • Mannosidosis. Clinical and biochemical study.

    abstract::The clinical, radiological, and biochemical features of 2 male children with mannosidosis are described. Superficially they appeared to suffer from Hurler's syndrome, but the facies, eye signs, radiological and cytological features were atypical. Excess urinary oligosaccharides were found by thin-layer chromatography....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.12.937

    authors: Milla PJ,Black IE,Patrick AD,Hugh-Jones K,Oberholzer V

    更新日期:1977-12-01 00:00:00

  • Risk factors predisposing to pedestrian road traffic injury in children living in Lima, Peru: a case-control study.

    abstract:OBJECTIVE:To describe the epidemiology of pedestrian road traffic injury in Lima and to identify associated child-level, family-level, and school travel-related variables. DESIGN:Case-control study. SETTING:The Instituto Nacional de Salud del Niño, the largest paediatric hospital in the city. PARTICIPANTS:Cases were...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2011-300997

    authors: Pernica JM,LeBlanc JC,Soto-Castellares G,Donroe J,Carhuancho-Meza BA,Rainham DG,Gilman RH

    更新日期:2012-08-01 00:00:00

  • Clostridial toxins in neonatal necrotising enterocolitis.

    abstract::Clostridium difficile cytopathic toxin was found in the faeces or gut content of five of 39 neonates with necrotising enterocolitis (NEC). Toxin concentrations were uniformly low and did not differ from those found in healthy neonates. C difficile is unlikely to be involved in the pathogenesis of NEC. Stools from 33 b...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.3.270

    authors: Thomas DF,Fernie DS,Bayston R,Spitz L

    更新日期:1984-03-01 00:00:00

  • Airway function in infants with vascular rings: preoperative and postoperative assessment.

    abstract::Aortic arch anomalies in infancy often cause intrathoracic airway obstruction. Airway function was assessed as part of the diagnostic evaluation in six symptomatic infants both by plethysmography and using a chest compression technique to obtain partial flow-volume loops. Two infants had normal intrathoracic airway fu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.2.171

    authors: Thomson AH,Beardsmore CS,Firmin R,Leanage R,Simpson H

    更新日期:1990-02-01 00:00:00

  • Intestinal disease in cystic fibrosis.

    abstract::Three children with cystic fibrosis developed steatorrhoea unresponsive to changes in pancreatic supplements. The final diagnoses were chronic giardiasis, stagnant loop syndrome, and Crohn's disease. Refractory intestinal symptoms in cystic fibrosis merit further investigation. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.12.1496

    authors: Baxter PS,Dickson JA,Variend S,Taylor CJ

    更新日期:1988-12-01 00:00:00

  • The effect of asthma and its treatment on growth.

    abstract::Asthma has little, if any, significant effect on attained adult height. Untreated asthma results in a delay of puberty by approximately 1.3 years, and pubertal delay is likely to explain the majority of apparent growth failure in asthmatics. All currently available inhaled corticosteroids (ICS) result in growth suppre...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2003.014365

    authors: Doull IJ

    更新日期:2004-01-01 00:00:00

  • Metabolic and hormonal responses of low birthweight infants to intravenously infused calories not exceeding the maintenance energy expenditure.

    abstract::Eithe low birthweight infants were studied for their metabolic and hormonal responses to intravenous alimentation when the caloric input was varied. The study was made during three consecutive 12-hour periods, when solutions of glucose, glucose and amino-acids, and glucose and amino-acid and lipids were successively i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.7.499

    authors: Rubecz I,Mestyán J,Varga P,Soltész G

    更新日期:1979-07-01 00:00:00

  • Human metapneumovirus infections in hospitalised infants in Spain.

    abstract:BACKGROUND:Human metapneumovirus (hMPV) causes lower respiratory tract infections, particularly in young children and the elderly. METHODS:A prospective study was conducted on the clinical characteristics of infants <2 years of age admitted to hospital for respiratory infection and the characteristics of hMPV infectio...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.082388

    authors: García-García ML,Calvo C,Martín F,Pérez-Breña P,Acosta B,Casas I

    更新日期:2006-04-01 00:00:00

  • Generalised lymphangiomatosis with chylothorax.

    abstract::A 9 month old boy presented with acute respiratory distress and was found to have a left pleural effusion. The chylous nature of the effusion, multiple bony lytic lesions, and splenic cysts lead to the diagnosis of congenital lymphangiomatosis with chylothorax. Surgical intervention including pleurectomy was required ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.7.1058

    authors: Dunkelman H,Sharief N,Berman L,Ninan T

    更新日期:1989-07-01 00:00:00

  • Patterns of long-term ADHD medication use in Australian children.

    abstract:OBJECTIVE:Adherence to attention-deficit/hyperactivity disorder (ADHD) medication treatment is often suboptimal. This can compromise patient outcomes. We aimed to describe the patterns of ADHD medication use in Australian children, and characteristics associated with patterns of use. DESIGN:Dispensing data were analys...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317997

    authors: Efron D,Mulraney M,Sciberras E,Hiscock H,Hearps S,Coghill D

    更新日期:2020-06-01 00:00:00

  • Use of external expiratory resistance in intubated neonates to increase lung volume.

    abstract::Ten intubated neonates (weights 0.90 to 2.58 kg) recovering from respiratory disease had lung mechanics, respiratory patterns, and functional residual capacity measured at 0 cmH2O continuous positive airways pressure and then after application of serially increasing levels of external expiratory resistance. At an exte...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.11.869

    authors: Moomjian AS,Schwartz JG,Shutack JG,Rooklin AR,Shaffer TH,Fox WW

    更新日期:1981-11-01 00:00:00

  • A decade of growth hormone treatment in girls with Turner syndrome in the UK. UK KIGS Executive Group.

    abstract::Fifteen per cent of children treated with growth hormone (GH) are receiving treatment for Turner syndrome, but few results are available on final height in the UK. In this study, data were obtained from the UK KIGS database for 485 girls with Turner syndrome who were treated from 1986, allowing an audit of practice an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.3.221

    authors: Betts PR,Butler GE,Donaldson MD,Dunger DB,Johnston DI,Kelnar CJ,Kirk J,Price DA,Wilton P

    更新日期:1999-03-01 00:00:00

  • Coeliac disease in identical twins.

    abstract::Coeliac disease occurred at the same age in MZ twins. The diagnosis was confirmed by histology of the small intestine, rapid response to a gluten-free diet, and relapse after reintroduction of gluten. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.5.395

    authors: Penna FJ,Mota JA,Roquete ML,de Carvalho AS,de Oliveira Lemos AT,Barbosa AJ,Leao E,Ferreira RA,de Paula Castro L

    更新日期:1979-05-01 00:00:00

  • Hepatopathy of Mauriac syndrome: a retrospective review from a tertiary liver centre.

    abstract:BACKGROUND:Mauriac syndrome is characterised by growth failure, cushingoid appearance and hepatomegaly which occurs in patients with insulin dependent diabetes and was first described shortly after the introduction of insulin as a treatment for the condition. OBJECTIVE:To describe the clinical features, histological f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-304426

    authors: Fitzpatrick E,Cotoi C,Quaglia A,Sakellariou S,Ford-Adams ME,Hadzic N

    更新日期:2014-04-01 00:00:00

  • Specialist paediatric palliative care services: what are the benefits?

    abstract:BACKGROUND:The number of children and young people (CYP) living with life-limiting and life-threatening conditions is rising. Paediatric palliative care is a relatively new aspect of healthcare, the delivery of which is variable, with a wide range of healthcare and voluntary sector providers involved. Policy recommenda...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2016-312026

    authors: Mitchell S,Morris A,Bennett K,Sajid L,Dale J

    更新日期:2017-10-01 00:00:00