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Prostaglandin-E2 released by pre-implantation human conceptuses.

Abstract：

:This work investigates the production of prostaglandin E2 (PGE2), a well known modulator for the suppression of immune cells, by pre-implantation human conceptuses from the 4-cell stage to the hatched blastocyst and by cumulus oophorus cells, these being obtained from an IVF/ET program. Cumulus cell complexes cultured for 48 h produced considerable amounts of PGE2, necessitating complete removal of their influence on the conceptus cultures. All stages of the human conceptus studied produced PGE2 during 48-h cultures, the greatest amounts from late blastocysts, and from those cultured in media containing bovine serum albumin rather than human donor serum. Indomethacin-treated control blastocysts confirmed the synthesis and release from the human conceptuses. The production of PGF2a from human blastocysts could not be demonstrated.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Holmes PV,Sjögren A,Hamberger L

doi

10.1016/0165-0378(90)90041-4

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

79-86

issue

1

eissn

0165-0378

issn

1872-7603

pii

0165-0378(90)90041-4

journal_volume

17

pub_type

杂志文章

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