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Local and systemic levels of cytokines and danger signals in endometriosis-affected women.

Abstract：

:Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis. However, we found no direct evidence for a significant up-regulation of danger signals in endometriosis, irrespective of the severity of the disease.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Jaeger-Lansky A,Schmidthaler K,Kuessel L,Gstöttner M,Waidhofer-Söllner P,Zlabinger GJ,Wenzl R,Eiwegger T

doi

10.1016/j.jri.2018.07.006

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

7-10

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(18)30021-4

journal_volume

130

pub_type

杂志文章

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