The effect of asthma and its treatment on growth.

Abstract:

:Asthma has little, if any, significant effect on attained adult height. Untreated asthma results in a delay of puberty by approximately 1.3 years, and pubertal delay is likely to explain the majority of apparent growth failure in asthmatics. All currently available inhaled corticosteroids (ICS) result in growth suppression at conventional doses (400 microg/day of beclomethasone dipropionate equivalent), but the growth suppressive effects are relatively short lived, after which growth reverts to pretreatment levels. Younger, prepubertal children, appear more sensitive to the growth suppressive effects of ICS. Asthmatic children receiving conventional doses of ICS (400 microg/day of BDP equivalent) will attain an adult height indistinguishable from their predicted adult height (based on their mid parental height), and no different from non-asthmatics. Adult height could possibly be decreased in severe asthmatics, but this is unlikely to be greater than a 1.2 cm decrement. Recent longitudinal studies offer reassurance that at conventional doses ICS do not have significant long term effects on growth, and that their benefits consistently outweigh their side effects.

journal_name

Arch Dis Child

authors

Doull IJ

doi

10.1136/adc.2003.014365

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

60-3

issue

1

eissn

0003-9888

issn

1468-2044

journal_volume

89

pub_type

杂志文章,评审
  • Specific malabsorption of vitamin B12 in Down's syndrome.

    abstract::A 3 year old girl with Down's syndrome became lethargic and withdrawn, and investigations showed a specific malabsorption of vitamin B12 without proteinuria. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.5.514

    authors: Cartlidge PH,Curnock DA

    更新日期:1986-05-01 00:00:00

  • Aneurysms of the vein of Galen.

    abstract::Six neonates with aneurysms of the vein of Galen are described: five were associated with an intracerebral arteriovenous fistula and presented with heart failure in the neonatal period; one had hydrocephalus at birth. Two infants died from intractable cardiac failure within 48 hours of age and two from progressive hyd...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.11.1612

    authors: O'Donnabhain D,Duff DF

    更新日期:1989-11-01 00:00:00

  • Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.

    abstract:OBJECTIVE:Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce. METHODS:The effect of two different SNP (INSIG2: rs7566605, FTO: rs9939609) was analysed on the ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.147652

    authors: Reinehr T,Hinney A,Toschke AM,Hebebrand J

    更新日期:2009-12-01 00:00:00

  • A non-electrostatic spacer for aerosol delivery.

    abstract::A pear shaped non-electrostatic spacer, composed of steel with a volume of 250 ml and equipped with a facemask containing integrated inlet and outlet valves for inspiration and expiration, was compared with three plastic spacers. The plastic spacers were primed with repeated puffs from a budesonide pressurised metered...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.73.3.226

    authors: Bisgaard H,Anhøj J,Klug B,Berg E

    更新日期:1995-09-01 00:00:00

  • Hospitalisation for gastroenteritis in Western Australia.

    abstract:AIMS:To document gastroenteritis hospitalisations of the 1995-96 cohort of infants born in Western Australia to mid-2002, and to assess factors associated with their hospitalisations and readmissions. METHODS:Retrospective analysis of the State's hospitalisation data, Midwives' Notification of Births data, the Austral...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.037531

    authors: Gracey M,Lee AH,Yau KK

    更新日期:2004-08-01 00:00:00

  • Disproportionate head growth retardation in cystic fibrosis.

    abstract::Monthly increments of length, weight gain, and head circumference were recorded from birth to 4 years of age in 52 children with cystic fibrosis. At birth the children showed stunting. Standard deviation (SD) scores at birth for height, weight, and head circumference were -1.24, -0.72, and -1.82 respectively. Over the...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.2.150

    authors: Ghosal S,Taylor CJ,Pickering M,McGaw J,Beckles-Willson N,Wales JK

    更新日期:1995-02-01 00:00:00

  • Echocardiographic assessment of cardiac function in shocked very low birthweight infants.

    abstract::The contribution of abnormal cardiac function to hypotension and metabolic acidosis, which affect approximately 40% of ventilated very low birthweight infants in the first 24 hours after birth was assessed using M mode, two dimensional, and Doppler echocardiography in 75 very low birthweight infants during the first f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1_spec_no.17

    authors: Gill AB,Weindling AM

    更新日期:1993-01-01 00:00:00

  • Impact of functional severity on self concept in young people with spina bifida.

    abstract::This study examines the relationship between medical and functional severity of disability and levels of self esteem and self concept in 79 young people with spina bifida. Greater feelings of global self worth and of self esteem in physical appearance were associated with greater severity of disability. This was only ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.1.48

    authors: Minchom PE,Ellis NC,Appleton PL,Lawson V,Böll V,Jones P,Elliott CE

    更新日期:1995-07-01 00:00:00

  • Estimation of gestational age at birth. Comparison of two methods.

    abstract::Seventy-three low birthweight babies were independently assessed for gestational age using the scoring system of Dubowitz et al. (1970) and 5 neurological reflexes described by Robinson (1966). The results obtained by the 5 reflexes were compared with those obtained by the scoring system and were found to be accurate ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.6.509

    authors: Serfontein GL,Jaroszewicz AM

    更新日期:1978-06-01 00:00:00

  • Henoch-Schönlein syndrome and selective IgA deficiency.

    abstract::A 9 year old girl presented with clinical manifestations of Henoch-Schönlein syndrome and macroscopic haematuria. Laboratory investigations showed selective IgA deficiency and renal biopsy showed mesangial proliferative glomerulonephritis with diffuse granular deposits of C3 on immunofluorescence. IgA deposits were ab...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.2.160

    authors: Martini A,Ravelli A,Notarangelo LD,Burgio VL,Plebani A

    更新日期:1985-02-01 00:00:00

  • Beclomethasone dipropionate aerosol in treatment of hay fever in children.

    abstract::Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.50.11.875

    authors: Prahl P,Wilken-Jensen K,Mygind N

    更新日期:1975-11-01 00:00:00

  • Elemental diet for refractory atopic eczema.

    abstract::A total of 37 children with refractory wide-spread atopic eczema were treated with an antigen avoidance regimen comprising hospitalisation, exclusive feeding with an elemental formula for a median duration of 30 days, and measures to reduce exposure to pet and dust mite antigens at home. After the initial period of fo...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.66.1.93

    authors: Devlin J,David TJ,Stanton RH

    更新日期:1991-01-01 00:00:00

  • Children with life-limiting conditions in paediatric intensive care units: a national cohort, data linkage study.

    abstract:OBJECTIVE:To determine how many children are admitted to paediatric intensive care unit (PICU) with life-limiting conditions (LLCs) and their outcomes. DESIGN:National cohort, data-linkage study. SETTING:PICUs in England. PATIENTS:Children admitted to a UK PICU (1 January 2004 and 31 March 2015) were identified in t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-312638

    authors: Fraser LK,Parslow R

    更新日期:2018-06-01 00:00:00

  • Thermometers and rectal perforations in the neonate.

    abstract::Three neonates with rectal perforations probably caused by the use of the rectal thermometer, are reported. The dangers of this condition and the difficulty of diagnosis even at laporatomy are emphasised. It is suggested that since the axillary temperature in the neonate is an adequate reflection of the core temperatu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.10.824

    authors: Frank JD,Brown S

    更新日期:1978-10-01 00:00:00

  • Specialist paediatric palliative care services: what are the benefits?

    abstract:BACKGROUND:The number of children and young people (CYP) living with life-limiting and life-threatening conditions is rising. Paediatric palliative care is a relatively new aspect of healthcare, the delivery of which is variable, with a wide range of healthcare and voluntary sector providers involved. Policy recommenda...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2016-312026

    authors: Mitchell S,Morris A,Bennett K,Sajid L,Dale J

    更新日期:2017-10-01 00:00:00

  • Reflection: moving from a mandatory ritual to meaningful professional development.

    abstract::Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2013-303948

    authors: Murdoch-Eaton D,Sandars J

    更新日期:2014-03-01 00:00:00

  • Small bowel biopsy.

    abstract::We describe our technique of small bowel biopsy, which has been used on 190 occasions over a four year period. In 77%, the examination was completed within 10 minutes, and fluoroscopy times were less than 10 seconds in 75% of the cases. The technique is easily taught, and it has made the examination a minor procedure....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.11.1082

    authors: Collins AL,Brookfield DS,Hyde I,Rolles CJ

    更新日期:1985-11-01 00:00:00

  • How accurate is the diagnosis of exercise induced asthma among Vancouver schoolchildren?

    abstract:BACKGROUND:Limited access to exercise testing facilities means that the diagnosis of exercise induced asthma (EIA) is mainly based on self-reported respiratory symptoms. This is open to error since the correlation between exercise related symptoms and subsequent exercise testing has been shown to be poor. AIM:To study...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.063974

    authors: Seear M,Wensley D,West N

    更新日期:2005-09-01 00:00:00

  • Neonatal renal candidal bezoar.

    abstract::Renal candidal bezoar is uncommonly encountered in neonatal intensive care. An affected neonate who improved only after surgical removal of obstructive fungus from the renal pelvis and local irrigation with amphotericin B is described. The need for early consideration of surgical intervention is stressed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.1_spec_no.63

    authors: Rehan VK,Davidson DC

    更新日期:1992-01-01 00:00:00

  • Impact of oral corticosteroids on respiratory outcomes in acute preschool wheeze: a randomised clinical trial.

    abstract:OBJECTIVE:To determine if administration of oral prednisolone to preschool children with acute wheeze alters respiratory outcomes. DESIGN:Double-blind, randomised, placebo-controlled equivalence trial. SETTING:Three hospitals in New Zealand. PATIENTS:477 children aged 24-59 months with acute wheeze associated with r...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2020-318971

    authors: Wallace A,Sinclair O,Shepherd M,Neutze J,Trenholme A,Tan E,Brabyn C,Bonisch M,Grey N,Johnson DW,McNamara D,Thompson JMD,Asher I,Dalziel SR

    更新日期:2020-10-16 00:00:00

  • Effect of taurine supplementation on fat and energy absorption in cystic fibrosis.

    abstract::In 10 children with cystic fibrosis and persisting steatorrhoea, supplementation with taurine (30-40 mg/kg/day) was given for two months as an adjunct to the usual pancreatic enzyme treatment. A three day fat and energy balance was performed in patients with cystic fibrosis, before and after the supplementation, and i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.9.1082

    authors: De Curtis M,Santamaria F,Ercolini P,Vittoria L,De Ritis G,Garofalo V,Ciccimarra F

    更新日期:1992-09-01 00:00:00

  • Phototherapy for neonatal hyperbilirubinaemia: the importance of dose.

    abstract::The management of neonatal jaundice can be made much easier using simple methods that increase the radiant energy in the range 420 to 480 nm. Two groups of infants being treated for physiological jaundice during a period of 6 months were compared. The first group received treatment from two unmodified phototherapy uni...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.6.406

    authors: Modi N,Keay AJ

    更新日期:1983-06-01 00:00:00

  • Cellobiose: mannitol differential permeability in small bowel disease.

    abstract::Cellobiose and mannitol absorption were studied in patients with suspected abnormal function of the small bowel mucosa. The urinary cellobiose:mannitol ratio was increased in subtotal villous atrophy, iron deficiency anaemia, and small intestinal Crohn's disease. The test seems a sensitive indicator of the integrity o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.6.853

    authors: Hodges S,Ashmore SP,Patel HR,Tanner MS

    更新日期:1989-06-01 00:00:00

  • Clinical monitoring of steatorrhoea in cystic fibrosis.

    abstract::In 100 patients with cystic fibrosis the severity of steatorrhoea was assessed by three separate methods. Using chemical faecal fat assay as the gold standard, two other rapid and inexpensive methods were compared with it. The steatocrit method proved unreliable in our hands and gave little indication of the presence ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.1.99

    authors: Walters MP,Kelleher J,Gilbert J,Littlewood JM

    更新日期:1990-01-01 00:00:00

  • Overtreatment in threshold and developed countries.

    abstract::In acute paediatrics, overtreatment and overdiagnosis is encountered in threshold and developed countries. The reason for overtreatment may be similar in the two settings, namely the mere availability of invasive procedures, which may lead to their inappropriate use. Physiological healing processes should be integrate...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2007.124479

    authors: Frey B

    更新日期:2008-03-01 00:00:00

  • Behaviour and development in 24-month-old moderately preterm toddlers.

    abstract:OBJECTIVE:Moderately preterm children (gestational age 32-36+6 weeks) are at risk of cognitive and behaviour problems at school age. The aim of this study was to investigate if these problems are already present at the age of 2 years. STUDY DESIGN:Developmental outcome was assessed at 24-months (corrected age) with th...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2014-307016

    authors: de Jong M,Verhoeven M,Lasham CA,Meijssen CB,van Baar AL

    更新日期:2015-06-01 00:00:00

  • Rapid diagnosis of glucocorticoid suppressible hyperaldosteronism in infants and adolescents.

    abstract::Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and ch...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.1.40

    authors: Jamieson A,Inglis GC,Campbell M,Fraser R,Connell JM

    更新日期:1994-07-01 00:00:00

  • Increased prescribing trends of paediatric psychotropic medications.

    abstract::Psychotropic medication use by children in the USA has increased. We used the IMS MIDAS Prescribing Insights to examine prescribing trends in nine countries between the years 2000 and 2002. Trends in seven countries rose significantly from year 2000 to 2002; the UK had the highest increase (68%). ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2004.050468

    authors: Wong IC,Murray ML,Camilleri-Novak D,Stephens P

    更新日期:2004-12-01 00:00:00

  • Drooling Reduction Intervention randomised trial (DRI): comparing the efficacy and acceptability of hyoscine patches and glycopyrronium liquid on drooling in children with neurodisability.

    abstract:OBJECTIVE:Investigate whether hyoscine patch or glycopyrronium liquid is more effective and acceptable to treat drooling in children with neurodisability. DESIGN:Multicentre, single-blind, randomised controlled trial. SETTING:Recruitment through neurodisability teams; treatment by parents. PARTICIPANTS:Ninety childr...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/archdischild-2017-313763

    authors: Parr JR,Todhunter E,Pennington L,Stocken D,Cadwgan J,O'Hare AE,Tuffrey C,Williams J,Cole M,Colver AF

    更新日期:2018-04-01 00:00:00

  • Intestinal lymphangiectasia. Long-term results with MCT diet.

    abstract::The clinical course of 6 children with primary intestinal lymphangiectuasia who have been treated with low fat medium chain triglyceride-supplemented diets for between 3 and 8 years (4 for longer than 5 years) is described. Though laboratory findings indicate continuing chyle leak, evidence for long-term benefit from ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.269

    authors: Tift WL,Lloyd JK

    更新日期:1975-04-01 00:00:00