Abstract:
:Hermansky-Pudlak syndrome (HPS) is a rare recessive disorder characterized by hypopigmentation, bleeding diathesis, and other symptoms due to multiple defects in lysosome-related organelles. Ten HPS subtypes have been identified with mutations in HPS1 to HPS10. Only four patients with HPS-1 have been reported in Chinese population. Using next-generation sequencing (NGS), we have screened 100 hypopigmentation genes and identified four HPS-1, two HPS-3, one HPS-5, and three HPS-6 in Chinese HPS patients with typical ocular or oculocutaneous albinism and the absence of platelet dense granules together with other variable phenotypes. All these patients except one homozygote were compound heterozygotes. Among these mutations, 14 were previously unreported alleles (four in HPS1, three in HPS3, two in HPS5, five in HPS6). Our results demonstrate the feasibility and utility of NGS-based panel diagnostics for HPS. Genotyping of HPS subtypes is a prerequisite for intervention of subtype-specific symptoms.
journal_name
Pigment Cell Melanoma Resjournal_title
Pigment cell & melanoma researchauthors
Wei A,Yuan Y,Bai D,Ma J,Hao Z,Zhang Y,Yu J,Zhou Z,Yang L,Yang X,Li L,Li Wdoi
10.1111/pcmr.12534subject
Has Abstractpub_date
2016-11-01 00:00:00pages
702-706issue
6eissn
1755-1471issn
1755-148Xjournal_volume
29pub_type
杂志文章abstract::Melanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here, we describe the characterization of a panel of 102 cell lines from metastatic melanomas (the NZM lines), in...
journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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doi:10.1111/j.1755-148X.2012.00990.x
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
doi:10.1111/j.1755-148X.2009.00616.x
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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abstract::The Dark brown (DB) mutation in chickens reduces expression of black eumelanin and enhances expression of red pheomelanin, but only in certain parts of the plumage. Here, we present genetic evidence that an 8.3-kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the DB phenotyp...
journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
doi:10.1111/j.1755-148X.2011.00825.x
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