Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation--a perspective.


:It is self-evident that infection and inflammation in the reproductive tract can inhibit male fertility, but the observation that fertility may also be compromised by systemic inflammation and disease is more difficult to explain. Recent studies implicating microbial pattern-recognition receptors, such as the Toll-like receptors (TLRs), as well as inflammatory cytokines and their signalling pathways, in testicular function have cast new light on this mysterious link between infection/inflammation and testicular dysfunction. It is increasingly evident that signalling pathways normally involved in controlling inflammation play fundamental roles in regulating Sertoli cell activity and responses to reproductive hormones, in addition to promoting immune responses within the testis. Many of the negative effects of inflammation on spermatogenesis may be attributed to elevated production of inflammation-related gene products within the circulation and the testis, which subsequently exert disruptive effects on spermatogenic cell development and survival, as well as the ability of the Sertoli cells to provide support for spermatogenesis. These interactions have important implications for testicular dysfunction and disease, and may eventually provide new opportunities for therapeutic interventions.


J Reprod Immunol


Hedger MP




Has Abstract


2011-03-01 00:00:00














  • Active or passive immunization in unexplained recurrent miscarriage.

    abstract::Controversy exists as to whether active immunotherapy with allogeneic lymphocyte transfusions (ALT) or passive immunotherapy with intravenous immunoglobulin (IvIg) improve the chance of live birth in women with unexplained recurrent miscarriages (RM). Meta-analyses of the placebo-controlled trials carried out as Cochr...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Christiansen OB,Nielsen HS,Pedersen B

    更新日期:2004-06-01 00:00:00

  • Intrauterine infusion of bacterial lipopolysaccharide (LPS) prior to mating has no adverse effect on fertility, fetal survival and fetal development.

    abstract::Lipopolysaccharide (LPS, endotoxin) is a component of the cell wall of gram-negative bacteria and a potent inducer of severe inflammatory reactions. In mice, systemically administered LPS induces fetal resorption and increases fetal mortality. However, effects of intrauterine LPS on fertility, fetal survival and devel...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Tuo W,Ott TL,Liu S,Bazer FW

    更新日期:1999-01-01 00:00:00

  • Identification and characterization of human acrosomal antigen defined by a monoclonal antibody with blocking effect on in vitro fertilization.

    abstract::A monoclonal anti-human sperm antibody (Mab 1A1) has been produced by fusion of myeloma cells with splenocytes from a BALB/c mouse immunized with in vitro capacitated human spermatozoa. Immunofluorescence studies with Mab 1A1 show that it recognizes an antigen(s) (Ag 1A1) which is located in the acrosome of human sper...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Dubova-Mihailova M,Mollova M,Ivanova M,Kehayov I,Kyurkchiev S

    更新日期:1991-04-01 00:00:00

  • Inhibition of natural killer cell activity by retroplacental sera as compared to peripheral sera. Lack of influence of immune complexes.

    abstract::A decrease of natural killer cell activity (NKCA) during human pregnancy might contribute to the acceptance of the allogeneic fetus by the maternal host. The inhibition of NKCA might be due to serum factors derived from the trophoblast. We focused especially on the role of immune complexes, as it has already been desc...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Struyf NJ,De Cleyn KM,Bridts CH,De Clerck LS,Buytaert PM,Stevens WJ

    更新日期:1989-12-01 00:00:00

  • Exposure to systemic and intrauterine inflammation leads to decreased pup survival via different placental mechanisms.

    abstract:PROBLEM:Exposure to systemic maternal inflammation (i.e., maternal sepsis, influenza, human immunodeficiency virus, or pyelonephritis) and intrauterine (IU) inflammation (i.e., chorioamnionitis or preterm labor) have been associated with adverse perinatal sequelae. Whether systemic and localized inflammation leading to...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Lee JY,Shin NE,Na Q,Dong J,Chudnovets A,Li S,Novak CM,McLane MW,Lei J,Burd I

    更新日期:2019-06-01 00:00:00

  • Risk factors for pregnancy failure in patients with antiphospholipid antibody positivity and prior pregnancy losses: A retrospective study.

    abstract:OBJECTIVES:To analyze the risk factors associated with pregnancy failure in patients with positive antiphospholipid antibodies (aPL) and prior pregnancy losses, with or without a diagnosis of antiphospholipid syndrome. METHODS:We retrospectively reviewed the medical records of all the pregnant patients with positive a...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Duan H,Li X,Liu C,Ge Y,Deng X

    更新日期:2020-09-01 00:00:00

  • GammadeltaTCR+ cells of the pregnant ovine uterus express variable T cell receptors and contain granulysin.

    abstract::Gammadelta T cells are a prominent granulated cell population in the ruminant pregnant uterus and both their number and granule size increase dramatically during pregnancy. Anchor-RT-PCR was used to assess TCRdelta gene usage by gammadelta T cells from the uterine epithelium of pregnant sheep. The TCRdelta genes obtai...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Fox A,Maddox JF,de Veer MJ,Meeusen EN

    更新日期:2010-01-01 00:00:00

  • Elution of anticardiolipin antibodies and their cofactor beta 2-glycoprotein 1 from the placentae of patients with a poor obstetric history.

    abstract::Anticardiolipin antibodies (aCL) were eluted from the placentae of four women with elevated serum levels of aCL, demonstrating that these antibodies are bound to affected placentae. Anticardiolipin antibodies bound to affected placentae were only of the IgG isotype and the level of aCL in placental eluates did not ref...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Chamley LW,Pattison NS,McKay EJ

    更新日期:1993-12-01 00:00:00

  • Platelet-activating factor and antiphospholipid antibodies in recurrent implantation failure.

    abstract::Recurrent implantation failure (RIF) refers to cases in which women have had the failure of the embryo implantation after several in vitro fertilization (IVF). The success rate for IVF depends on many different factors. Implantation is a complex step in a successful pregnancy. Antiphospholipid antibodies (aPLs) and pl...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Mahdian S,Pirjani R,Favaedi R,Movahedi M,Moini A,Shahhoseini M

    更新日期:2021-02-01 00:00:00

  • Determination of immunoglobulin classes and subclasses of sperm immobilizing antibodies in infertile women and the inhibitory effect of IgG4 subclass on the sperm immobilizing antibody activity.

    abstract::Immunoglobulin classes and subclasses of sperm immobilizing antibodies (SI-Abs) in the sera of sterile women were determined by the absorption of patients' sera with Staphylococcus aureus and immunoadsorbents bound with class or subclass-specific anti-human immunoglobulin antibodies. Among 18 patients' sera tested, 16...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Tsuji Y,Tatsumi T,Kameda K,Koyama K,Isojima S

    更新日期:1993-08-01 00:00:00

  • Immunological studies of lactoferrin in human placentae.

    abstract::Lactoferrin (LF) and transferrin (Trf) are glycoproteins with strong affinities for ferric ions. Human syncytiotrophoblastic membranes analyzed by enzyme linked immunosorbent assay (ELISA) and immunoblotting were negative with monoclonal and polyclonal antibodies to LF. Immunohistological studies of 35 normal placenta...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Thaler CJ,Labarrere CA,Hunt JS,McIntyre JA,Faulk WP

    更新日期:1993-01-01 00:00:00

  • Predictive biomarkers of preterm delivery in women with ongoing IVF pregnancies.

    abstract::In vitro fertilization (IVF) pregnancies potentially have a higher rate of preterm delivery (PTD) than do spontaneously conceived gestations, and differences persist following adjustment for multiple gestation, maternal age, and parity. The reasons for this increased susceptibility to PTD remain incompletely elucidate...

    journal_title:Journal of reproductive immunology

    pub_type: 临床试验,杂志文章


    authors: Kanninen TT,Sisti G,Ramer I,Goldschlag D,Witkin SS,Spandorfer SD

    更新日期:2015-11-01 00:00:00

  • Fc receptor blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.

    abstract::In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc receptor blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) a...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kuhn U,Blasczyk R,Hojnacki B,Vögeler U,Luboldt W,Passarge E,Fischer WM,Grosse-Wilde H

    更新日期:1991-07-01 00:00:00

  • Uterine stromal cell suppression of pIgR production by uterine epithelial cells in vitro: a mechanism for regulation of pIgR production.

    abstract::Previous studies have shown that the polymeric Ig receptor (pIgR) is produced by rat uterine epithelial cells both in vivo and vitro. The expression of the pIgR is regulated by sex hormones and/or cytokines at mucosal sites, however the mechanism of regulation in the uterus is not clear. In these studies, co-culture o...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Richardson JM,Wira CR

    更新日期:1997-06-01 00:00:00

  • Anti-male (anti-H-Y) male treatment influences progeny sex ratio.

    abstract::Published data on progeny sex ratio changes resulting from induction or administration of anti-male antibody in parental generation were compared by Fisher's independent test of significance. Sex ratio (males/total) depression is highly significant (P less than 0.001). Our large sample size data confirm this result; s...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Pechan P

    更新日期:1985-06-01 00:00:00

  • Gene fusion of molecular adjuvant C3d to hCGbeta enhances the anti-hCGbeta antibody response in DNA immunization.

    abstract:OBJECTIVE:To express the hCGbeta-C3d3 fusion protein in a CHO cell continual expression system to investigate further the adjuvant effects of C3d on contraceptive vaccination. METHOD:We constructed a plasmid pcDNA3-hCGbeta-C3d3 which contains three copies of murine C3d cDNA and the hCGbeta gene by cloning the chimeric...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Li DJ,Wang HM,Li L,Zhao XR,Wang MY,Zhu Y,Meng Y,Yuan MM

    更新日期:2003-12-01 00:00:00

  • Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate.

    abstract::Effector cells associated with an aborting fetus appear to be both thymus derived (T) and natural killer (NK) cells. In order to test the hypothesis that NK cells are a major effector mediating early spontaneous abortion (less than day 8-10), CBA female mice mated by DBA/2 males were treated with either polyinosinic/c...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: de Fougerolles AR,Baines MG

    更新日期:1987-06-01 00:00:00

  • The effect of pregnancy on humoral rejection in patients after vascularized organ transplantation.

    abstract::The aim of the study was to evaluate the effect of pregnancy on the production of donor- and nondonor-specific anti-human leukocyte antigen antibodies (anti-HLA Abs) in organ allograft recipients. The study group included four pregnant kidney (RT) and four liver (LT) transplant recipients. The genotype of HLA class I ...

    journal_title:Journal of reproductive immunology

    pub_type: 临床试验,杂志文章


    authors: Cyganek A,Nowaczyk M,Sańko-Resmer J,Pietrzak B,Grzechocińska B,Pączek L,Międzybrodzki R,Wielgoś M

    更新日期:2015-11-01 00:00:00

  • Prednisone improves pregnancy outcome in repeated implantation failure by enhance regulatory T cells bias.

    abstract:OBJECTIVE:Repeated implantation failure (RIF) has been shown related to maternal immune imbalance. Many studies suggested that prednisone promoted the Th17/Treg balance shift to the direction of immune tolerance. Our study aimed to evaluate the role of prednisone in Th17/Treg balance and pregnancy outcome in RIF patien...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Huang Q,Wu H,Li M,Yang Y,Fu X

    更新日期:2021-02-01 00:00:00

  • Signal transduction pathways in human spermatozoa.

    abstract::Following ejaculation, sperm functions are regulated by interactions with the environment found in the female genital tract. Here spermatozoa become 'capacitated' (i.e. they acquire the capability of completing the acrosome reaction and successfully fertilizing the egg), through a series of surface and intracellular t...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Baldi E,Luconi M,Bonaccorsi L,Forti G

    更新日期:2002-01-01 00:00:00

  • Decidual stromal cell-derived IL-33 contributes to Th2 bias and inhibits decidual NK cell cytotoxicity through NF-κB signaling in human early pregnancy.

    abstract::Decidual stromal cells (DSCs) are an important component of decidual tissues where they are in strict proximity with immune cells. Although previous research has indicated that DSCs participate in the regulation of immune cells during pregnancy, the crosstalk between DSCs and decidual NK cells (dNKs) has not been full...

    journal_title:Journal of reproductive immunology

    pub_type: 临床试验,杂志文章


    authors: Hu WT,Huang LL,Li MQ,Jin LP,Li DJ,Zhu XY

    更新日期:2015-06-01 00:00:00

  • Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery.

    abstract:INTRODUCTION:Mice disrupted for the interleukin (IL)-18 gene appear more disposed to preterm delivery (PTD) induced by inflammation. A synergy between IL-18 and IL-12 has been suggested. The objective of this study was to investigate a possible relation between human maternal serum levels of IL-18, IL-12 and spontaneou...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Ekelund CK,Vogel I,Skogstrand K,Thorsen P,Hougaard DM,Langhoff-Roos J,Jacobsson B

    更新日期:2008-04-01 00:00:00

  • Reflections upon immunological mechanisms involved in fertility, pregnancy and parasite infections.

    abstract::During a pregnancy, the mother accepts her semi-allogeneic fetus with no signs of immunological rejection. Therefore, some modulation of the maternal immune system must occur. Similarly, changes in the host's immune system occurs during infections with parasites. In a study conducted in an endemic area in Bolivia, it ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Persson G,Ekmann JR,Hviid TVF

    更新日期:2019-11-01 00:00:00

  • Suppression of fertility in male mice by immunization against LH receptor.

    abstract::We have investigated the potential contraceptive effects of immunization against the luteinizing hormone (LH) receptor in male mice at the prepubertal stage. Two N-terminal fragments of the porcine LH receptor encoding amino acids 1-297 and 1-370 were produced in large quantities through the Baculovirus insect cell sy...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Remy JJ,Bozon V,Couture L,Goxe B,Salesse R,Garnier J

    更新日期:1993-09-01 00:00:00

  • The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause.

    abstract::A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Keller ET,Zhang J,Yao Z,Qi Y

    更新日期:2001-04-01 00:00:00

  • Suppressor cells in the human maternal-fetal relationship.

    abstract::The mixed lymphocyte culture (MLC) of maternal and newborn (cord) cells is significantly weaker than that of father-newborn and control-newborn cultures. This hyporeactivity was found not to be due to an impaired function or tolerance of either the maternal or neonatal cells. We investigated the possibility that a spe...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Stankova J,Rola-Pleszczynski M

    更新日期:1984-01-01 00:00:00

  • Multiparity increases trophoblast invasion and vascular endothelial growth factor expression at the maternal-fetal interface in mice.

    abstract::To analyze immunomodulating effects related to parity status, we studied trophoblast invasion grade, placental expression and systemic concentration of VEGF and its receptor Flt-1 in normal fertile (CBA/JxBALB/c) mice and abortion-prone (CBA/JxDBA/2) H-2(d)xH-2(k) mice. BALB/c or DBA/2 mated CBA/J females were, respec...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Litwin S,Cortina ME,Barrientos GL,Prados MB,Roux ME,Miranda SE

    更新日期:2010-06-01 00:00:00

  • Involvement of trophoblast in embryo implantation: regulation by paracrine factors.

    abstract::In order to investigate the regulatory role of only one endometrial cell type on trophoblastic invasion, we explored the effects of culture medium conditioned by in vitro decidualised stromal cells (DCM) and of insulin-like growth factor binding protein-1 (IGFBP-1, the main secretory product of decidual cells) on the ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Bischof P,Meisser A,Campana A

    更新日期:1998-08-01 00:00:00

  • Transfer of susceptibility to experimental autoimmune orchitis from responder to non-responder substrains of BALB/c mice.

    abstract::Substrains of BALB/c mice differ in their susceptibility to experimental autoimmune orchitis (EAO), with BALB/cJ representative of the non-responders and BALB/cBy representative of the responders. We examined whether the susceptibility of these two substrains could be altered by reciprocal adoptive transfer of lymphoi...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Mahi-Brown CA,Tung KS

    更新日期:1990-10-01 00:00:00

  • Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion.

    abstract::Mammalian pregnancy is a complex phenomenon allowing the maternal immune system to support its allogeneic fetus. Physiological pathways protecting the fetus from rejection are thought to be comparable with those leading to allograft acceptance. Heme oxygenase (HO)-1 is known to protect locally against rejection in tra...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Zenclussen ML,Anegon I,Bertoja AZ,Chauveau C,Vogt K,Gerlof K,Sollwedel A,Volk HD,Ritter T,Zenclussen AC

    更新日期:2006-02-01 00:00:00