Abstract:
:A 308-nm excimer laser (EL) has been widely used to treat patients with localized vitiligo. However, data are rare on the influence of EL treatment on the risks of skin cancer. To evaluate the skin cancer risks after long-term EL treatment, we performed a nationwide population-based retrospective cohort study using the Korean National Health Insurance Claims Database. A total of 5,052 patients with vitiligo were classified into three groups according to the EL treatment sessions between 2009 and 2016: no, 50-99, and 100 or more EL treatments after 2-year washout period (2007 and 2008). Using multivariable Cox proportional hazard models, we found that the risks of actinic keratosis, non-melanoma skin cancers, and melanoma did not significantly differ among the groups, respectively. In conclusion, EL treatment would not increase the risks of premalignant skin lesions and skin cancers in patients with vitiligo. Based on our results, EL is likely to be a safe treatment option for patients with localized vitiligo.
journal_name
Pigment Cell Melanoma Resjournal_title
Pigment cell & melanoma researchauthors
Bae JM,Eun SH,Oh SH,Shin JH,Kang HY,Kim KH,Lee SC,Choi CWdoi
10.1111/pcmr.12781subject
Has Abstractpub_date
2019-09-01 00:00:00pages
714-718issue
5eissn
1755-1471issn
1755-148Xjournal_volume
32pub_type
杂志文章abstract::The complex genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, including transcripts regulated by either transforming growth factor, beta 1 (TGF...
journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
doi:10.1111/pcmr.12620
更新日期:2018-01-01 00:00:00
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更新日期:2008-02-01 00:00:00
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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journal_title:Pigment cell & melanoma research
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journal_title:Pigment cell & melanoma research
pub_type: 杂志文章
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