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Evidence for the expression of granulocyte-macrophage colony-stimulating factor receptors by human first trimester extravillous trophoblast and its response to this cytokine.

Abstract：

:The present study has demonstrated that human extravillous trophoblast cells isolated from first trimester placentae can bind granulocyte-macrophage colony-stimulating factor (GM-CSF). We have used a technique which incorporates a phycoerythrin (PE)-conjugated GM-CSF in association with a monoclonal antibody against trophoblast (BC-1) in single and double flow cytometric analysis. Trophoblast cells are also observed to show increased DNA synthesis in response to GM-CSF as assayed by [3H]thymidine incorporation and proliferative activity as demonstrated by double immunocytochemical staining of cells with a trophoblast cytokeratin marker (PKK1) and for the nuclear proliferation antigen (Ki-67). These findings provide evidence that human extravillous trophoblast expresses receptors for GM-CSF and responds to this cytokine.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Loke YW,King A,Gardner L,Carter NP

doi

10.1016/0165-0378(92)90004-n

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

33-45

issue

1

eissn

0165-0378

issn

1872-7603

pii

0165-0378(92)90004-N

journal_volume

22

pub_type

杂志文章

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