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Sperm/DNA interaction: integration of foreign DNA sequences in the mouse sperm genome.

Abstract：

:Foreign DNA is spontaneously taken up by mouse epididymal sperm cells and is further internalized into nuclei. The interaction and/or internalization of the exogenous DNA triggers the activation of sperm endogenous nucleases which mediate rearrangements of the internalized DNA. Foreign DNA sequences are found to be tightly bound to the sperm nuclear scaffold, and to undergo a recombination process with the sperm chromosomal DNA. Sequence analysis of randomly selected clones from a library of sperm genomic DNA transformed with pSV2CAT plasmid showed that foreign sequences were integrated in a unique site of the sperm genome. Preliminary results suggest that the integration process is mediated by a retrotranscription step.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Magnano AR,Giordano R,Moscufo N,Baccetti B,Spadafora C

doi

10.1016/s0165-0378(98)00058-8

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

187-96

issue

1-2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(98)00058-8

journal_volume

41

pub_type

杂志文章,评审

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