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Two light-activated neuroendocrine circuits arising in the eye trigger physiological and morphological pigmentation.

Abstract：

:Two biological processes regulate light-induced skin colour change. A fast 'physiological pigmentation change' (i.e. circadian variations or camouflage) involves alterations in the distribution of pigment containing granules in the cytoplasm of chromatophores, while a slower 'morphological pigmentation change' (i.e. seasonal variations) entails changes in the number of pigment cells or pigment type. Although linked processes, the neuroendocrine coordination triggering each response remains largely obscure. By evaluating both events in Xenopus laevis embryos, we show that morphological pigmentation initiates by inhibiting the activity of the classical retinal ganglion cells. Morphological pigmentation is always accompanied by physiological pigmentation, and a melatonin receptor antagonist prevents both responses. Physiological pigmentation also initiates in the eye, but with repression of melanopsin-expressing retinal ganglion cell activity that leads to secretion of alpha-melanocyte-stimulating hormone (α-MSH). Our findings suggest a model in which eye photoperception links physiological and morphological pigmentation by altering α-MSH and melatonin production, respectively.

journal_name

Pigment Cell Melanoma Res

journal_title

Pigment cell & melanoma research

authors

Bertolesi GE,Hehr CL,Munn H,McFarlane S

doi

10.1111/pcmr.12531

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

688-701

issue

6

eissn

1755-1471

issn

1755-148X

journal_volume

29

pub_type

杂志文章

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