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Antenatal inflammation and gestational diabetes mellitus risk among pregnant African-American women.

Abstract：

:Although inflammation is associated with risk of gestational diabetes mellitus (GDM), little is known if there is an association between inflammation and GDM in African-American women, a group at higher risk for GDM complications. In the present study, we aimed to determine if selected inflammatory cytokines (i.e. TNF-α, hs-CRP, IL-6, IL-10, IL-6/IL-10 ratio, IL-1β) measured in the 2nd trimester, were associated with GDM risk in 185 pregnant African-American women. GDM was defined as a physician-documented GDM diagnosis, a fasting glucose between 92 and 125mg/dl, or evidence of glucose intolerance (defined using the 3-h glucose tolerance test). A total of 18 women (9.7%) had GDM. After covariate adjustment, C-reactive protein, measured at a mean 21.2±3.7 weeks gestation, was statistically significantly associated with GDM development (P=0.025); for every one-unit increase in log-transformed C-reactive protein, the odds of GDM increased by 5.3. Results were similar using a principal component analysis approach. This study provides evidence that higher levels of 2nd trimester C-reactive protein is associated with increased risk of GDM in African-American women. Further research is needed to examine whether C-reactive protein may be a useful early-pregnancy screen for evaluating potential GDM risk in African-American women.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Bossick AS,Peters RM,Burmeister C,Kakumanu N,Shill JE,Cassidy-Bushrow AE

doi

10.1016/j.jri.2016.03.005

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1-5

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(16)30008-0

journal_volume

115

pub_type

杂志文章

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