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Serum leptin level in women with unexplained infertility.

Abstract：

INTRODUCTION:The aim of this study was to compare serum levels of leptin in women with unexplained infertility with fertile subjects. MATERIAL AND METHOD:Serum leptin levels of 27 infertile and 30 fertile women on day 3 of the menstrual cycle were assessed and compared in this prospective age and body mass index (BMI) comparable controlled study. RESULTS:The mean age in the infertile group was 29.3 (range, 23-38), while this figure was 28.9 (range, 19-39) in the fertile group; the mean BMIs were 24.5 (range, 20.6-27.8) and 25.0 (range, 21.8-28.7), respectively. The mean serum leptin level was significantly higher in women with unexplained infertility compared with fertile subjects. Considering normal weight subjects, mean serum leptin levels were increased significantly in the unexplained infertile group compared with the fertile group (7.2 (range, 4.3-10.4) versus 3.5 (range, 1.9-6.2)ng/ml, respectively; p<0.0001, Mann-Whitney U-test). The significant increase in serum leptin levels was observed also in overweight patients (6.8 (range, 1.3-5.2) versus 3.3 (range, 4.2-8.9)ng/ml, respectively; p<0.0001, Mann-Whitney U-test). CONCLUSION:A significant difference in serum leptin levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Demir B,Guven S,Guven ES,Atamer Y,Gunalp GS,Gul T

doi

10.1016/j.jri.2007.04.001

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

145-9

issue

2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(07)00087-3

journal_volume

75

pub_type

杂志文章

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