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Ovine trophoblasts express cathelicidin host defence peptide in response to infection.

Abstract：

:Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placental trophoblast in ovine host defence remains poorly understood. This study characterises expression of genes for cathelicidin and defensin peptides in primary ovine placental tissues, the ovine trophoblast cell line (AH-1) and in response to the TLR-4 ligand LPS, the abortifacient organism Waddlia chondrophila and 1α,25-dihydroxyvitamin D3. Using RT-PCR, expression of the CHDP SMAP-29, sBD-1 and sBD-2 was assessed in the AH-1 cell line in response to LPS, 1α,25-dihydroxyvitamin D3 exposure (a known stimulator of cathelicidin gene expression), or W. chondrophila infection. Expression of cathelicidin in the trophoblast compartment of the ovine placenta and in the ovine trophoblast cell line (AH-1) was also established. AH-1 cells did not upregulate expression of CHDP in response to LPS, but sBD-1 and sBD-2 expression was significantly increased in response to W. chondrophila infection. SMAP-29 expression was not altered by in vitro exposure to 1α,25-dihydroxyvitamin D3. This study demonstrates that the ovine trophoblast expresses cathelicidins, but does not upregulate expression of CHDP in response to LPS. Ovine trophoblasts are shown to differentially regulate expression of CHDP and lack a demonstrable vitamin D-mediated cathelicidin response.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Coyle C,Wheelhouse N,Jacques M,Longbottom D,Svoboda P,Pohl J,Duncan WC,Rae MT,Barlow PG

doi

10.1016/j.jri.2016.06.006

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

10-6

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(16)30013-4

journal_volume

117

pub_type

杂志文章

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