Abstract:
:During syngeneic pregnancy the numbers of 'spontaneously' occurring ('background') Ig-secreting cells were determined in the spleen, bone marrow (BM) and mesenteric lymph nodes (MLN) of BALB/c mice that were kept under germfree conditions and fed a low molecular weight synthetic diet (GF-CD), SPF BALB/c mice fed autoclaved natural ingredient (SPF-NI) and conventional BALB/c mice fed natural ingredient (CV-NI). 'Background' Ig-secreting cells were enumerated in the protein A plaque assay and the specificity repertoire of the IgM-secreting cells was determined with plaque assays specific for differently haptenized sheep red blood cells (SRBC). The numbers of 'background' Ig-secreting cells, especially the IgG- and IgA-secreting cells, are very much reduced in the BM and MLN of GF-CD mice as compared to SPF-NI and CV-NI mice. During pregnancy the total number of Ig-secreting cells increased in all lymphoid organs tested, but the proportional increase was most prominent for the IgG- and IgA-secreting cells in the BM and MLN of the GF-CD mice. This increase could only be due to their pregnant state since all environmental antigenic influences are excluded in GF-CD mice. No changes were found in the background specificity repertoire of the IgM-secreting cells during pregnancy. This suggests a polyclonal activation of the Ig-secreting cells during pregnancy. The reason for this activation remains obscure, but it has to be endogenous. Pregnancy apparently induces a new steady state of the immune system, which can be most properly investigated in GF-CD mice.
journal_name
J Reprod Immunoljournal_title
Journal of reproductive immunologyauthors
Bos NA,Benner R,Wostmann BS,Pleasants JRdoi
10.1016/0165-0378(86)90017-3subject
Has Abstractpub_date
1986-11-01 00:00:00pages
237-46issue
3eissn
0165-0378issn
1872-7603pii
0165-0378(86)90017-3journal_volume
9pub_type
杂志文章abstract::For many years, experience has been accumulated on embryo and gamete manipulation in livestock animals. The present work is a review of these techniques and their possible application in human embryology in specific cases. It is possible to manipulate gametes at different levels, producing paternal or maternal haploid...
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更新日期:1996-10-01 00:00:00
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更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章,评审
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更新日期:1990-08-01 00:00:00
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journal_title:Journal of reproductive immunology
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更新日期:2014-03-01 00:00:00
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更新日期:1998-08-01 00:00:00
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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更新日期:2015-02-01 00:00:00