当前位置： SCI文献检索 > JOURNAL OF REPRODUCTIVE IMMUNOLOGY期刊下所有文献 > Priming of peripheral monocytes with prolactin (PRL) sensitizes IFN-gamma-mediated indoleamine 2,3-dioxygenase (IDO) expression without affecting IFN-gamma signaling.

Priming of peripheral monocytes with prolactin (PRL) sensitizes IFN-gamma-mediated indoleamine 2,3-dioxygenase (IDO) expression without affecting IFN-gamma signaling.

Abstract：

:Prolactin (PRL) was originally identified by its ability to stimulate mammary development and lactation, and its essential roles other than lactation have recently been implicated in female reproduction. However, little is known about PRL-mediated events in pregnancy. The tryptophan catabolism enzyme indoleamine 2,3-dioxygenase (IDO) is interferon-gamma (IFN-gamma)-inducible and has recently become a focus for maternal-fetal tolerance for successful pregnancy. Based on recognition that PRL is one of the up-regulated hormones in pregnancy, in a previous study we have shown that PRL induces IDO expression in monocytes in cooperation with a suboptimal concentration of IFN-gamma. Here, we demonstrate that PRL sensitizes monocytes to induce IDO expression in response to low doses of IFN-gamma without affecting the typical IFN-gamma signaling events, such as STAT1 phosphorylation and IRF-1 induction. In addition, IDO induction in these cell cultures was observed only after 24 h pre-exposure to PRL. These results indicate a priming effect of PRL on monocytes that occurs before IFN-gamma signaling and increases their sensitivity to IFN-gamma for IDO induction, rather than a synergistic effect of PRL and IFN-gamma on IDO induction. These results offer new insights into the roles of PRL in female reproduction, as well as provide a better understanding as to how IDO expression is regulated and achieved in pregnancy.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Kawaguchi R,Shimokawa T,Umehara N,Nunomura S,Tanaka T,Ra C

doi

10.1016/j.jri.2007.08.003

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

117-25

issue

2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(07)00218-5

journal_volume

77

pub_type

杂志文章

相关文献

JOURNAL OF REPRODUCTIVE IMMUNOLOGY文献大全
  • Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors.

    abstract：:Few studies have assessed longitudinal changes in circulating cytokine levels during normal pregnancy. We have examined the natural history of maternal plasma cytokines from early- to mid-pregnancy in a large, longitudinal cohort. Multiplex flow cytometry was used to measure interleukin (IL)-2, IL-6, IL-12, tumor necr...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2007.06.051

    authors： Curry AE,Vogel I,Skogstrand K,Drews C,Schendel DE,Flanders WD,Hougaard DM,Thorsen P

    更新日期：2008-04-01 00:00:00

  • Suppressor cells in the human maternal-fetal relationship.

    abstract：:The mixed lymphocyte culture (MLC) of maternal and newborn (cord) cells is significantly weaker than that of father-newborn and control-newborn cultures. This hyporeactivity was found not to be due to an impaired function or tolerance of either the maternal or neonatal cells. We investigated the possibility that a spe...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(84)90041-x

    authors： Stankova J,Rola-Pleszczynski M

    更新日期：1984-01-01 00:00:00

  • Hormonal control of the secretory immune system of the human uterine cervix.

    abstract：:A quantitative immunohistochemical study of IgA-containing plasma cells in the human uterine cervix has shown that the number of such cells increases during the late secretory phase of the menstrual cycle but decreases in the early secretory phase of the cycle, in pregnancy, in cystic glandular hyperplasia of the endo...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(82)90020-1

    authors： Murdoch AJ,Buckley CH,Fox H

    更新日期：1982-02-01 00:00:00

  • Demonstration and characterization of HLA-DR positive cells in the stroma of human endometrium.

    abstract：:The proportion of stromal cells expressing DR antigens of the HLA system or reacting with an anti-macrophage antibody was studied by immunohistochemical methods in human proliferative, secretory and post-menopausal endometria. DR+ cells showed a rounded morphology with short expansions and represented 13-25% of the st...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(90)90015-x

    authors： Laguens G,Goñi JM Jr,Laguens M,Goñi JM,Laguens R

    更新日期：1990-09-01 00:00:00

  • Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model.

    abstract：:Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions. However, there are few reports on the relationship betw...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2019.103075

    authors： Wang J,Liu C,Que W,Fujino M,Tong G,Yan H,Li XK

    更新日期：2020-02-01 00:00:00

  • Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts.

    abstract：:Placental hypoxia following the immature remodeling of spiral arteries by extravillous cytotrophoblasts (CTs) is focused on the pathogenesis of pre-eclampsia. At the same time, the expression of human leukocyte antigen (HLA)-G is decreased at the protein and mRNA levels in the pre-eclamptic placenta. In view of the po...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2004.07.001

    authors： Nagamatsu T,Fujii T,Yamashita T,Miki A,Kanai T,Kusumi M,Osuga Y,Kozuma S,Taketani Y

    更新日期：2004-10-01 00:00:00

  • Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific.

    abstract：:Pharmacologic inhibition of indoleamine 2,3 dioxygenase (IDO) activity during murine pregnancy results in rejection of allogeneic fetuses by the maternal immune system. Here, we show that IDO expression is restricted to perinuclear regions of primary trophoblast giant cells (TGCs) of fetal origin at mid-gestation (E10...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2003.11.003

    authors： Baban B,Chandler P,McCool D,Marshall B,Munn DH,Mellor AL

    更新日期：2004-04-01 00:00:00

  • Autophagy regulation in preeclampsia: Pros and cons.

    abstract：:Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. This process has two main functions: producing energy and quality control of intracellular proteins. During early pregnancy, extravillous trophoblasts (EVTs) invade the uterine myometrium and migrate along t...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2017.08.006

    authors： Nakashima A,Aoki A,Kusabiraki T,Cheng SB,Sharma S,Saito S

    更新日期：2017-09-01 00:00:00

  • Reduction in uterine intra-epithelial lymphocytes during early gestation in pigs.

    abstract：:The numbers of intra-epithelial lymphocytes per 5 mm of uterine epithelium were counted in cyclic (n = 18) and pregnant (n = 18) gilts on days 10, 13, 16 and 19 postestrus. In cyclic animals these cells increased (P less than 0.01) from 26.4 +/- 1.1 per 5 mm at the mid-luteal phase (day 10) to 47.7 +/- 1.5 per 5 mm at...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(88)90034-4

    authors： King GJ

    更新日期：1988-10-01 00:00:00

  • MicroRNAs in pregnancy.

    abstract：:Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptiona...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2011.01.004

    authors： Morales Prieto DM,Markert UR

    更新日期：2011-03-01 00:00:00

  • Inhibition of penetration of canine zonae pellucidae by homologous spermatoza in vitro using monoclonal antibodies raised against porcine zonae.

    abstract：:Ten monoclonal antibodies (MAbs) raised against porcine zonae pellucidae (PZP) were checked for their reactivity against zonae of other species. Two (MAbs A6 and C10) out of six MAbs checked reacted with canine zonae as ascertained by indirect immunofluorescence. One of these cross-reactive MAbs (A6) inhibited the pen...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(88)90051-4

    authors： Bamezai AK,Mahi-Brown CA,Talwar GP

    更新日期：1988-06-01 00:00:00

  • Expression of Fas-ligand in first trimester and term human placental villi.

    abstract：:The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(99)00059-5

    authors： Hammer A,Dohr G

    更新日期：2000-03-01 00:00:00

  • Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women.

    abstract：:Although inflammation is associated with risk of gestational diabetes mellitus (GDM), little is known if there is an association between inflammation and GDM in African-American women, a group at higher risk for GDM complications. In the present study, we aimed to determine if selected inflammatory cytokines (i.e. TNF...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2016.03.005

    authors： Bossick AS,Peters RM,Burmeister C,Kakumanu N,Shill JE,Cassidy-Bushrow AE

    更新日期：2016-06-01 00:00:00

  • Characterization of decidual leukocyte populations in cynomolgus and vervet monkeys.

    abstract：:The objective of this study was the phenotypic and functional evaluation of decidual immune cells in the cynomolgus and vervet monkeys. Early pregnancy (days 36-42) deciduas were obtained by fetectomy for histological evaluation and decidual mononuclear leukocyte (MNL) isolation. While peripheral NK (pNK) cells in the...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2008.12.006

    authors： Dambaeva SV,Breburda EE,Durning M,Garthwaite MA,Golos TG

    更新日期：2009-06-01 00:00:00

  • Immunological studies of lactoferrin in human placentae.

    abstract：:Lactoferrin (LF) and transferrin (Trf) are glycoproteins with strong affinities for ferric ions. Human syncytiotrophoblastic membranes analyzed by enzyme linked immunosorbent assay (ELISA) and immunoblotting were negative with monoclonal and polyclonal antibodies to LF. Immunohistological studies of 35 normal placenta...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(93)90024-c

    authors： Thaler CJ,Labarrere CA,Hunt JS,McIntyre JA,Faulk WP

    更新日期：1993-01-01 00:00:00

  • The effect of human pregnancy serum on the synthesis and action of interleukin-1.

    abstract：:Supernatants from mixed lymphocyte reactions performed in the presence of pregnancy serum (PS) or normal human serum (NHS) were tested for interleukin-1 (IL-1) activity in a thymocyte assay. A lower response was obtained with PS-containing supernatants, suggesting that PS exerts its suppressive effect by inhibiting IL...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(88)90045-9

    authors： Garcia Domingo C,Moreno A,Palomino P

    更新日期：1988-06-01 00:00:00

  • Characterisation of the soluble fraction of human syncytiotrophoblast microvillous plasma membrane-associated proteins.

    abstract：:Syncytiotrophoblast microvillous plasma membrane (StMPM) preparations were obtained from human full-term placentae by previously published methods of cold saline extraction and phase centrifugation. Purity of these preparations was assessed by electron microscopy, enzyme analysis and hydroxyproline content. IgG, album...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(79)90013-5

    authors： Ogbimi AO,Johnson PM,Brown PJ,Fox H

    更新日期：1979-07-01 00:00:00

  • Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft?

    abstract：:Interactions between maternal immune cells and the placenta are of substantial interest since diseases of pregnancy, such as recurrent miscarriage, villitis of unknown etiology and preeclampsia may arise due to inadequate adaptation of the maternal immune system. During normal pregnancy trophoblast debris is shed from...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2012.03.488

    authors： Abumaree MH,Chamley LW,Badri M,El-Muzaini MF

    更新日期：2012-06-01 00:00:00

  • Antisperm autoantibody responses to vasectomy and vasovasostomy in Fischer and Lewis rats.

    abstract：:Antisperm autoantibodies were studied in Fischer and Lewis strains of rats after either vasectomy, vasectomy followed one month later by vasovasostomy, or sham operations. The time course of antibody response to sperm protein autoantigens was assayed by Western blot analysis of sera obtained at intervals up to 3 month...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(94)00904-l

    authors： Flickinger CJ,Howards SS,Bush LA,Baker LA,Herr JC

    更新日期：1995-02-01 00:00:00

  • In vitro production of human anti-sperm antibodies: effect of an oligoclonal antibody (F6) on sperm-egg interaction.

    abstract：:A method has been developed to establish lines of transformed lymphocytes able to produce in vitro the same anti-sperm antibodies as those naturally occurring in immuno-infertile individuals. We utilized lymphocytes from a male donor whose serum contained anti-sperm antibodies of the IgG class up to the dilution 1:10,...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(95)00939-i

    authors： Fusi FM,Besuschio F,De Santis L,Lorenzetti I,Ferrari A

    更新日期：1995-07-01 00:00:00

  • NK cell subsets in idiopathic recurrent miscarriage and renal transplant patients.

    abstract：:The present review article compares NK cell subsets and cytokine patterns determined in the peripheral blood as well as results of functional in-vitro assays using peripheral NK cells of idiopathic recurrent miscarriage (iRM) patients with corresponding results obtained in female healthy controls and female renal tran...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2020.103098

    authors： Toth B,Zhu L,Karakizlis H,Weimer R,Morath C,Opelz G,Kuon RJ,Daniel V

    更新日期：2020-04-01 00:00:00

  • The relationship between amniotic fluid macrophage colony-stimulating factor and fetal growth.

    abstract：:The aim of this study was to clarify whether amniotic fluid macrophage colony-stimulating factor (M-CSF) is related to placental development and fetal growth. Maternal serum and amniotic fluid M-CSF levels were analyzed in 22 pregnant women (seven intrauterine growth retardation (IUGR) complicated and 15 normal pregna...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(98)00002-3

    authors： Murakawa H,Mori S,Iida S,Atsumi Y,Suzuki M

    更新日期：1998-02-01 00:00:00

  • Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit.

    abstract：:The feasibility of producing epitope-specific antigens by mutation of the gene is demonstrated, the aim being to eliminate unwanted surface epitopes yet allowing the natural folding of the protein to maintain the desired epitope(s). The model protein is the beta subunit of human chorionic gonadotropin (hCG beta) which...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(96)00978-3

    authors： Jackson AM,Klonisch T,Lapthorn AJ,Berger P,Isaacs NW,Delves PJ,Lund T,Roitt IM

    更新日期：1996-08-01 00:00:00

  • Uterine stromal cell suppression of pIgR production by uterine epithelial cells in vitro: a mechanism for regulation of pIgR production.

    abstract：:Previous studies have shown that the polymeric Ig receptor (pIgR) is produced by rat uterine epithelial cells both in vivo and vitro. The expression of the pIgR is regulated by sex hormones and/or cytokines at mucosal sites, however the mechanism of regulation in the uterus is not clear. In these studies, co-culture o...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(97)00015-6

    authors： Richardson JM,Wira CR

    更新日期：1997-06-01 00:00:00

  • Expression of indoleamine 2,3-dioxygenase in the rhesus monkey and common marmoset.

    abstract：:Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan degradation along the kynurenine pathway, and is hypothesized to limit tryptophan availability at embryo implantation and prevent maternal T cell activation at the maternal-fetal interface. To determine if nonhuman primates ar...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2008.03.005

    authors： Drenzek JG,Breburda EE,Burleigh DW,Bondarenko GI,Grendell RL,Golos TG

    更新日期：2008-07-01 00:00:00

  • Effects of maternal anti H-Y antibodies on fetal gonadal development.

    abstract：:C57BL/6 inbred female mice preimmunized by serial injections of isogeneic male spleen cells were mated and the effects of the circulating anti H-Y antibodies on the fetal gonads and on their fertility were studied. Female mice receiving injections of saline formed one control group and those given female spleen cells ...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(81)90059-0

    authors： Rao CS,Vaidya RA,Ambani LM

    更新日期：1981-07-01 00:00:00

  • The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause.

    abstract：:A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(00)00087-5

    authors： Keller ET,Zhang J,Yao Z,Qi Y

    更新日期：2001-04-01 00:00:00

  • Antigen phenotype of cultured decidual stromal cells of human term decidua.

    abstract：:We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(99)00041-8

    authors： Oliver C,Cowdrey N,Abadía-Molina AC,Olivares EG

    更新日期：1999-11-01 00:00:00

  • Medium-dose intravenous immunoglobulin therapy for women with six or more recurrent miscarriages.

    abstract：:This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVI...

    journal_title：Journal of reproductive immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jri.2015.01.008

    authors： Yamada H,Deguchi M,Maesawa Y,Nakajima Y,Nishino Y,Tanimura K,Ebina Y

    更新日期：2015-06-01 00:00:00

  • Apical expression of an antigen common to rabbit yolk sac endoderm and kidney proximal tubule epithelium.

    abstract：:The tissue distribution, molecular weight, and biochemical nature of an antigen detected by a mouse monoclonal antibody designated 283D3 and raised against rabbit visceral yolk sac endodermal cells, has been investigated. The antigen is located on the luminal side of apical tubules and large sub-apical vesicles in rab...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(93)90046-k

    authors： Meads TJ,Wild AE

    更新日期：1993-04-01 00:00:00