Abstract:
:To analyze immunomodulating effects related to parity status, we studied trophoblast invasion grade, placental expression and systemic concentration of VEGF and its receptor Flt-1 in normal fertile (CBA/JxBALB/c) mice and abortion-prone (CBA/JxDBA/2) H-2(d)xH-2(k) mice. BALB/c or DBA/2 mated CBA/J females were, respectively, divided into the following groups: primiparous young (3.0+/-0.5 months old); primiparous old (8.5+/-0.5 months old) and multiparous old (8.5+/-0.5 months old, with 4 pregnancies). Immunohistochemical analysis of term placentae from both multiparous groups revealed various layers of invasive trophoblast tissue, identified as cytokeratin+/vimentin- cells, in contrast to the single layer detected in the placentae of primiparous animals, indicating that multiparity increases trophoblast invasion regardless of the success of the pregnancy outcome. Invasive trophoblast tissue from primiparous CBA/JxDBA/2 placentae showed diminished VEGF expression in comparison with the normal fertile group, while both multiparous groups demonstrated high expression of VEGF in the invasive trophoblast tissue. Placental expression of Flt-1 was similar in all groups. However, the primiparous CBA/JxBALB/c group showed the highest plasma concentration of sFlt-1 at term, while both multiparous groups demonstrated low circulating levels. No differences in circulating VEGF levels were observed among the groups. These results demonstrate an increase in trophoblast invasion tissue and expression of VEGF in the maternal-fetal interface in multiparous mice compared to primiparous mice. Moreover, the placenta appears to be able to regulate the circulating levels of VEGF by releasing sFlt-1.
journal_name
J Reprod Immunoljournal_title
Journal of reproductive immunologyauthors
Litwin S,Cortina ME,Barrientos GL,Prados MB,Roux ME,Miranda SEdoi
10.1016/j.jri.2010.03.004subject
Has Abstractpub_date
2010-06-01 00:00:00pages
161-7issue
2eissn
0165-0378issn
1872-7603pii
S0165-0378(10)00070-7journal_volume
85pub_type
杂志文章abstract::The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution a...
journal_title:Journal of reproductive immunology
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更新日期:2018-02-01 00:00:00
abstract::Human pre-implantation stage embryos cultured in vitro spontaneously secreted a factor capable of inducing histamine-release from human blood basophils. The embryo-derived histamine-releasing factor (EHRF) has been isolated from the culture medium by means of heparin-Sepharose affinity chromatography. The factor bound...
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
abstract::There is now evidence that the classical HLA class I molecule HLA-C is expressed on extravillous trophoblasts together with non-classical HLA-G molecules. Since clones of NK-cells are inhibited differently by supertypic epitopes associated with HLA-C and -B alleles we found it of interest to study HLA-C and -Bw polymo...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/s0165-0378(97)00073-9
更新日期:1997-12-15 00:00:00
abstract::During syngeneic pregnancy the numbers of 'spontaneously' occurring ('background') Ig-secreting cells were determined in the spleen, bone marrow (BM) and mesenteric lymph nodes (MLN) of BALB/c mice that were kept under germfree conditions and fed a low molecular weight synthetic diet (GF-CD), SPF BALB/c mice fed autoc...
journal_title:Journal of reproductive immunology
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更新日期:1986-11-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/s0165-0378(99)00064-9
更新日期:2000-05-01 00:00:00
abstract::A quantitative immunohistochemical study of IgA-containing plasma cells in the human uterine cervix has shown that the number of such cells increases during the late secretory phase of the menstrual cycle but decreases in the early secretory phase of the cycle, in pregnancy, in cystic glandular hyperplasia of the endo...
journal_title:Journal of reproductive immunology
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doi:10.1016/0165-0378(82)90020-1
更新日期:1982-02-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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journal_title:Journal of reproductive immunology
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更新日期:2001-10-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(79)90003-2
更新日期:1979-12-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(79)90013-5
更新日期:1979-07-01 00:00:00
abstract::Successful implantation is still the limiting step in IVF. We hypothesized that maternal plasma concentrations of certain cytokines at the time of embryo transfer could predict the likelihood of successful implantation and pregnancy. sIL-2R, IL-6, LIF, and MMP2 concentrations were measured in plasma from 160 IVF patie...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/j.jri.2012.02.005
更新日期:2012-06-01 00:00:00
abstract::The present review article compares NK cell subsets and cytokine patterns determined in the peripheral blood as well as results of functional in-vitro assays using peripheral NK cells of idiopathic recurrent miscarriage (iRM) patients with corresponding results obtained in female healthy controls and female renal tran...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章,评审
doi:10.1016/j.jri.2020.103098
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abstract::Development of a vaccine(s) based on sperm antigens represents a promising approach to contraception. The utility of an antigen in immunocontraception is contingent upon sperm/testis-specificity and its involvement in the fertilization process. Since, the sperm-zona pellucida (ZP) recognition and binding constitutes t...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/s0165-0378(01)00094-8
更新日期:2002-01-01 00:00:00
abstract::Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a grea...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(94)90013-2
更新日期:1994-08-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(91)90030-t
更新日期:1991-07-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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更新日期:1983-11-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(85)90008-7
更新日期:1985-12-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/j.jri.2016.03.005
更新日期:2016-06-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1980-12-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/j.jri.2003.10.004
更新日期:2004-06-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
abstract::The NOD mouse is a model for autoimmune diabetes that develops symptoms similar to Type I diabetes. The incidence of diabetes is greater in females but the degree of insulitis is comparable in both sexes. The purpose of this study was to assess the populations of lymphocytes and macrophages in the pancreas and spleen ...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/s0165-0378(96)00986-2
更新日期:1996-11-01 00:00:00
abstract::Published data on progeny sex ratio changes resulting from induction or administration of anti-male antibody in parental generation were compared by Fisher's independent test of significance. Sex ratio (males/total) depression is highly significant (P less than 0.001). Our large sample size data confirm this result; s...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章
doi:10.1016/0165-0378(85)90030-0
更新日期:1985-06-01 00:00:00
abstract::For many years, experience has been accumulated on embryo and gamete manipulation in livestock animals. The present work is a review of these techniques and their possible application in human embryology in specific cases. It is possible to manipulate gametes at different levels, producing paternal or maternal haploid...
journal_title:Journal of reproductive immunology
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00