Abstract:
:Microsleeps are brief episodes of arousal level decrease manifested through behavioral signs. Brain activity during microsleep in the presence of external stimulus remains poorly understood. In this study, we sought to understand neural responses to auditory stimulation during microsleep. We gave participants the simple task of listening to audios of different pitches and amplitude modulation frequencies during early afternoon functional MRI scans. We found the following: 1) microsleep was associated with cortical activations in broad motor and sensory regions and deactivations in thalamus, irrespective of auditory stimulation; 2) high and low pitch audios elicited different activity patterns in the auditory cortex during awake but not microsleep state; and 3) during microsleep, spatial activity patterns in broad brain regions were similar regardless of the presence or types of auditory stimulus (i.e., stimulus invariant). These findings show that the brain is highly active during microsleep but the activity patterns across broad regions are unperturbed by auditory inputs.NEW & NOTEWORTHY During deep drowsy states, auditory inputs could induce activations in the auditory cortex, but the activation patterns lose differentiation to high/low pitch stimuli. Instead of random activations, activity patterns across the brain during microsleep appear to be structured and may reflect underlying neurophysiological processes that remain unclear.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Yong Z,Tan JH,Hsieh PJdoi
10.1152/jn.00825.2018subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2568-2575issue
6eissn
0022-3077issn
1522-1598journal_volume
122pub_type
杂志文章abstract::Echolocating bats use echoes of their sonar emissions to determine the position and distance of objects or prey. Target distance is represented as a map of echo delay in the auditory cortex (AC) of bats. During a bat's flight through a natural complex environment, echo streams are reflected from multiple objects along...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00860.2016
更新日期:2017-06-01 00:00:00
abstract::1. We used period/amplitude (PA) analysis to survey electroencephalography (EEG) across vigilance states in the Sprague-Dawley rat. We found a fast cortical EEG frequency band, which we designate rho, whose wave amplitude in rapid eye movement (REM) was elevated above the levels in both waking and nonrapid eye movemen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.4.1368
更新日期:1993-04-01 00:00:00
abstract::We studied the properties of voltage-activated outward currents in two types of spider cuticular mechanoreceptor neurons to learn if these currents contribute to the differences in their adaptation properties. Both types of neurons adapt rapidly to sustained stimuli, but type A neurons usually only fire one or two act...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.6.2937
更新日期:1999-06-01 00:00:00
abstract::We used laser scanning photostimulation through a focused UV laser of caged glutamate in an in vitro slice preparation through the rat's somatosensory thalamus to study topography and connectivity between the thalamic reticular nucleus and ventral posterior lateral nucleus. This enabled us to focally stimulate the som...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00206.2005
更新日期:2005-10-01 00:00:00
abstract::During early brain development, γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, has been thought to be an important source of excitatory neurotransmission. This view, however, was recently challenged by a series of studies that claim that the excitatory effect of GABA is due to non...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00293.2011
更新日期:2011-09-01 00:00:00
abstract::cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) are two major modulators of synaptic transmission in the CNS but little is known about how they affect synaptic transmission in the human CNS. In this study, we used forskolin, a PKA activator, and phorbol ester, a PKC activator, to examine the effects of ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01031.2002
更新日期:2003-05-01 00:00:00
abstract::The somatosensory temporal discrimination threshold (STDT) has been used in recent years to investigate time processing of sensory information, but little is known about the physiological correlates of somatosensory temporal discrimination. The objective of this study was to investigate whether the time interval requi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00947.2016
更新日期:2017-10-01 00:00:00
abstract::ACh modulates neuronal activity throughout the cerebral cortex, including the primary visual cortex (V1). However, a number of issues regarding this modulation remain unknown, such as the effect and its function and the receptor subtypes involved. To address these issues, we combined extracellular single-unit recordin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00330.2011
更新日期:2012-01-01 00:00:00
abstract::Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na(+)-gated nonselective cation channel. The Na(+)-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagon...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00990.2004
更新日期:2005-03-01 00:00:00
abstract::1. A quantitative analysis of facilitation during the kindling stimulation to the amygdala was conducted by measuring the area between the excitatory potential and the baseline in the averaged tetanic response recorded at the entorhinal cortex. The changes in facilitation were then compared with the development of ele...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.70.2.602
更新日期:1993-08-01 00:00:00
abstract::1. The simplicity of the jellyfish nervous system makes it an ideal preparation to assess the contributions of different ion channels to behavior. In the giant motor axons of the jellyfish Aglantha digitale, low-threshold spikes elicit slow swimming, whereas escape swimming depends on a higher-threshold, overshooting ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.3.894
更新日期:1993-03-01 00:00:00
abstract::Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain. We have investigated the responses of lumbar spinal wide dynamic range (WDR)-type dorsal horn neurons to intracutaneous (ic) microinjection of ni...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.6.3046
更新日期:1999-12-01 00:00:00
abstract::1. In the intact pond snail Planorbis corneus, a rapid tilt in any plane evoked a defense reaction consisting of a fast movement of the shell towards the head, shortening of the foot, inhibition of locomotion and of rhythmical feeding movements. This reaction was similar to the first phase of the general defense react...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.3.898
更新日期:1994-03-01 00:00:00
abstract::The discovery that neuroligin is a key protein involved in synapse formation offers the unprecedented opportunity to induce functional synapses between neurons and heterologous cells. We took this opportunity recording for the first-time synaptic currents in human embryonic kidney 293 (HEK293) cells transfected with n...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00647.2003
更新日期:2003-12-01 00:00:00
abstract::Action potential firing rates are generally limited by the refractory period, which depends on the recovery from inactivation of voltage-gated Na channels. In cerebellar Purkinje neurons, the kinetics of Na channels appear specialized for rapid firing. Upon depolarization, an endogenous open-channel blocker rapidly te...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00261.2004
更新日期:2004-11-01 00:00:00
abstract::The vestibular system operates in a push-pull fashion using signals from both labyrinths and an intricate bilateral organization. Unilateral vestibular lesions cause well-characterized motor deficits that are partially compensated over time and whose neural correlates have been traced in the mean response modulation o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00280.2014
更新日期:2014-08-15 00:00:00
abstract::Working memory (WM) for sensory-based information about individual objects and their locations appears to involve interactions between lateral prefrontal and sensory cortexes. The mechanisms and representations for maintenance of more abstract, nonsensory information in WM are unknown, particularly whether such active...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00134.2014
更新日期:2014-10-15 00:00:00
abstract::Postembryonic developmental changes in electrophysiological properties of the AIY interneuron class were investigated using whole cell voltage clamp. AIY interneurons displayed an increase in cell capacitance during larval development, whereas steady-state current amplitude did not increase. The time course of the out...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00052.2006
更新日期:2006-06-01 00:00:00
abstract::To examine the activity of somatosensory cortex (S1) neurons to self-generated shear forces on the index and thumb, two monkeys were trained to grasp a stationary metal tab with a key grip and exert forces without the fingers slipping in one of four orthogonal directions for 1 s. A majority (∼85%) of slowly adapting a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00749.2014
更新日期:2016-01-01 00:00:00
abstract::Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular calcium, which has motivated recent computational work that employs such fluctuations in an info...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.3.1329
更新日期:2000-03-01 00:00:00
abstract::Inner ear hair cell afferent fiber synapses are capable of transferring information at high rates for long periods of time with extraordinary fidelity. As at other sensory synapses, hair cells rely on graded receptor potentials and unique vesicle trafficking and release properties of ribbon synapses to relay intensity...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00121.2013
更新日期:2013-07-01 00:00:00
abstract::Damage to the cerebellum causes characteristic movement abnormalities but is thought to have minimal impact on somatosensory perception. Traditional clinical assessments of patients with cerebellar lesions reveal no perceptual deficits despite the fact that the cerebellum receives substantial somatosensory information...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00983.2011
更新日期:2012-03-01 00:00:00
abstract::We charted postnatal changes in the intrinsic electrophysiological properties and synaptic responses of rat intrinsic cardiac ganglion (ICG) neurons. We developed a whole-mount ganglion preparation of the excised right atrial ganglion plexus. Using intracellular recordings and nerve stimulation we tested the hypothesi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01220.2005
更新日期:2006-06-01 00:00:00
abstract::1. The purpose of this study is to define the cortical regions that subserve voluntary saccadic eye movements and spatial working memory in humans. 2. Regional cerebral blood flow (rCBF) during performance of oculomotor tasks was measured with [15O]-H2O positron emission tomography (PET). Eleven well-trained, healthy ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.1.454
更新日期:1996-01-01 00:00:00
abstract::Single-channel recording techniques were used to characterize mechanosensitive channels in identified (1.1'-dioctadecyl-3,3,3', 3'-tetramethylindocarbocyanine methanesulfonate labeled) colon sensory neurons dissociated from adult S1 dorsal root ganglia. Channels were found in 30% (7/23) of patches in a cell-attached c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.2.836
更新日期:2000-08-01 00:00:00
abstract::1. In four human subjects, we measured the latency of saccadic eye movements made to a second, eccentric target after an initial, foveated target was extinguished. In separate interleaved trails, the targets were either both stationary ("fixation") or both moving with the same velocity ("pursuit"). For both fixation a...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1152/jn.1996.76.6.4175
更新日期:1996-12-01 00:00:00
abstract::1. Baclofen increases transient light responses of amacrine and ganglion cells despite acting as a classical inhibitory transmitter to both hyperpolarize and shunt these cells. 2. This effect seems to occur at the level of the inner retina and appears not to be due to an additional input from bipolar cells. 3. In some...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.61.2.382
更新日期:1989-02-01 00:00:00
abstract::Homosynaptic long-term depression (LTD) of synaptic efficacy was induced in field excitatory postsynaptic potentials by administration of 900 pulses at either 1 or 3 Hz in 2- to 3-wk-old Sprague-Dawley rats. The stimulation was administered via a bipolar stimulating electrode placed immediately adjacent to the recordi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.3.1651
更新日期:1997-03-01 00:00:00
abstract::The abilities of humans to discriminate the softness of rubber objects of differing compliance with a hand-held tool (a stylus) was measured under experimental conditions that differed as to how the tool was used and the kind of sensory information available. When the subject actively tapped or pressed the compliant o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.4.1777
更新日期:2000-04-01 00:00:00
abstract::The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00067.2017
更新日期:2017-08-01 00:00:00