Autoantibody screening for infertility: explaining the unexplained?

abstract：:Various ELISA methods have been applied by different research centers to test the efficiency of this approach for the diagnosis of sperm-immune infertility cases. The antigens used were either whole spermatozoa or solubilized spermatozoal membrane preparations and were immobilized on microtiter plates, except in one c...

journal_title：Journal of reproductive immunology

authors： Mettler L,Czuppon AB,Alexander N,D'Almeida M,Haas GG Jr,Hjort T,Møller Jensen J,Ing R,Jones WR,Wang SX

更新日期：1985-12-01 00:00:00

abstract：:Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptiona...

journal_title：Journal of reproductive immunology

authors： Morales Prieto DM,Markert UR

更新日期：2011-03-01 00:00:00

abstract：:Viviparity has many evolutionary advantages but brings with it the problem of the semi-allogeneic foetus having to coexist with the mother for the duration of pregnancy. In species with haemochorial placentation this problem is particularly evident as foetal trophoblast cells are extensively intermingled with maternal...

journal_title：Journal of reproductive immunology

authors： Hemberger M

更新日期：2013-03-01 00:00:00

abstract：:The sequence of biochemical and molecular events associated with decidualization in the primate remain unclear. In the baboon, the sequential changes during this period in vivo are characterized by the downregulation of alpha-smooth actin followed by induction of cyclooxygenase-2 (COX-2) at the implantation site and t...

journal_title：Journal of reproductive immunology

authors： Strakova Z,Srisuparp S,Fazleabas AT

更新日期：2002-05-01 00:00:00

abstract：:In addition to natural killer cells, other innate lymphoid cells have recently been identified in the mouse and human uterus, but their roles in successful pregnancy remain poorly defined. In this study, we examined the dynamic changes of uterine innate lymphoid cells throughout pregnancy in mice. We found that the to...

journal_title：Journal of reproductive immunology

authors： Li M,Gao Y,Yong L,Huang D,Shen J,Liu M,Ren C,Hou X

更新日期：2017-09-01 00:00:00

abstract：:A high resolution two dimensional electrophoretic technique (2-D), isoelectric focusing followed by polyacrylamide gel electrophoresis, for separation of neutral and acidic human spermatozoal proteins was established. Silver stained 2-D gels revealed over 260 proteins with Mr 20-200 kDa and pI between 4.5 and 7.8. Mem...

journal_title：Journal of reproductive immunology

authors： Naaby-Hansen S

更新日期：1990-06-01 00:00:00

abstract：:To analyze immunomodulating effects related to parity status, we studied trophoblast invasion grade, placental expression and systemic concentration of VEGF and its receptor Flt-1 in normal fertile (CBA/JxBALB/c) mice and abortion-prone (CBA/JxDBA/2) H-2(d)xH-2(k) mice. BALB/c or DBA/2 mated CBA/J females were, respec...

journal_title：Journal of reproductive immunology

authors： Litwin S,Cortina ME,Barrientos GL,Prados MB,Roux ME,Miranda SE

更新日期：2010-06-01 00:00:00

abstract：:Recurrent implantation failure (RIF) refers to cases in which women have had the failure of the embryo implantation after several in vitro fertilization (IVF). The success rate for IVF depends on many different factors. Implantation is a complex step in a successful pregnancy. Antiphospholipid antibodies (aPLs) and pl...

journal_title：Journal of reproductive immunology

authors： Mahdian S,Pirjani R,Favaedi R,Movahedi M,Moini A,Shahhoseini M

更新日期：2021-02-01 00:00:00

abstract：:Gammadelta T cells are a prominent granulated cell population in the ruminant pregnant uterus and both their number and granule size increase dramatically during pregnancy. Anchor-RT-PCR was used to assess TCRdelta gene usage by gammadelta T cells from the uterine epithelium of pregnant sheep. The TCRdelta genes obtai...

journal_title：Journal of reproductive immunology

authors： Fox A,Maddox JF,de Veer MJ,Meeusen EN

更新日期：2010-01-01 00:00:00

abstract：:We have previously shown that progesterone-treated lymphocytes of healthy pregnant women can produce a 34 kDa protein, progesterone-induced blocking factor (PIBF) capable of blocking lymphocyte function in vitro. Lymphocytes of women with idiopathic threatened pre-term delivery failed to produce this factor. On the as...

journal_title：Journal of reproductive immunology

authors： Szekeres-Bartho J,Varga P,Pejtsik B

更新日期：1989-09-01 00:00:00

abstract：:The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

journal_title：Journal of reproductive immunology

authors： Hammer A,Dohr G

更新日期：2000-03-01 00:00:00

abstract：:CD14, the major receptor for bacterial lipopolysaccharide (LPS) as well as other microbial antigens, is a component of the innate immune system. We hypothesized that a single nucleotide C>T polymorphism at position -159 in the CD14 gene that results in elevated CD14 production would influence susceptibility to preterm...

journal_title：Journal of reproductive immunology

authors： Kalish RB,Vardhana S,Normand NJ,Gupta M,Witkin SS

更新日期：2006-06-01 00:00:00

abstract：:The levels of rabbit alpha-foetoprotein (RAFP) in foetal serum, neonatal serum and amniotic fluid during gestation have been evaluated by quantitative radial immunodiffusion. RAFP attained its peak concentration on the 24th day of pregnancy in foetal serum, while in amniotic fluid peaks were observed on ;the 14th and...

journal_title：Journal of reproductive immunology

authors： Clarke LE

更新日期：1980-11-01 00:00:00

abstract：:Natural killer (NK) cells comprise of ∼70% of the immune cell population in the maternal decidua and ∼15% of the mononuclear cells in the peripheral blood. The decidual NK cells capable of producing high levels of cytokines are functionally distinct from the peripheral NK cells that exhibit high cytotoxicity. The numb...

journal_title：Journal of reproductive immunology

authors： Dixit A,Karande AA

更新日期：2020-02-01 00:00:00

abstract：:Several members of the immunoglobulin-like transcript (ILT), also called leukocyte immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon binding of these ligands. The ligands for ILT2 (LIR1/CD...

journal_title：Journal of reproductive immunology

authors： Petroff MG,Sedlmayr P,Azzola D,Hunt JS

更新日期：2002-07-01 00:00:00

abstract：:Pregnancy-induced hypertension (PIH) can be complicated by maternal or fetal thrombocytopenia, or both. In order to investigate possible immunologic causes of these thrombocytopenias, platelet-associated IgG (PAIgG) and IgM (PAIgM) were measured in mothers with PIH and in their infants and compared with those from pat...

journal_title：Journal of reproductive immunology

authors： Rote NS,Lau RJ,Harrison MR,Branch DW,Scott JR

更新日期：1987-04-01 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by ...

journal_title：Journal of reproductive immunology

authors： Parr MB,Parr EL

更新日期：1997-11-30 00:00:00

abstract：:Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the pr...

journal_title：Journal of reproductive immunology

authors： Schnabel A,Blois SM,Meint P,Freitag N,Ernst W,Barrientos G,Conrad ML,Rose M,Seelbach-Göbel B

更新日期：2016-04-01 00:00:00

abstract：:We sought to determine whether cytokine expression in peripheral blood mononuclear cells is altered in patients with preeclampsia and in patients with a history of recurrent spontaneous abortion (RSA). Twenty-four patients with preeclampsia and twenty patients with a history of RSA were included into the study. Two co...

journal_title：Journal of reproductive immunology

authors： Rein DT,Schondorf T,Gohring UJ,Kurbacher CM,Pinto I,Breidenbach M,Mallmann P,Kolhagen H,Engel H

更新日期：2002-03-01 00:00:00

abstract：:Prolactin (PRL) was originally identified by its ability to stimulate mammary development and lactation, and its essential roles other than lactation have recently been implicated in female reproduction. However, little is known about PRL-mediated events in pregnancy. The tryptophan catabolism enzyme indoleamine 2,3-d...

journal_title：Journal of reproductive immunology

authors： Kawaguchi R,Shimokawa T,Umehara N,Nunomura S,Tanaka T,Ra C

更新日期：2008-04-01 00:00:00

abstract：:Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently r...

journal_title：Journal of reproductive immunology

authors： Pavlová T,Novák J,Bienertová-Vašků J

更新日期：2015-11-01 00:00:00

abstract：:For some time, reproductive immunologists have worked to understand the balance between maternal tolerance of the fetus, maternal health, and fetal protection which leads to successful pregnancy in mammalian species. We have always understood the potential importance of multiple factors, including nutrition, genetics,...

journal_title：Journal of reproductive immunology

authors： Bonney EA

更新日期：2017-09-01 00:00:00

abstract：:Substrains of BALB/c mice differ in their susceptibility to experimental autoimmune orchitis (EAO), with BALB/cJ representative of the non-responders and BALB/cBy representative of the responders. We examined whether the susceptibility of these two substrains could be altered by reciprocal adoptive transfer of lymphoi...

journal_title：Journal of reproductive immunology

authors： Mahi-Brown CA,Tung KS

更新日期：1990-10-01 00:00:00

abstract：:The proportion of stromal cells expressing DR antigens of the HLA system or reacting with an anti-macrophage antibody was studied by immunohistochemical methods in human proliferative, secretory and post-menopausal endometria. DR+ cells showed a rounded morphology with short expansions and represented 13-25% of the st...

journal_title：Journal of reproductive immunology

authors： Laguens G,Goñi JM Jr,Laguens M,Goñi JM,Laguens R

更新日期：1990-09-01 00:00:00

abstract：:A quantitative immunohistochemical study of IgA-containing plasma cells in the human uterine cervix has shown that the number of such cells increases during the late secretory phase of the menstrual cycle but decreases in the early secretory phase of the cycle, in pregnancy, in cystic glandular hyperplasia of the endo...

journal_title：Journal of reproductive immunology

authors： Murdoch AJ,Buckley CH,Fox H

更新日期：1982-02-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of pregnancy on the production of donor- and nondonor-specific anti-human leukocyte antigen antibodies (anti-HLA Abs) in organ allograft recipients. The study group included four pregnant kidney (RT) and four liver (LT) transplant recipients. The genotype of HLA class I ...

journal_title：Journal of reproductive immunology

authors： Cyganek A,Nowaczyk M,Sańko-Resmer J,Pietrzak B,Grzechocińska B,Pączek L,Międzybrodzki R,Wielgoś M

更新日期：2015-11-01 00:00:00

abstract：:The presence of a local immunosuppressive environment in the vicinity of the developing fetus has been suggested to explain survival of the semi-allogeneic fetus in a potentially hostile maternal immunologic environment. The presence of nonspecific suppressor cells in the uterus of pregnant mice has been well-document...

journal_title：Journal of reproductive immunology

authors： Kamel S,Wood GW

更新日期：1990-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS, endotoxin) is a component of the cell wall of gram-negative bacteria and a potent inducer of severe inflammatory reactions. In mice, systemically administered LPS induces fetal resorption and increases fetal mortality. However, effects of intrauterine LPS on fertility, fetal survival and devel...

journal_title：Journal of reproductive immunology

authors： Tuo W,Ott TL,Liu S,Bazer FW

更新日期：1999-01-01 00:00:00

abstract：:Pre-eclampsia (PE) remains the leading cause of pregnancy-associated mortality and morbidity, urging the need for a better understanding of its aetiology and pathophysiological progression. A key characteristic of PE is a systemic, exaggerated, inflammatory condition involving abnormal cytokine levels in serum, altere...

journal_title：Journal of reproductive immunology

authors： Al-ofi E,Coffelt SB,Anumba DO

更新日期：2014-06-01 00:00:00

abstract：:Despite immense effort, the development of vaccines effective at mucosal sites has proceeded at a faltering pace. Efforts concentrating on humoral immunity but neglecting cellular immunity may be misdirected by ignoring many viral mucosal pathogens. Improved understanding of the development and maintenance of lymphocy...

journal_title：Journal of reproductive immunology

authors： Gould DS,Ploegh HL,Schust DJ

更新日期：2001-10-01 00:00:00