Peptide presentation and NK inhibition by HLA-G.

abstract：:There is now evidence that the classical HLA class I molecule HLA-C is expressed on extravillous trophoblasts together with non-classical HLA-G molecules. Since clones of NK-cells are inhibited differently by supertypic epitopes associated with HLA-C and -B alleles we found it of interest to study HLA-C and -Bw polymo...

journal_title：Journal of reproductive immunology

authors： Christiansen OB,Mohapeloa HP,Steffensen R,Jersild C

更新日期：1997-12-15 00:00:00

abstract：:The feasibility of using the rhesus monkey as a non-human primate model for testing the efficacy of a contraceptive vaccine based on FA-1 antigen was evaluated. Affinity-purified anti-FA-1 polyclonal antibodies (Fab' fragments) and anti-FA-1 monoclonal antibody were used as probes in these studies. Anti-FA-1 antibodie...

journal_title：Journal of reproductive immunology

authors： Naz RK,Wolf DP

更新日期：1994-10-01 00:00:00

abstract：:We have previously shown that progesterone-treated lymphocytes of healthy pregnant women can produce a 34 kDa protein, progesterone-induced blocking factor (PIBF) capable of blocking lymphocyte function in vitro. Lymphocytes of women with idiopathic threatened pre-term delivery failed to produce this factor. On the as...

journal_title：Journal of reproductive immunology

authors： Szekeres-Bartho J,Varga P,Pejtsik B

更新日期：1989-09-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) were identified in samples of first trimester and term placentas by immunocytochemistry using two sets of polyclonal antibodies to recombinant IL-1. All samples contained the two species of IL-1, which predominated in different types of cells: IL-1 al...

journal_title：Journal of reproductive immunology

authors： Hu XL,Yang Y,Hunt JS

更新日期：1992-10-01 00:00:00

abstract：:It is self-evident that infection and inflammation in the reproductive tract can inhibit male fertility, but the observation that fertility may also be compromised by systemic inflammation and disease is more difficult to explain. Recent studies implicating microbial pattern-recognition receptors, such as the Toll-lik...

journal_title：Journal of reproductive immunology

authors： Hedger MP

更新日期：2011-03-01 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains ...

journal_title：Journal of reproductive immunology

authors： Chan T,Barra NG,Lee AJ,Ashkar AA

更新日期：2011-03-01 00:00:00

abstract：:Progesterone and glucocorticoids share important anti-inflammatory and immunosuppressive properties. Both hormones have potent anti-proliferative effects in MLR, mitogen activation and cytotoxic T-cell generation. We investigated the cellular target of this in vitro anti-proliferative activity by comparing the effects...

journal_title：Journal of reproductive immunology

authors： Stites DP,Bugbee S,Siiteri PK

更新日期：1983-07-01 00:00:00

abstract：:The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

journal_title：Journal of reproductive immunology

authors： Hammer A,Dohr G

更新日期：2000-03-01 00:00:00

abstract：:Antisera to Mason-Pfizer or Baboon Endogenous Virus possessed complement-dependent cytotoxicity for cell lines chronically infected with these viruses, with some degree of cross-reaction. When appropriately absorbed with virus-free cells, the antisera were not cytotoxic for lymphocytes of adult males but lysed lymphoc...

journal_title：Journal of reproductive immunology

authors： Thiry L,Sprecher-Goldberger S,Hard RC,Bossens M,Neuray F

更新日期：1981-03-01 00:00:00

abstract：:Lymphohematopoietic cytokines play a significant role in many biological mechanisms including a number of reproductive processes such as ovulation, implantation, placentation, cervical dilation and parturition. Recent experiments have suggested that cytokines play a crucial role in the mechanisms of preterm labor and ...

journal_title：Journal of reproductive immunology

authors： Saji F,Samejima Y,Kamiura S,Sawai K,Shimoya K,Kimura T

更新日期：2000-07-01 00:00:00

abstract：:Recurrent spontaneous abortion (RSA) can be attributed to multiple factors, and abnormal invasion and apoptosis of trophoblast cells have attracted extensive attention. Our study aimed to investigate the expression of PTEN and miRNAs with potential regulatory relationships in the placental villi of RSA patients. Ninet...

journal_title：Journal of reproductive immunology

authors： Tian S,Yu J,Zhang Y,Bian Y,Ma J,Yan J

更新日期：2020-08-01 00:00:00

abstract：:Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptiona...

journal_title：Journal of reproductive immunology

authors： Morales Prieto DM,Markert UR

更新日期：2011-03-01 00:00:00

abstract：:A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/...

journal_title：Journal of reproductive immunology

authors： Keller ET,Zhang J,Yao Z,Qi Y

更新日期：2001-04-01 00:00:00

abstract：:We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...

journal_title：Journal of reproductive immunology

authors： Oliver C,Cowdrey N,Abadía-Molina AC,Olivares EG

更新日期：1999-11-01 00:00:00

abstract：:Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been ...

journal_title：Journal of reproductive immunology

authors： Blois SM,Conrad ML,Freitag N,Barrientos G

更新日期：2015-04-01 00:00:00

abstract：:The detrimental consequences of obesity on female fertility are well known, but the functional changes that occur in the ovary in response to elevated BMI are not clear. Obesity induces multiple components of a systemic inflammatory state that is a key pathway by which it initiates tissue dysfunction in adipose, liver...

journal_title：Journal of reproductive immunology

authors： Gonzalez MB,Lane M,Knight EJ,Robker RL

更新日期：2018-11-01 00:00:00

abstract：:Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the pr...

journal_title：Journal of reproductive immunology

authors： Schnabel A,Blois SM,Meint P,Freitag N,Ernst W,Barrientos G,Conrad ML,Rose M,Seelbach-Göbel B

更新日期：2016-04-01 00:00:00

abstract：:Several members of the immunoglobulin-like transcript (ILT), also called leukocyte immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon binding of these ligands. The ligands for ILT2 (LIR1/CD...

journal_title：Journal of reproductive immunology

authors： Petroff MG,Sedlmayr P,Azzola D,Hunt JS

更新日期：2002-07-01 00:00:00

abstract：:Therapeutic interventions and public education are reducing pediatric AIDS cases in developed countries, but the number of HIV-infected women and children is still a major global concern. The finding that human sperm-associated HIV can be transmitted to oocytes following in vitro fertilization provides a novel viewpoi...

journal_title：Journal of reproductive immunology

authors： Douglas GC,Fazely F,Hu JJ

更新日期：1998-12-01 00:00:00

abstract：:A decrease of natural killer cell activity (NKCA) during human pregnancy might contribute to the acceptance of the allogeneic fetus by the maternal host. The inhibition of NKCA might be due to serum factors derived from the trophoblast. We focused especially on the role of immune complexes, as it has already been desc...

journal_title：Journal of reproductive immunology

authors： Struyf NJ,De Cleyn KM,Bridts CH,De Clerck LS,Buytaert PM,Stevens WJ

更新日期：1989-12-01 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by ...

journal_title：Journal of reproductive immunology

authors： Parr MB,Parr EL

更新日期：1997-11-30 00:00:00

abstract：:Following ejaculation, sperm functions are regulated by interactions with the environment found in the female genital tract. Here spermatozoa become 'capacitated' (i.e. they acquire the capability of completing the acrosome reaction and successfully fertilizing the egg), through a series of surface and intracellular t...

journal_title：Journal of reproductive immunology

authors： Baldi E,Luconi M,Bonaccorsi L,Forti G

更新日期：2002-01-01 00:00:00

abstract：:Natural killer (NK) cells comprise of ∼70% of the immune cell population in the maternal decidua and ∼15% of the mononuclear cells in the peripheral blood. The decidual NK cells capable of producing high levels of cytokines are functionally distinct from the peripheral NK cells that exhibit high cytotoxicity. The numb...

journal_title：Journal of reproductive immunology

authors： Dixit A,Karande AA

更新日期：2020-02-01 00:00:00

abstract：:The levels of rabbit alpha-foetoprotein (RAFP) in foetal serum, neonatal serum and amniotic fluid during gestation have been evaluated by quantitative radial immunodiffusion. RAFP attained its peak concentration on the 24th day of pregnancy in foetal serum, while in amniotic fluid peaks were observed on ;the 14th and...

journal_title：Journal of reproductive immunology

authors： Clarke LE

更新日期：1980-11-01 00:00:00

abstract：:Currently, different approaches are used to select oocytes for in vitro fertilization (IVF) procedures, but they do not assure a significant association with the pregnancy outcome. Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker of elevated implantation rat...

journal_title：Journal of reproductive immunology

authors： Rizzo R,Fuzzi B,Stignani M,Criscuoli L,Melchiorri L,Dabizzi S,Campioni D,Lanza F,Marzola A,Branconi F,Noci I,Baricordi OR

更新日期：2007-06-01 00:00:00

abstract：:We have previously shown that DBA/1 mice immunized with heterologous type II collagen showed remission of the subsequent collagen-induced arthritis (CIA) when pregnant, but experienced exacerbation postpartum. Measurement of anticollagen antibody (aCa) responses by ELISA in primiparous mice immunized at day 1 of pregn...

journal_title：Journal of reproductive immunology

authors： Whyte A,Hasan Z,Rutter F

更新日期：1988-08-01 00:00:00

abstract：:The present review article compares NK cell subsets and cytokine patterns determined in the peripheral blood as well as results of functional in-vitro assays using peripheral NK cells of idiopathic recurrent miscarriage (iRM) patients with corresponding results obtained in female healthy controls and female renal tran...

journal_title：Journal of reproductive immunology

authors： Toth B,Zhu L,Karakizlis H,Weimer R,Morath C,Opelz G,Kuon RJ,Daniel V

更新日期：2020-04-01 00:00:00

abstract：:The presence of a local immunosuppressive environment in the vicinity of the developing fetus has been suggested to explain survival of the semi-allogeneic fetus in a potentially hostile maternal immunologic environment. The presence of nonspecific suppressor cells in the uterus of pregnant mice has been well-document...

journal_title：Journal of reproductive immunology

authors： Kamel S,Wood GW

更新日期：1990-06-01 00:00:00

abstract：:The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution a...

journal_title：Journal of reproductive immunology

authors： Ponte R,Dupuy FP,Brimo F,Mehraj V,Brassard P,Belanger M,Yurchenko E,Jenabian MA,Bernard NF,Routy JP,ORCHID study group.

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare serum levels of leptin in women with unexplained infertility with fertile subjects. MATERIAL AND METHOD:Serum leptin levels of 27 infertile and 30 fertile women on day 3 of the menstrual cycle were assessed and compared in this prospective age and body mass index (BMI)...

journal_title：Journal of reproductive immunology

authors： Demir B,Guven S,Guven ES,Atamer Y,Gunalp GS,Gul T

更新日期：2007-10-01 00:00:00