Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.

Abstract:

:Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains complex and involves a balance between innate signaling pathways and the adaptive immune response. Primary infection with HSV-2 induces toll-like receptor (TLR)-mediated Type I interferon (IFN) production, which establishes an antiviral state and activates multiple cell types, including natural killer cells and plasmacytoid dendritic cells. This innate response is not only crucial for controlling initial infection, but also for priming adaptive immune responses as well. Both humoral and cellular responses encompass adaptive immunity, although the former has been shown to be dispensable in response to HSV-2. Recently, numerous studies have attributed IFNγ producing CD4(+) T cells to be the key effector molecule responsible for clearing infection. It remains unclear whether regulatory T (Treg) cells are a source of aid or hindrance in the clearance of disease. Collectively, this review highlights the balance between innate and adaptive effector responses that contribute to the control and clearance of HSV-2 infection.

journal_name

J Reprod Immunol

authors

Chan T,Barra NG,Lee AJ,Ashkar AA

doi

10.1016/j.jri.2011.01.001

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

210-8

issue

2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(11)00007-6

journal_volume

88

pub_type

杂志文章,评审
  • Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts.

    abstract::Placental hypoxia following the immature remodeling of spiral arteries by extravillous cytotrophoblasts (CTs) is focused on the pathogenesis of pre-eclampsia. At the same time, the expression of human leukocyte antigen (HLA)-G is decreased at the protein and mRNA levels in the pre-eclamptic placenta. In view of the po...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2004.07.001

    authors: Nagamatsu T,Fujii T,Yamashita T,Miki A,Kanai T,Kusumi M,Osuga Y,Kozuma S,Taketani Y

    更新日期:2004-10-01 00:00:00

  • Early increase in graft-versus-host reactivity during pregnancy in the mouse.

    abstract::Alloreactive T levels of para-aortic lymph nodes (PALN) and spleen were determined on different days of pregnancy in BALB/c females by local and systemic graft-versus-host (GvH) assays. A significant increase in GvH reactivity was registered early in both allogeneic and syngeneic matings, operating not only towards pa...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(85)90036-1

    authors: Piazzón I,Matusevich M,Déroche A,Nepomnaschy I,Pasqualini CD

    更新日期:1985-11-01 00:00:00

  • Peripheral K cells in normal human pregnancy: decrease during pregnancy and increase after delivery.

    abstract::Peripheral blood levels of K cells were measured in normal pregnant and post-partum women by a plaque-forming cell technique that detects K cells on the basis of their activity of antibody-dependent cell-mediated cytotoxicity (ADCC). Peripheral K cells decreased throughout normal pregnancy (n = 46; 7.8 +/- 3.4%, P les...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(89)90042-9

    authors: Asari S,Iwatani Y,Amino N,Tanizawa O,Miyai K

    更新日期:1989-03-01 00:00:00

  • Immunological regulation of trophoblast invasion.

    abstract::In investigating the immunological regulation of trophoblast invasion, emphasis is frequently placed on the constitution of the implantation site and its specific characteristics. However trophoblast cells are able of invading into not only the uterine tissue, but in the case of ectopic pregnancies also invade into ot...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jri.2011.05.001

    authors: Hammer A

    更新日期:2011-06-01 00:00:00

  • Suppressor cells in the human maternal-fetal relationship.

    abstract::The mixed lymphocyte culture (MLC) of maternal and newborn (cord) cells is significantly weaker than that of father-newborn and control-newborn cultures. This hyporeactivity was found not to be due to an impaired function or tolerance of either the maternal or neonatal cells. We investigated the possibility that a spe...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(84)90041-x

    authors: Stankova J,Rola-Pleszczynski M

    更新日期:1984-01-01 00:00:00

  • Pregnancy and multiple sclerosis: feto-maternal immune cross talk and its implications for disease activity.

    abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system of presumed autoimmune origin. Intriguingly, pregnancy in female MS patients is associated with a substantial decrease in relapse rate. However, post-partum the relapse rate increases in a rebounding fashion above the rate ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jri.2012.10.005

    authors: Patas K,Engler JB,Friese MA,Gold SM

    更新日期:2013-03-01 00:00:00

  • A search for antibodies in term maternal sera to solubilized syncytiotrophoblast surface components. A passive haemagglutination assay yields negative evidence.

    abstract::Using a passive haemagglutination assay, agglutinins against trophoblast components were detected in term maternal sera at titres above those of non-pregnant control sera. These agglutinin titres were independent of the family relationship between individual sera and trophoblast samples. They were unaffected by adsorp...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(86)90031-8

    authors: Nickson DA,Sutcliffe RG

    更新日期:1986-12-01 00:00:00

  • Lymphocyte subsets in patients with oestrogen deficiency.

    abstract::We have previously shown that in patients with idiopathic premature ovarian failure there were significant changes in lymphocyte subsets. To test our hypothesis that these changes were due to oestrogen deficiency we studied lymphocyte subsets in patients with oestrogen deficiency due to other causes. Blood was taken f...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(91)90025-l

    authors: Ho PC,Tang GW,Lawton JW

    更新日期:1991-05-01 00:00:00

  • Overexpression of PTEN regulated by miR-19b and miR-494 in the villous of recurrent spontaneous abortion patients.

    abstract::Recurrent spontaneous abortion (RSA) can be attributed to multiple factors, and abnormal invasion and apoptosis of trophoblast cells have attracted extensive attention. Our study aimed to investigate the expression of PTEN and miRNAs with potential regulatory relationships in the placental villi of RSA patients. Ninet...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2020.103133

    authors: Tian S,Yu J,Zhang Y,Bian Y,Ma J,Yan J

    更新日期:2020-08-01 00:00:00

  • Expression of Fas-ligand in first trimester and term human placental villi.

    abstract::The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/s0165-0378(99)00059-5

    authors: Hammer A,Dohr G

    更新日期:2000-03-01 00:00:00

  • Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole.

    abstract:BACKGROUND:Elongation factor Tu GTP binding domain containing 2 (EFTUD2) is an alternative splicing factor that modulates cell differentiation and activation processes. EFTUD2 is known to modulate immune responses and mutation of the EFTUD2-gene lead to fetal malformation. Little is known about its expression and role ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2020.103149

    authors: Löb S,Vattai A,Kuhn C,Schmoeckel E,Mahner S,Wöckel A,Kolben T,Szekeres-Bartho J,Jeschke U,Vilsmaier T

    更新日期:2020-08-01 00:00:00

  • Th1/Th2 balance in preeclampsia.

    abstract::The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system all...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-0378(03)00045-7

    authors: Saito S,Sakai M

    更新日期:2003-08-01 00:00:00

  • Immunocytochemical localization of antibody during placental transmission of immunity in rats.

    abstract::Autologous anti-horseradish peroxidase antibody has been localized in pregnant rats at various levels through placental membranes en passage to fetal circulation. The antibody was complexed in situ with the antigen and the resulting complex was made visible electron microscopically by immunohistochemical techniques. V...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(85)90057-9

    authors: Jollie WP

    更新日期:1985-05-01 00:00:00

  • Delineation of epitopes on porcine zona pellucida relevant for binding of sperm to oocyte using monoclonal antibodies.

    abstract::Seven monoclonal antibodies (MAs) generated against porcine zona pellucida glycoprotein, ZP3 (comprising both ZP3 alpha and ZP3 beta) were characterized for their specificities to ZP3 alpha (MA 7 and MA 28) or ZP3 beta (MA 1, MA 2, MA 10, MA 27 and MA 30) and their relative affinities in competitive ELISA. Among the s...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(93)90047-l

    authors: Bagavant H,Yurewicz EC,Sacco AG,Talwar GP,Gupta SK

    更新日期:1993-04-01 00:00:00

  • Lack of effect of boar seminal vesicle fluid immunosuppressor factor on embryo development.

    abstract::The effects of an immunosuppressive factor (ISF) isolated from boar seminal vesicle fluid on in vitro and in vivo mouse development were investigated. It was found that the zona pellucida of porcine and mouse oocytes pre-incubated with ISF reacted in indirect immunofluorescence with antibodies against ISF. Further res...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(91)90054-t

    authors: Veselský L,Dostál J,Stanĕk R,Procházka R,Vinter P

    更新日期:1991-09-01 00:00:00

  • Impairment of the accumulation of decidual T cells, NK cells, and monocytes, and the poor vascular remodeling of spiral arteries, were observed in oocyte donation cases, regardless of the presence or absence of preeclampsia.

    abstract::In oocyte donation (OD) pregnancies, a fetus is a complete allograft to the maternal host and OD pregnancies are an independent risk factor for preeclampsia. Immunocompetent cells contribute to spiral artery remodeling and the failure of this process could contribute to the pathophysiology of preeclampsia. Recent data...

    journal_title:Journal of reproductive immunology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jri.2015.07.005

    authors: Nakabayashi Y,Nakashima A,Yoshino O,Shima T,Shiozaki A,Adachi T,Nakabayashi M,Okai T,Kushima M,Saito S

    更新日期:2016-04-01 00:00:00

  • Lipopolysaccharide-binding protein is produced in the epididymis and associated with spermatozoa and prostasomes.

    abstract::Lipopolysaccharide-binding protein (LBP) is an acute phase protein known to play a central role in the defense against Gram-negative bacteria. It binds lipopolysaccharides of Gram-negative bacteria and, after binding to CD14, the complex signals through Toll-like receptor (TLR)-4, eliciting host-defense responses, suc...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2005.01.005

    authors: Malm J,Nordahl EA,Bjartell A,Sørensen OE,Frohm B,Dentener MA,Egesten A

    更新日期:2005-06-01 00:00:00

  • Nonspecific immunity in pregnancy: monocyte surface Fcgamma receptor expression and function.

    abstract::The state of pregnancy is an immunological enigma during which the body must prevent rejection of the antigenically foreign fetus while at the same time maintain sufficient maternal host defense mechanisms to combat infection. Although most studies on the immunology of pregnancy focus on immune suppression, several st...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/s0165-0378(98)00076-x

    authors: Davis D,Kaufmann R,Moticka EJ

    更新日期:1998-11-01 00:00:00

  • Allogeneic reactivity of maternal lymphoid cells during the course of gestation. Modifications and sex differences in a local GVH assay.

    abstract::The immune reactivity of lymphoid cells from pregnant mice was studied during the course of pregnancy in primiparous and multiparous animals either " isopregnant " (male and female of same strain) or " allopregnant " (male and female differing at H-2), using a local GVH assay (CBA lymphoid cells injected into (CBA X A...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(84)90024-x

    authors: Dorić M,Kinsky RG,Voisin GA

    更新日期:1984-05-01 00:00:00

  • The role of apoptosis in human embryo implantation.

    abstract::The process of embryo attachment and invasion through the endometrial epithelial cells and subsequent implantation into the decidualized endometrial stroma is the groundbreaking step for the establishment of a successful pregnancy. Necessary prerequisites are a receptive endometrium, a good-quality embryo and a well-o...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jri.2015.02.002

    authors: Boeddeker SJ,Hess AP

    更新日期:2015-04-01 00:00:00

  • A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy.

    abstract::Focussing attention on cytokines at the materno-foetal interface represents one of the major advances made in the field. This owes much to the visionary views of Tom Wegmann, and to the changes brought about in the field by immunotrophism and Th1/Th2 paradigms. We review these briefly and also point out some emerging ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-0378(01)00119-x

    authors: Chaouat G,Zourbas S,Ostojic S,Lappree-Delage G,Dubanchet S,Ledee N,Martal J

    更新日期:2002-01-01 00:00:00

  • Risk factors for pregnancy failure in patients with antiphospholipid antibody positivity and prior pregnancy losses: A retrospective study.

    abstract:OBJECTIVES:To analyze the risk factors associated with pregnancy failure in patients with positive antiphospholipid antibodies (aPL) and prior pregnancy losses, with or without a diagnosis of antiphospholipid syndrome. METHODS:We retrospectively reviewed the medical records of all the pregnant patients with positive a...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2020.103171

    authors: Duan H,Li X,Liu C,Ge Y,Deng X

    更新日期:2020-09-01 00:00:00

  • Colony Stimulating Factors 1, 2, 3 and early pregnancy steps: from bench to bedside.

    abstract::Reproductive immunology applies general immunology principles to specialised targets, reproduction and development. The involvement of colony-stimulating factors (CSFs) in reproduction illustrates this. The CSF family includes CSF-1 or macrophage CSF (M-CSF), CSF-2 or granulocyte macrophage CSF (GM-CSF), and CSF-3 or ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jri.2015.01.005

    authors: Rahmati M,Petitbarat M,Dubanchet S,Bensussan A,Chaouat G,Ledee N

    更新日期:2015-06-01 00:00:00

  • Correlations of selected vaginal cytokine levels with pregnancy-related traits in women with bacterial vaginosis and mycoplasmas.

    abstract::The aim of this study was to examine correlations between vaginal inflammatory cytokines (IL-1alpha, IL-1beta, IL-6 and IL-8) and pregnancy-related traits (gestational age, birth-weight, BMI, weight gain during pregnancy and vaginal pH). Differences in correlation coefficients were examined among bacterial vaginosis (...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2008.02.001

    authors: Ryckman KK,Williams SM,Kalinka J

    更新日期:2008-07-01 00:00:00

  • Soluble HLA-G and control of angiogenesis.

    abstract::In this review, we summarize the results of a number of our recent in vitro and in vivo experiments demonstrating that, in addition to the immunoregulatory functions, soluble HLA-G molecules also affect endothelial cell activity. We have found that soluble HLA-G1 (also designated HLA-G5) inhibits endothelial cell prol...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jri.2007.03.007

    authors: Le Bouteiller P,Fons P,Herault JP,Bono F,Chabot S,Cartwright JE,Bensussan A

    更新日期:2007-12-01 00:00:00

  • Exposure to systemic and intrauterine inflammation leads to decreased pup survival via different placental mechanisms.

    abstract:PROBLEM:Exposure to systemic maternal inflammation (i.e., maternal sepsis, influenza, human immunodeficiency virus, or pyelonephritis) and intrauterine (IU) inflammation (i.e., chorioamnionitis or preterm labor) have been associated with adverse perinatal sequelae. Whether systemic and localized inflammation leading to...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2019.06.004

    authors: Lee JY,Shin NE,Na Q,Dong J,Chudnovets A,Li S,Novak CM,McLane MW,Lei J,Burd I

    更新日期:2019-06-01 00:00:00

  • Potential implications of chemokines in reproductive function: an attractive idea.

    abstract::Chemokines are a new family of cytokines specialised in attracting leukocytes, acting in physiological conditions and in pathological processes. A wide variety of cell types in response to exogenous irritants or endogenous mediators of the inflammatory reaction produce them. Pivotal parts of reproductive function are ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-0378(98)00031-x

    authors: Simón C,Caballero-Campo P,García-Velasco JA,Pellicer A

    更新日期:1998-07-01 00:00:00

  • Indomethacin blocks the immunosuppressive activity of rat testicular macrophages cultured in vitro.

    abstract::Macrophages are a prominent resident cell type in the interstitial tissue of the testis in several mammalian species. This presence in an immunologically-privileged site prompted an investigation of their ability to initiate and regulate lymphocyte proliferation in vitro. Isolated rat peripheral blood lymphocytes (PBL...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/0165-0378(95)91391-q

    authors: Kern S,Maddocks S

    更新日期:1995-03-01 00:00:00

  • Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice.

    abstract::Miscarriages in patients with antiphospholipid (aPL) antibodies have been attributed to thrombosis of placental vessels. However, we have shown that inflammation plays a crucial role in fetal injury. We identified tissue factor (TF), the major cellular activator of the coagulation cascade, as a key mediator in inflamm...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2009.03.003

    authors: Girardi G

    更新日期:2009-11-01 00:00:00

  • Expression and localization of cell adhesion molecules in human fetal membranes during parturition.

    abstract::There is increasing evidence to support the view that human parturition represents an inflammatory process. We have previously demonstrated that parturition is associated with leukocyte invasion and pro-inflammatory cytokine production in the cervix and myometrium. Furthermore, we have shown that several cell adhesion...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章

    doi:10.1016/j.jri.2004.04.003

    authors: Osman I,Crawford M,Jordan F,Young A,Norman J,Thomson A

    更新日期:2004-08-01 00:00:00