Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway.


:Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. We herein showed that adiponectin and AICAR downregulated MITF, tyrosinase, TRP-1, and DCT expression and reduced melanin content in normal human and mouse melanocytes. The depigmenting effect of adiponectin was mediated via AMPK activation, which induced the inhibitory phosphorylation of CREB-regulated transcription co-activators (CRTCs) and subsequent suppression of the novel CRTC/CREB pathway in melanocytes. These findings suggest that adiponectin and its analogs are useful as a clinical strategy for treating hyperpigmentation disorders.


Bang S,Won KH,Moon HR,Yoo H,Hong A,Song Y,Chang SE




Has Abstract


2017-01-01 00:00:00












  • The avidity of tumor-specific T cells amplified by a plasmacytoid dendritic cell-based assay can predict the clinical evolution of melanoma patients.

    abstract::The advent of immune checkpoint blockers and targeted therapies has changed the outcome of melanoma. However, many patients experience relapses, emphasizing the need for predictive and prognostic biomarkers. We developed a strategy based on plasmacytoid dendritic cells (pDCs) loaded with melanoma tumor antigens that a...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Charles J,Chaperot L,Revol B,Baudin M,Mouret S,Hamon A,Leccia MT,Plumas J,Aspord C

    更新日期:2018-01-01 00:00:00

  • Genetics of human iris colour and patterns.

    abstract::The presence of melanin pigment within the iris is responsible for the visual impression of human eye colouration with complex patterns also evident in this tissue, including Fuchs' crypts, nevi, Wolfflin nodules and contraction furrows. The genetic basis underlying the determination and inheritance of these traits ha...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Sturm RA,Larsson M

    更新日期:2009-10-01 00:00:00

  • Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage.

    abstract::Melanoma incidence continues to rise at an alarming rate while effective systemic therapies remain very limited. Microphthalmia-associated transcription factor (MITF) is required for development of melanocytes and is an amplified oncogene in a fraction of human melanomas. Microphthalmia-associated transcription factor...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Yokoyama S,Feige E,Poling LL,Levy C,Widlund HR,Khaled M,Kung AL,Fisher DE

    更新日期:2008-08-01 00:00:00

  • Genetic variation in regulatory DNA elements: the case of OCA2 transcriptional regulation.

    abstract::Mutations within the OCA2 gene or the complete absence of the OCA2 protein leads to oculocutaneous albinism type 2. The OCA2 protein plays a central role in melanosome biogenesis, and it is a strong determinant of the eumelanin content in melanocytes. Transcript levels of the OCA2 gene are strongly correlated with pig...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Visser M,Kayser M,Grosveld F,Palstra RJ

    更新日期:2014-03-01 00:00:00

  • Melanoma central nervous system metastases: current approaches, challenges, and opportunities.

    abstract::Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here,...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Cohen JV,Tawbi H,Margolin KA,Amravadi R,Bosenberg M,Brastianos PK,Chiang VL,de Groot J,Glitza IC,Herlyn M,Holmen SL,Jilaveanu LB,Lassman A,Moschos S,Postow MA,Thomas R,Tsiouris JA,Wen P,White RM,Turnham T,Davies M

    更新日期:2016-11-01 00:00:00

  • MITF controls the TCA cycle to modulate the melanoma hypoxia response.

    abstract::In response to the dynamic intra-tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the microphthalmia-associated transcription factor (MITF). The response to hypoxia is driven by hypoxia-inducible transcription factors (HIFs) that reprogram metabolism an...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Louphrasitthiphol P,Ledaki I,Chauhan J,Falletta P,Siddaway R,Buffa FM,Mole DR,Soga T,Goding CR

    更新日期:2019-11-01 00:00:00

  • NLRP1, a regulator of innate immunity associated with vitiligo.

    abstract::Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation a...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: D'Osualdo A,Reed JC

    更新日期:2012-01-01 00:00:00

  • Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival.

    abstract::Melanoma is the deadliest form of skin cancer; a primary driver of this high level of morbidity is the propensity of melanoma cells to metastasize. When malignant tumours develop distant metastatic lesions the new local tissue niche is known to impact on the biology of the cancer cells. However, little is known about ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Ferguson J,Wilcock DJ,McEntegart S,Badrock AP,Levesque M,Dummer R,Wellbrock C,Smith MP

    更新日期:2020-01-01 00:00:00

  • Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains.

    abstract::We investigated the contributions of Tyrp1 and Gpnmb to the iris transillumination defect (TID) in five age cohorts of BXD mice. Using systems genetics, we also evaluated the role of other known pigmentation genes (PGs). Mapping studies indicate that Tyrp1 contributes to the phenotype at all ages, yet the TID maps to ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Swaminathan S,Lu H,Williams RW,Lu L,Jablonski MM

    更新日期:2013-07-01 00:00:00

  • Decreased regulatory T-cells and CD4(+) /CD8(+) ratio correlate with disease onset and progression in patients with generalized vitiligo.

    abstract::The aim of present study was to evaluate CD4(+) /CD8(+) ratio and CD4(+) CD25(hi) FoxP3(+) Tregs in GV patients with reference to their effect on disease onset and progression. Flow cytometry was used for determination of CD4(+) /CD8(+) ratio and Tregs in 82 patients and 50 controls. CD8(+) T-cell counts were signific...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Dwivedi M,Laddha NC,Arora P,Marfatia YS,Begum R

    更新日期:2013-07-01 00:00:00

  • BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene.

    abstract::Microphthalmia-associated transcription factor (MITF) is a survival factor in melanocytes and melanoma cells. MITF regulates expression of antiapoptotic genes and promotes lineage-specific survival in response to ultraviolet (UV) radiation and to chemotherapeutics. SWI/SNF chromatin-remodeling enzymes interact with MI...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Saladi SV,Wong PG,Trivedi AR,Marathe HG,Keenen B,Aras S,Liew ZQ,Setaluri V,de la Serna IL

    更新日期:2013-05-01 00:00:00

  • Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma.

    abstract::Oncogenic mutations in BRAF are common in melanoma and drive constitutive activation of the MEK/ERK pathway. To elucidate the transcriptional events downstream of (V600E)BRAF/MEK signalling we performed gene expression profiling of A375 melanoma cells treated with potent and selective inhibitors of (V600E)BRAF and MEK...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Packer LM,East P,Reis-Filho JS,Marais R

    更新日期:2009-12-01 00:00:00

  • Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions.

    abstract::In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma pa...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Glitza IC,Smalley KSM,Brastianos PK,Davies MA,McCutcheon I,Liu JKC,Ahmed KA,Arrington JA,Evernden BR,Smalley I,Eroglu Z,Khushalani N,Margolin K,Kluger H,Atkins MB,Tawbi H,Boire A,Forsyth P

    更新日期:2020-07-01 00:00:00

  • The Dark brown plumage color in chickens is caused by an 8.3-kb deletion upstream of SOX10.

    abstract::The Dark brown (DB) mutation in chickens reduces expression of black eumelanin and enhances expression of red pheomelanin, but only in certain parts of the plumage. Here, we present genetic evidence that an 8.3-kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the DB phenotyp...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Gunnarsson U,Kerje S,Bed'hom B,Sahlqvist AS,Ekwall O,Tixier-Boichard M,Kämpe O,Andersson L

    更新日期:2011-04-01 00:00:00

  • Is it time to test biguanide metformin in the treatment of melanoma?

    abstract::Metformin is the most widely used antidiabetic drug that belongs to the biguanide class. It is very well tolerated and has the major clinical advantage of not inducing hypoglycemia. Metformin decreases hepatic glucose production via a mechanism requiring liver kinase B1, which controls the metabolic checkpoint, AMP-ac...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Cerezo M,Tomic T,Ballotti R,Rocchi S

    更新日期:2015-01-01 00:00:00

  • ABCB5 is activated by MITF and β-catenin and is associated with melanoma differentiation.

    abstract::Defining markers of different phenotypic states in melanoma is important for understanding disease progression, determining the response to therapy, and defining the molecular mechanisms underpinning phenotype-switching driven by the changing intratumor microenvironment. The ABCB5 transporter is implicated in drug-res...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Louphrasitthiphol P,Chauhan J,Goding CR

    更新日期:2020-01-01 00:00:00

  • Insights into genetic alterations of liver metastases from uveal melanoma.

    abstract::The liver is the organ usually affected by metastatic uveal melanoma (MUM). Current treatments are almost always ineffective and mortality remains high. In this study, copy number variations (CNVs) were identified in 12 metastatic and five matched primary UMs (PUMs). Our data revealed a wide spectrum of genetic altera...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: McCarthy C,Kalirai H,Lake SL,Dodson A,Damato BE,Coupland SE

    更新日期:2016-01-01 00:00:00

  • MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.

    abstract::Mice lacking the E3 ubiquitin ligase mahogunin ring finger-1 (MGRN1) have a pleiotropic phenotype that includes spongiform neurodegeneration, embryonic patterning defects, and dark fur due to a defect in pigment-type switching. The only MGRN1 ubiquitination target identified to date is tumor susceptibility gene 101 (T...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Gunn TM,Silvius D,Bagher P,Sun K,Walker KK

    更新日期:2013-03-01 00:00:00

  • The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis.

    abstract::The novel mutation named ru2(d) /Hps5(ru2-d) , characterized by light-colored coats and ruby-eyes, prohibits differentiation of melanocytes by inhibiting tyrosinase (Tyr) activity, expression of Tyr, Tyr-related protein 1 (Tyrp1), Tyrp2, and Kit. However, it is not known whether the ru2(d) allele affects pheomelanin s...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Hirobe T,Ito S,Wakamatsu K

    更新日期:2013-09-01 00:00:00

  • Increasing the complexity: new genes and new types of albinism.

    abstract::Albinism is a rare genetic condition globally characterized by a number of specific deficits in the visual system, resulting in poor vision, in association with a variable hypopigmentation phenotype. This lack or reduction in pigment might affect the eyes, skin, and hair (oculocutaneous albinism, OCA), or only the eye...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Montoliu L,Grønskov K,Wei AH,Martínez-García M,Fernández A,Arveiler B,Morice-Picard F,Riazuddin S,Suzuki T,Ahmed ZM,Rosenberg T,Li W

    更新日期:2014-01-01 00:00:00

  • Beta-catenin regulates melanocyte dendricity through the modulation of PKCzeta and PKCdelta.

    abstract::The Wnt/beta-catenin signaling pathway is involved in the melanocyte differentiation and melanoma development. However, the effect of beta-catenin for dendrite formation has not been clearly elucidated yet in normal human epidermal melanocytes (NHEM). To investigate the effect of beta-catenin, we transduced NHEM with ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Kim JH,Sohn KC,Choi TY,Kim MY,Ando H,Choi SJ,Kim S,Lee YH,Lee JH,Kim CD,Yoon TJ

    更新日期:2010-06-01 00:00:00

  • The 308-nm excimer laser treatment does not increase the risk of skin cancer in patients with vitiligo: A population-based retrospective cohort study.

    abstract::A 308-nm excimer laser (EL) has been widely used to treat patients with localized vitiligo. However, data are rare on the influence of EL treatment on the risks of skin cancer. To evaluate the skin cancer risks after long-term EL treatment, we performed a nationwide population-based retrospective cohort study using th...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Bae JM,Eun SH,Oh SH,Shin JH,Kang HY,Kim KH,Lee SC,Choi CW

    更新日期:2019-09-01 00:00:00

  • Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins.

    abstract::RS-4-(4-Hydroxyphenyl)-2-butanol (rhododendrol, RD) was reported to induce leukoderma of the skin. To explore the mechanism underlying that effect, we previously showed that oxidation of RD with mushroom tyrosinase produces RD-quinone, which is converted to secondary quinone products, and we suggested that those quino...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Ito S,Okura M,Nakanishi Y,Ojika M,Wakamatsu K,Yamashita T

    更新日期:2015-05-01 00:00:00

  • Lighting a path to pigmentation: mechanisms of MITF induction by UV.

    abstract::While sunlight is important for life, ultraviolet radiation (UVR) can have harmful and mutagenic effects. This duality is particularly relevant to human skin, in which UVR both participates in evolutionarily important photochemical reactions yet may act as a potential carcinogen. UVR can upregulate production of melan...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Liu JJ,Fisher DE

    更新日期:2010-12-01 00:00:00

  • Re-evaluation of insect melanogenesis research: Views from the dark side.

    abstract::Melanins (eumelanin and pheomelanin) are synthesized in insects for several purposes including cuticle sclerotization and color patterning, clot formation, organogenesis, and innate immunity. Traditional views of insect immunity detail the storage of pro-phenoloxidases inside specialized blood cells (hemocytes) and th...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Whitten MMA,Coates CJ

    更新日期:2017-07-01 00:00:00

  • Giant congenital melanocytic nevus with vascular malformation and epidermal cysts associated with a somatic activating mutation in BRAF.

    abstract::Giant congenital melanocytic nevi may be symptomatically isolated or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year-old patient with a giant congenital melanocytic nevus (CMN) of the lower back, buttocks, and thighs was asympto...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Etchevers HC,Rose C,Kahle B,Vorbringer H,Fina F,Heux P,Berger I,Schwarz B,Zaffran S,Macagno N,Krengel S

    更新日期:2018-05-01 00:00:00

  • Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer.

    abstract::Genome-wide association studies (GWAS) have become a widely used approach for genetic association studies of various human traits. A few GWAS have been conducted with the goal of identifying novel loci for pigmentation traits, melanoma, and non-melanoma skin cancer. Nevertheless, the phenotype variation explained by t...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Meng S,Zhang M,Liang L,Han J

    更新日期:2012-09-01 00:00:00

  • The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.

    abstract::Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Orlow I,Shi Y,Kanetsky PA,Thomas NE,Luo L,Corrales-Guerrero S,Cust AE,Sacchetto L,Zanetti R,Rosso S,Armstrong BK,Dwyer T,Venn A,Gallagher RP,Gruber SB,Marrett LD,Anton-Culver H,Busam K,Begg CB,Berwick M,GEM Study

    更新日期:2018-03-01 00:00:00

  • Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.

    abstract::Melanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here, we describe the characterization of a panel of 102 cell lines from metastatic melanomas (the NZM lines), in...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章


    authors: Tran KB,Gimenez G,Tsai P,Kolekar S,Rodger EJ,Chatterjee A,Jabed A,Shih JH,Joseph WR,Marshall ES,Wang Q,Print CG,Eccles MR,Baguley BC,Shepherd PR

    更新日期:2021-01-01 00:00:00

  • Advances in melanoma senescence and potential clinical application.

    abstract::Normal cells possess a limited proliferative life span, after which they enter a state of irreversible growth arrest, called replicative senescence, which acts as a potent barrier against transformation. Transformed cells have escaped the process of replicative senescence and theoretically can not re-enter senescence....

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审


    authors: Giuliano S,Ohanna M,Ballotti R,Bertolotto C

    更新日期:2011-04-01 00:00:00