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Medium-dose intravenous immunoglobulin therapy for women with six or more recurrent miscarriages.

Abstract：

:This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVIg therapy (20 g daily, for three days) during early gestation. NK cell activity in the peripheral blood decreased to 12% one week after therapy compared with before therapy (median, 22%, P < 0.001) and the percentage of monocytes increased from 5.2% to 7.5% (P < 0.005). Four pregnancies ended in live births of healthy neonates, whereas the other ten pregnancies ended in miscarriages. Excluding one miscarriage with a chromosomal abnormality, the live birth rate was 30.8% (4/13). The rate of reduction of NK cell activity in the success group (-58.8%) tended to be greater than that in the failure group (-14.8%, P = 0.057).

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Yamada H,Deguchi M,Maesawa Y,Nakajima Y,Nishino Y,Tanimura K,Ebina Y

doi

10.1016/j.jri.2015.01.008

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

48-51

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(15)00026-1

journal_volume

109

pub_type

临床试验,杂志文章

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