Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT.

Abstract:

OBJECTIVES:Data suggest a potential role for vitamin D in autism spectrum disorder (ASD). We wanted to assess the effect of vitamin D3 supplementation compared with placebo in children with ASD. DESIGN:This was a double-blind, randomised, placebo-controlled trial. SETTING:A paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). PATIENTS:42 children with ASD. INTERVENTIONS:2000 IU vitamin D3 supplementation or placebo daily for 20 weeks. MAIN OUTCOME MEASURES:Assessments were completed at baseline and after 20 weeks of supplementation. The primary outcome was the stereotypic behaviour subscale from the Aberrant Behaviour Checklist (ABC). Secondary exploratory outcomes included additional subscales from the ABC, the Social Responsiveness Scale and rating on the Developmental Disabilities-Children's Global Assessment Scale (DD-CGAS) as well as biochemical parameters of total vitamin D status (25-hydroxyvitamin D (25(OH)D)), immunity and systemic inflammation. RESULTS:38 children completed the trial. Baseline 25(OH)D was 54.2±19.7 nmol/L. Following vitamin D3 supplementation, there was a significant increase in 25(OH)D to 83.8 nmol/L (p=0.0016) but no effect on the primary endpoint. However, there was an improvement in self-care on DD-CGAS (p=0.02). In contrast, there was also a trend toward decreased inappropriate speech in the placebo group (p=0.08). CONCLUSION:Vitamin D supplementation had no effect on the primary outcome with limited and inconsistent effects in children with ASD. Considering the other promising data as well as the relative safety and cheapness of vitamin D supplementation, further trials are warranted. TRIAL REGISTRATION:NCT02508922.

journal_name

Arch Dis Child

authors

Kerley CP,Power C,Gallagher L,Coghlan D

doi

10.1136/archdischild-2017-312783

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1030-1036

issue

11

eissn

0003-9888

issn

1468-2044

pii

archdischild-2017-312783

journal_volume

102

pub_type

杂志文章,随机对照试验
  • Mothers' reports of infant crying and soothing in a multicultural population.

    abstract:OBJECTIVES:To investigate the prevalence of infant crying and maternal soothing techniques in relation to ethnic origin and other sociodemographic variables. DESIGN:A questionnaire survey among mothers of 2-3 month old infants registered at six child health clinics in Amsterdam, the Netherlands. SUBJECTS:A questionna...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.79.4.312

    authors: van der Wal MF,van den Boom DC,Pauw-Plomp H,de Jonge GA

    更新日期:1998-10-01 00:00:00

  • Thoughts on treatment of strawberry naevi.

    abstract::Published reports on the treatment of large strawberry naevi have been reviewed. It is suggested that they should normally be left untreated, and that corticosteroids, given for a short period only, should be reserved for massive naevi close to the eye, or interfering with respiration or suckling, or associated with t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.51.2.138

    authors: Illingworth RS

    更新日期:1976-02-01 00:00:00

  • Stabilisation of critically ill children at the district general hospital prior to intensive care retrieval: a snapshot of current practice.

    abstract:OBJECTIVE:To describe current practice during stabilisation of children presenting with critical illness to the district general hospital (DGH), preceding retrieval to intensive care. DESIGN:Observational study using prospectively collected transport data. SETTING:A centralised intensive care retrieval service in Eng...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.151266

    authors: Lampariello S,Clement M,Aralihond AP,Lutman D,Montgomery MA,Petros AJ,Ramnarayan P

    更新日期:2010-09-01 00:00:00

  • Epidemiology of facial clefts.

    abstract::Data from the Glasgow Register of Congenital Malformations were used to investigate the epidemiology of congenital facial clefts over the period 1974-85. Facial clefts were registered in 247 infants representing a prevalence of 1.56 per 1000 total births. Cleft palate was more common than cleft lip, with cleft lip and...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.7.717

    authors: Womersley J,Stone DH

    更新日期:1987-07-01 00:00:00

  • Should hepatitis B surface antigen positive mothers breast feed?

    abstract::Breast fed infants may be at greater risk of mother to infant hepatitis B virus infection compared with formula fed infants. We studied 85 infants born to 84 hepatitis B surface antigen positive mothers (only two of whom were hepatitis B e positive), and who had received immunisation against hepatitis B virus. Our res...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.10.972

    authors: de Martino M,Appendino C,Resti M,Rossi ME,Muccioli AT,Vierucci A

    更新日期:1985-10-01 00:00:00

  • Changes in asthma prevalence: two surveys 15 years apart.

    abstract::In 1973 a survey was conducted among 12 year old children living in a defined area of South Wales. In 1988 the survey was repeated in the same area, again among 12 year old children. Questionnaires were completed for all 965 children in the population sample; peak expiratory flow rates were performed on them all, and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.10.1452

    authors: Burr ML,Butland BK,King S,Vaughan-Williams E

    更新日期:1989-10-01 00:00:00

  • The doctor, the father, and the social scientist.

    abstract::Life was sorted. With membership of the college under my belt, and my paediatric training completed, I needed a new challenge. I decided to launch into the deep waters of qualitative research. Stepping out with some trepidation into semistructured interviews and grounded theory, I soon found that the water was neither...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.1.44

    authors: Sidebotham P

    更新日期:2003-01-01 00:00:00

  • Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H(+)-K(+)-ATPase deficiency.

    abstract::We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gast...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.6.504

    authors: Simpson AM,Schwartz GJ

    更新日期:2001-06-01 00:00:00

  • Phase II meningococcal B vesicle vaccine trial in New Zealand infants.

    abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/adc.2007.132571

    authors: Jackson C,Lennon DR,Sotutu VT,Yan J,Stewart JM,Reid S,Crengle S,Oster P,Ypma E,Aaberge I,Mulholland K,Martin DR

    更新日期:2009-10-01 00:00:00

  • Pneumococcal nasopharyngeal carriage in children following heptavalent pneumococcal conjugate vaccination in infancy.

    abstract:AIMS:To ascertain whether the reduction in nasopharyngeal carriage of vaccine serotypes induced by pneumococcal conjugate vaccine (PnCV) administered to infants persists beyond the age of 2 years. METHODS:Non-randomised, unblinded controlled study of 2-5 year old children who had received three doses of heptavalent Pn...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.88.3.211

    authors: Lakshman R,Murdoch C,Race G,Burkinshaw R,Shaw L,Finn A

    更新日期:2003-03-01 00:00:00

  • Minor congenital anomalies and ataxic cerebral palsy.

    abstract::The incidence of minor congenital anomalies was examined in 36 patients with ataxic cerebral palsy, in unaffected family members, and in 100 unrelated control subjects. None of the control subjects or family members had more than four anomalies, and 25 of 36 (69%) of the patients had more than four. The distribution o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.4.557

    authors: Miller G

    更新日期:1989-04-01 00:00:00

  • Concentration of zinc in the hair of schoolchildren.

    abstract::The concentration of zinc in the hair of 219 schoolchildren aged between 10 and 11 years was measured and related to height, weight, estimates of consumption of zinc-rich foods, number of children living at home, and rank in family. None of the correlation coefficients between hair zinc and the other variables was sig...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.12.958

    authors: Heinersdorff N,Taylor TG

    更新日期:1979-12-01 00:00:00

  • Development of a measure to assess the perceived illness experience after treatment for cancer.

    abstract::The development of a scale to measure perceived illness experience in young people with cancer is described. Areas of concern were first identified through semistructured interviews conducted with children and adolescents. As a result, 78 items were generated to cover the main areas identified (physical appearance, in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.4.302

    authors: Eiser C,Havermans T,Craft A,Kernahan J

    更新日期:1995-04-01 00:00:00

  • Beclomethasone dipropionate aerosol in treatment of hay fever in children.

    abstract::Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.50.11.875

    authors: Prahl P,Wilken-Jensen K,Mygind N

    更新日期:1975-11-01 00:00:00

  • Children's access to treatment for epilepsy: experience from the Lao People's Democratic Republic.

    abstract::Epilepsy affects an estimated 10.5 million children worldwide, of whom 80% live in developing countries. The treatment gap is estimated at around 90% in the Lao People's Democratic Republic (Lao PDR). The present work analyses some of the reasons that could explain the low access to antiepileptic drugs (AED) for child...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2009.181255

    authors: Barennes H,Sengkhamyong K,Sambany EM,Koffi PN,Chivorakul P,Empis G,Clavel S,Somphavong S,Wangkou N,Rajaonarivo C,Harimanana A

    更新日期:2011-03-01 00:00:00

  • Treatment related deaths during induction and in first remission in acute lymphoblastic leukaemia: MRC UKALL X.

    abstract::The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to 1990, 1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK were treated on MRC UKALL X with intensive...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/adc.74.2.101

    authors: Wheeler K,Chessells JM,Bailey CC,Richards SM

    更新日期:1996-02-01 00:00:00

  • Resource and outcome in paediatric diabetes services.

    abstract::The availability of resource (staffing and services) in all 21 paediatric diabetes services in Yorkshire and Humber Strategic Health Authority, UK was surveyed and this information was combined with demographic and clinical data on 2683 children and young people with diabetes (aged 0-23 years) to assess whether level ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.198275

    authors: Harron KL,McKinney PA,Feltbower RG,Holland P,Campbell FM,Parslow RC

    更新日期:2012-06-01 00:00:00

  • Comparison of the use of Tanner and Whitehouse, NCHS, and Cambridge standards in infancy.

    abstract::The British (Tanner and Whitehouse) and American (National Center for Health Statistics, NCHS) growth standards are widely used internationally, although the data are now over 30 years old. Routine weight data was retrieved from the child health records of a complete annual cohort of 3418 children aged 18-30 months to...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.4.420

    authors: Wright CM,Waterston A,Aynsley-Green A

    更新日期:1993-10-01 00:00:00

  • Disseminated intravascular clotting in kwashiorkor.

    abstract::The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.308

    authors: Hassanein EA,Tankovsky I

    更新日期:1975-04-01 00:00:00

  • Early detection of abnormalities in partial epilepsy using magnetic resonance.

    abstract::The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.1.104

    authors: Cross JH,Jackson GD,Neville BG,Connelly A,Kirkham FJ,Boyd SG,Pitt MC,Gadian DG

    更新日期:1993-07-01 00:00:00

  • Bacteriological monitoring of unheated human milk.

    abstract::To assess the bacteriological quality of unpooled expressed breast milk, a pilot bottle sample of each donation was examined before the milk was given to the neonate. Provided the milk did not contain greater than 2500 organisms/ml or potential pathogens it was used unheated. Milk containing between 2500 and 5000 orga...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.10.760

    authors: Davidson DC,Poll RA,Roberts C

    更新日期:1979-10-01 00:00:00

  • Simple method for securing umbilical catheters.

    abstract::A method for securing umbilical catheters is described. It has been used successfully in over 350 babies. It is a simple and rapid method that allows for easy repositioning and, unlike some established techniques, has no potential for damage to the preterm baby's skin. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.7_spec_no.750

    authors: South M,Magnay A

    更新日期:1988-07-01 00:00:00

  • The paediatrician and the management of common gynaecological conditions.

    abstract::Paediatric gynaecology is an emerging discipline. Since 2000, there has been an advanced training programme in paediatric gynaecology available for obstetric and gynaecology trainees; additionally, a set of clinical standards 1 for the care of paediatric and adolescent patients has been developed by The British Societ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2017-314375

    authors: Ritchie JK,Latthe P,Jyothish D,Blair JC

    更新日期:2018-07-01 00:00:00

  • The changing UK paediatric consultant workforce: report from the Royal College of Paediatrics and Child Health.

    abstract:OBJECTIVES:To determine if there had been changes in the size of the UK paediatric workforce and working patterns between 1999 and 2013. DESIGN:Analysis of prospectively collected datasets. SETTING:UK consultant paediatricians. INTERVENTIONS:Data from the Royal College of Paediatrics and Child Health's workforce cen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-312055

    authors: McColgan M,Winch R,Clark SJ,Ewing C,Modi N,Greenough A

    更新日期:2017-02-01 00:00:00

  • Pupil size in diabetes.

    abstract::Sympathetic function was studied in 101 diabetic children and 102 age and sex matched control children, as part of a longitudinal study of the evolution of microvascular disease in the population of diabetic children and adolescents in Avon County. The median (range) age of the diabetic population was 13.5 (6.0-17.2) ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.6.511

    authors: Karavanaki K,Davies AG,Hunt LP,Morgan MH,Baum JD

    更新日期:1994-12-01 00:00:00

  • Classification of perinatal death.

    abstract::Three paediatric pathologists, one perinatal paediatrician, one obstetrician, and one epidemiologist separately used information collected on 239 babies in an attempt to validate the Wigglesworth classification of perinatal deaths. This was first done using clinical data only, then using the combination of clinical an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.10_spec_no.1345

    authors: Keeling JW,MacGillivray I,Golding J,Wigglesworth J,Berry J,Dunn PM

    更新日期:1989-10-01 00:00:00

  • Primary antiphospholipid syndrome presenting as complicated Henoch-Schönlein purpura.

    abstract::A child showing signs of Henoch-Schönlein purpura developed a right tibiofibular vascular thrombosis. Antiphospholipid antibody tests were positive for both lupus anticoagulant and anticardiolipin antibodies. This suggests that an antiphospholipid syndrome should be considered in cases of Henoch-Schönlein purpura and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.86.2.132

    authors: Monastiri K,Selmi H,Tabarki B,Yacoub M,Mahjoub T,Essoussi AS

    更新日期:2002-02-01 00:00:00

  • Pharmacological management of abnormal tone and movement in cerebral palsy.

    abstract:BACKGROUND:The evidence base to guide the pharmacological management of tone and abnormal movements in cerebral palsy (CP) is limited, as is an understanding of routine clinical practice in the UK. We aimed to establish details of motor phenotype and current pharmacological management of a representative cohort across ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-316309

    authors: Lumsden DE,Crowe B,Basu A,Amin S,Devlin A,DeAlwis Y,Kumar R,Lodh R,Lundy CT,Mordekar SR,Smith M,Cadwgan J

    更新日期:2019-08-01 00:00:00

  • No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome.

    abstract:OBJECTIVES:To investigate whether meningococcal C conjugate vaccine (MCCV) caused relapse in children with steroid-responsive nephrotic syndrome. DESIGN:A population-based study was conducted using an active surveillance system, developed to assess adverse events following vaccination, which linked hospital record inf...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.105247

    authors: Taylor B,Andrews N,Stowe J,Hamidi-Manesh L,Miller E

    更新日期:2007-10-01 00:00:00

  • Maternal homocystinuria: studies of an untreated mother and fetus.

    abstract::A 20-year-old woman with untreated homocystinuria was examined when she was 18 weeks' pregnant. Amniocentesis was performed and raised levels of homocystine and methionine were present in the amniotic fluid. Assay of cystathionine synthetase activity in cultured amniotic fluid cells showed the carrier state for homocy...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.9.721

    authors: Kurczynski TW,Muir WA,Fleisher LD,Palomaki JF,Gaull GE,Rassin DK,Abramowsky C

    更新日期:1980-09-01 00:00:00