Abstract：
:To program a goal-directed response in the presence of acoustic reflections, the audio-motor system should suppress the detection of time-delayed sources. We examined the effects of spatial separation and inter-stimulus delay on the ability of human listeners to localize a pair of broadband sounds in the horizontal plane. Participants indicated how many sounds were heard and where these were perceived by making one or two head-orienting localization responses. Results suggest that perceptual fusion of the two sounds depends on delay and spatial separation. Leading and lagging stimuli in close spatial proximity required longer stimulus delays to be perceptually separated than those further apart. Whenever participants heard one sound, their localization responses for synchronous sounds were oriented to a weighted average of both source locations. For short delays, responses were directed towards the leading stimulus location. Increasing spatial separation enhanced this effect. For longer delays, responses were again directed towards a weighted average. When participants perceived two sounds, the first and the second response were directed to either of the leading and lagging source locations. Perceived locations were interchanged often in their temporal order (in ~40% of trials). We show that the percept of two sounds occurring requires sufficient spatiotemporal separation, after which localization can be performed with high accuracy. We propose that the percept of temporal order of two concurrent sounds results from a different process than localization, and discuss how dynamic lateral excitatory-inhibitory interactions within a spatial sensorimotor map could explain the findings.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
van Bentum GC,van Wanrooij MM,Van Opstal AJdoi
10.1152/jn.00184.2020subject
Has Abstractpub_date
2020-12-30 00:00:00eissn
0022-3077issn
1522-1598pub_type
杂志文章abstract：:The underlying neurophysiology of postural control of the lower back in humans is poorly understood. We have characterized motor unit (MU) discharge activity in the deep lumbar multifidus (LM) muscle in nine healthy subjects (20-40 yr, 3 females). Bilateral fine wire electrodes were implanted at L4 spinal level using ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00010.2014
更新日期：2015-08-01 00:00:00
abstract：:It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00543.2004
更新日期：2005-03-01 00:00:00
abstract：:The role of potassium channels in regulating spontaneous firing and sound-evoked responses in the central nucleus of the inferior colliculus was studied by recording single-unit activity before and during iontophoretic application of a nonspecific potassium channel blocker, tetraethylammonium (TEA). Tone bursts and si...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00730.2003
更新日期：2004-05-01 00:00:00
abstract：:1. A quantal analysis of transmission at the identified molluscan synapse, V2-RPr1, was performed during development. The study was intended to determine the pre- and postsynaptic contributions to the marked changes in transmitter release described in the previous report. 2. The success of the quantal analysis was pre...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1988.60.6.2211
更新日期：1988-12-01 00:00:00
abstract：:1. In the European rock lobster, Homarus gammarus, two bilaterally symmetrical pairs of commissural neurons, P and commissural pyloric (CP), evoke excitatory postsynaptic potentials in the neurons of the pyloric motor network. The present paper shows that the two commissural neurons also exert a modulatory control ove...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.6.2490
更新日期：1994-06-01 00:00:00
abstract：:1. High-voltage-activated Ca2+ currents [ICa(HVA)] were studied in immunolabeled mouse retinal ganglion neurons (RGNs) to elucidate channel-specific components and their developmental changes in vitro. 2. Neurons were dissociated at postnatal day 5. RGNs were selected for electrophysiological measurements by vital lab...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.5.2542
更新日期：1994-11-01 00:00:00
abstract：:A stratified organization of visual, somatic and acoustic representations was observed in the cat SC. Cells of the superficial laminae were exclusively visual. Visual, somatic, and acoustic cells were observed in the intermediate laminae while the deeper laminae were predominantly nonvisual. A detailed examination of ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1976.39.2.401
更新日期：1976-03-01 00:00:00
abstract：:The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that a...
journal_title：Journal of neurophysiology
pub_type： 杂志文章,评审
doi：10.1152/jn.00067.2017
更新日期：2017-08-01 00:00:00
abstract：:Individuals with chronic spinal cord injury (SCI) often demonstrate multijoint reflex activity that is clinically classified as an extensor spasm. These responses are commonly observed in conjunction with an imposed extension movement of the hips, such as movement from a sit to a supine position. Coincidentally, affer...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00677.2003
更新日期：2004-08-01 00:00:00
abstract：:1. Spontaneous saccades, vestibuloocular responses (VOR), and optokinetic nystagmus were recorded in three squirrel monkeys before and after chemical or electrolytic lesion of the posterior commissure (PC). 2. PC lesions produced abnormal vertical eye movements, in particular, 1) Postsaccadic drifts, and 2) VOR gain r...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.6.2582
更新日期：1994-06-01 00:00:00
abstract：:Expression of the 5-HT(1Apl(a)) receptor in Aplysia pleural sensory neurons inhibited 5-HT-mediated translocation of the novel PKC Apl II in sensory neurons and prevented PKC-dependent synaptic facilitation at sensory to motoneuron synapses (Nagakura et al. 2010). We now demonstrate that the ability of inhibitory rece...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00767.2011
更新日期：2012-01-01 00:00:00
abstract：:1. We present a new mathematical description of the complete distribution of electrical responses to stochastic synaptic activity (quantal analysis) that is intended as a model of experiments on central neuronal synapses. Unlike previous treatments, this distribution is calculated for each instant after the release of...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.3.1395
更新日期：1994-09-01 00:00:00
abstract：:1. Fifty-nine rubromotoneuronal (RM) cells were identified in two rhesus monkeys on the basis of their postspike facilitation (PSpF) of rectified electromyographic (EMG) activity. These cells were studied in relation to a step tracking task requiring wrist movements between fixed target zones in flexion and extension....
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.1.14
更新日期：1994-07-01 00:00:00
abstract：:It is well established that orderly patterns of motor neuron activity, muscle recruitment, and limb movement are generated in chicks during motility by embryonic day (E)9, the midpoint in embryonic development. However, our recent work suggests that some attributes of motility, such as the rhythm of repetitive limb mo...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00393.2003
更新日期：2003-09-01 00:00:00
abstract：:Arrays of closely spaced quartz-insulated, platinum-tungsten microelectrodes are widely used to obtain acute recordings from chronically prepared subjects. These electrodes have excellent recording characteristics and can be fabricated to a wide variety of tip specifications. Typically, in such experiments, electrodes...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01141.2004
更新日期：2005-05-01 00:00:00
abstract：:Thalamocortical neurons integrate sensory and cortical activity and are regulated by input from inhibitory neurons in the thalamic reticular nucleus. Evidence suggests that during bursts of action potentials, dendritic calcium transients are seen throughout the dendritic tree of thalamocortical cells. Here, we review ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章,评审
doi：10.1152/jn.00918.2013
更新日期：2014-11-01 00:00:00
abstract：:We report a novel phenomenon produced by focused ultrasound (US) that may be important for understanding its effects on cell membranes. When a US burst (2.1 MHz, 1-mm focal diameter, 0.1-1 MPa) was focused on a motor axon of the crayfish neuromuscular junction, it consistently produced a fast hyperpolarization, which ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00541.2018
更新日期：2019-02-01 00:00:00
abstract：:We investigated the precision of spike timing in a model of gap junction-coupled oscillatory neurons. The model incorporated the known physiology, morphology, and connectivity of the weakly electric fish's high-frequency and extremely precise pacemaker nucleus (Pn). Two neuron classes, pacemaker and relay cells, were ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.2.984
更新日期：2000-02-01 00:00:00
abstract：:Modulation of sacral spinal dorsal horn neurons by the ventrolateral PAG was studied by extracellular recording combined with microiontophoretic applications of alpha-adrenergic agonists or antagonists. Bicuculline (BIC, 15 ng) microinjected into the ventrolateral PAG produced a consistent inhibition of the responses ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.80.5.2244
更新日期：1998-11-01 00:00:00
abstract：:Paired associative stimulation (PAS) based on Hebb's law of association can induce plastic changes in the intact human. The optimal interstimulus interval (ISI) between the peripheral nerve and transcranial magnetic stimulus is not known for muscles of the lower leg. The aims of this study were to investigate the effe...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01176.2006
更新日期：2007-03-01 00:00:00
abstract：:The horizontal angular vestibuloocular reflex (VOR) evoked by high-frequency, high-acceleration rotations was studied in four squirrel monkeys after unilateral labyrinthectomy. Spontaneous nystagmus was measured at the beginning and end of each testing session. During the period that animals were kept in darkness (4 d...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.5.2482
更新日期：2000-05-01 00:00:00
abstract：:In the region of the ventral respiratory group in brain stem slices from neonatal rats, intracellular pH (pHi) and membrane currents (I(m)) or potentials were measured in neurons dialyzed with the pH-sensitive dye 2',7'-bis-carboxyethyl-5(6)-carboxyfluorescein. Currents and increases in membrane conductance (g(m)) dur...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.77.4.1844
更新日期：1997-04-01 00:00:00
abstract：:Visual object information is conveyed from V1 to area TE along the ventral visual pathway with increasing receptive field (RF) sizes. The RFs of TE neurons are known to be large, but it is largely unknown how large RFs are shaped along the ventral visual pathway. In this study, we addressed this question in two aspect...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00348.2017
更新日期：2017-10-01 00:00:00
abstract：:Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular dri...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00437.2018
更新日期：2019-02-01 00:00:00
abstract：:A tool or probe often functions as an extension of the hand, transmitting vibrations to the hand to produce a percept of the object contacting the tool or probe. This paper reports the psychophysical results of a combined psychophysical and neurophysiological study of the perception of vibration transmitted through a ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.81.4.1548
更新日期：1999-04-01 00:00:00
abstract：:Central pattern generator (CPG) motor circuits underlying rhythmic behaviors provide feedback to the projection neuron inputs that drive these circuits. This feedback elicits projection neuron bursting linked to CPG rhythms. The brief periodic interruptions in projection neuron activity in turn influence CPG output, g...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00772.2016
更新日期：2017-08-01 00:00:00
abstract：:1. Adaptation and disadaptation rates determine the temporal response properties of sensory receptor cells. In chemoreception, temporal filter properties of receptor cells are poorly understood. We studied the time course of disadaptation in lobster antennular chemoreceptor cells by using in situ high-resolution stimu...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.2.1340
更新日期：1996-08-01 00:00:00
abstract：:Such perisaccadic mislocalization is maximal in the direction of the saccade and varies systematically with the target-saccade onset delay. We have recently shown that under head-fixed conditions perisaccadic errors do not follow the quantitative predictions of current visuomotor models that explain these mislocalizat...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90276.2008
更新日期：2008-10-01 00:00:00
abstract：:1. High-threshold Ca2+ currents were studied in large pyramidal cells acutely dissociated from the rat amygdaloid complex. L-, N-, and P-type currents were present in about equal proportions in these cells and accounted for most of the whole-cell current. ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.1.433
更新日期：1994-01-01 00:00:00
abstract：:In the orbitofrontal olfactory area (LPOF) which was delineated in a previous paper, the capacity for odor discrimination was studied and compared with that in the anterior pyriform cortex (AP), the medial portion of the amygdala (MA), and the olfactory bulb (OB). Unanesthetized monkeys were used and eight odors were ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1975.38.5.1284
更新日期：1975-09-01 00:00:00
