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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction.

Abstract：

BACKGROUND:The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas. PATIENTS AND METHODS:We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used. RESULTS:A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed. CONCLUSION:Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Meister S,Kolben T,Beyer S,Hutter S,Hofmann S,Kuhn C,Messner J,Mayr D,Solano ME,Jegen M,Obermeier V,Mahner S,Arck P,Jeschke U

doi

10.1016/j.jri.2020.103124

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

103124

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(20)30045-0

journal_volume

139

pub_type

杂志文章

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