Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.


:Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains complex and involves a balance between innate signaling pathways and the adaptive immune response. Primary infection with HSV-2 induces toll-like receptor (TLR)-mediated Type I interferon (IFN) production, which establishes an antiviral state and activates multiple cell types, including natural killer cells and plasmacytoid dendritic cells. This innate response is not only crucial for controlling initial infection, but also for priming adaptive immune responses as well. Both humoral and cellular responses encompass adaptive immunity, although the former has been shown to be dispensable in response to HSV-2. Recently, numerous studies have attributed IFNγ producing CD4(+) T cells to be the key effector molecule responsible for clearing infection. It remains unclear whether regulatory T (Treg) cells are a source of aid or hindrance in the clearance of disease. Collectively, this review highlights the balance between innate and adaptive effector responses that contribute to the control and clearance of HSV-2 infection.


J Reprod Immunol


Chan T,Barra NG,Lee AJ,Ashkar AA




Has Abstract


2011-03-01 00:00:00














  • Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction.

    abstract:BACKGROUND:The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas. PATIENTS AND METHODS:We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Meister S,Kolben T,Beyer S,Hutter S,Hofmann S,Kuhn C,Messner J,Mayr D,Solano ME,Jegen M,Obermeier V,Mahner S,Arck P,Jeschke U

    更新日期:2020-06-01 00:00:00

  • Characterization of decidual leukocyte populations in cynomolgus and vervet monkeys.

    abstract::The objective of this study was the phenotypic and functional evaluation of decidual immune cells in the cynomolgus and vervet monkeys. Early pregnancy (days 36-42) deciduas were obtained by fetectomy for histological evaluation and decidual mononuclear leukocyte (MNL) isolation. While peripheral NK (pNK) cells in the...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Dambaeva SV,Breburda EE,Durning M,Garthwaite MA,Golos TG

    更新日期:2009-06-01 00:00:00

  • Influence of immunization with allogeneic spleen cells on the number of viable neonates in mice.

    abstract::Female CBA/J (H-2k) mice mated with male DBA/2J (H-2d) mice show a high level of fetal resorption, which can be reduced by immunization with BALB/c (H-2d) spleen cells. The morphologically defined fetal resorption rate upon which evaluation of the outcome of pregnancy has previously been based in this strain combinati...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Heine O,Neppert J,Mueller-Eckhardt G

    更新日期:1989-05-01 00:00:00

  • Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth.

    abstract::The central role of inflammatory processes in labour and delivery is now well-recognised. However, the biomolecular, immunological and endocrine mechanisms involved in the labour process, and the clinical manifestations of inflammation in pregnancy, are complex, variable and modulated by factors such as aetiology, eth...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Keelan JA

    更新日期:2018-02-01 00:00:00

  • Fc receptor blocking antibodies after active immunization for the treatment of recurrent spontaneous abortion.

    abstract::In a prospective study 140 couples who had at least three spontaneous abortions (RSA) were studied for the presence of Fc receptor blocking antibodies detected by the erythrocyte antibody rosette inhibition (EAI) assay, for anti-paternal cytotoxic antibodies (APCA), and for mixed lymphocyte culture inhibiting (MLCI) a...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kuhn U,Blasczyk R,Hojnacki B,Vögeler U,Luboldt W,Passarge E,Fischer WM,Grosse-Wilde H

    更新日期:1991-07-01 00:00:00

  • Uterine stromal cell suppression of pIgR production by uterine epithelial cells in vitro: a mechanism for regulation of pIgR production.

    abstract::Previous studies have shown that the polymeric Ig receptor (pIgR) is produced by rat uterine epithelial cells both in vivo and vitro. The expression of the pIgR is regulated by sex hormones and/or cytokines at mucosal sites, however the mechanism of regulation in the uterus is not clear. In these studies, co-culture o...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Richardson JM,Wira CR

    更新日期:1997-06-01 00:00:00

  • The nature of an iso-antigen of the human sperm membrane.

    abstract::An iso-antigen has been isolated from tritium-labelled human spermatozoa by detergent solubilization, lectin affinity chromatography and indirect immunoprecipitation using human iso-antisera. Isolated material was characterized by SDS-polyacrylamide gel electrophoresis. With these iso-antisera it was possible to isola...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Poulsen F

    更新日期:1983-01-01 00:00:00

  • Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study.

    abstract:PROBLEM:Markers of maternal inflammation may determine infant birth outcomes. METHOD OF STUDY:Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Yeates AJ,McSorley EM,Mulhern MS,Spence T,Crowe W,Grzesik K,Thurston SW,Watson GE,Myers GJ,Davidson PW,Shamlaye CF,van Wijngaarden E,Strain JJ

    更新日期:2020-02-01 00:00:00

  • Demonstration of the low affinity alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-R alpha) on human trophoblast and uterine cells.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a classical haematopoietic cytokine which has also been implicated in placental growth and development. In this study we have performed a detailed immunohistological localization of the low affinity GM-CSF receptor (GM-CSF-R alpha) in human first trimester i...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Jokhi PP,King A,Jubinsky PT,Loke YW

    更新日期:1994-03-01 00:00:00

  • Characterization of cDNA encoding a human sperm membrane protein sharing homology with Huntington protein.

    abstract::In our earlier study, we have reported the identification and characterization of a 57-kDa sperm membrane protein from human spermatozoa. The protein was found to be localized on the acrosome in acrosome intact spermatozoa and shifted to equatorial region after acrosomal induction. Further, we demonstrated that it pla...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Vijayalaxmi G,Raghavan VP,Reddy KV

    更新日期:2005-08-01 00:00:00

  • Galectins in angiogenesis: consequences for gestation.

    abstract::Members of the galectin family have been shown to exert several roles in the context of reproduction. They contribute to placentation, maternal immune regulation and facilitate angiogenesis encompassing decidualisation and placenta formation during pregnancy. In the context of neo-vascularisation, galectins have been ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Blois SM,Conrad ML,Freitag N,Barrientos G

    更新日期:2015-04-01 00:00:00

  • Analysis of immunoregulatory activity of a choriocarcinoma-derived factor: specific suppression of proliferative process of cell-mediated immune responses including LAK cell generation.

    abstract::The immunosuppressive activity of a JEG-3 choriocarcinoma-derived factor in human IL-2-dependent T cell responses has been studied, together with its effect on IL-2-independent T cell responses induced by 10 nM TPA. The factor completely suppressed the IL-2-independent proliferative responses of T cells but failed to ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Matsuzaki N,Saji F,Okada T,Sawai K,Kameda T,Tanizawa O

    更新日期:1991-02-01 00:00:00

  • New techniques on embryo manipulation.

    abstract::For many years, experience has been accumulated on embryo and gamete manipulation in livestock animals. The present work is a review of these techniques and their possible application in human embryology in specific cases. It is possible to manipulate gametes at different levels, producing paternal or maternal haploid...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Escribá MJ,Valbuena D,Remohí J,Pellicer A,Simón C

    更新日期:2002-05-01 00:00:00

  • Delineation of epitopes on porcine zona pellucida relevant for binding of sperm to oocyte using monoclonal antibodies.

    abstract::Seven monoclonal antibodies (MAs) generated against porcine zona pellucida glycoprotein, ZP3 (comprising both ZP3 alpha and ZP3 beta) were characterized for their specificities to ZP3 alpha (MA 7 and MA 28) or ZP3 beta (MA 1, MA 2, MA 10, MA 27 and MA 30) and their relative affinities in competitive ELISA. Among the s...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Bagavant H,Yurewicz EC,Sacco AG,Talwar GP,Gupta SK

    更新日期:1993-04-01 00:00:00

  • LPS mediated production of IL-1, PGE2 and PGF2alpha from term decidua involves tumour necrosis factor and tumour necrosis factor receptor p55.

    abstract::Prostaglandins, with cytokines involved as intermediate factors, may have an essential role in premature labour when infection is present. We therefore wanted to study tumour necrosis factor (TNF), in cytokine and prostaglandin production in reproductive tissue. Decidual cell cultures were established and cells were s...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Arntzen KJ,Egeberg K,Rahimipoor S,Vatten L,Austgulen R

    更新日期:1999-12-01 00:00:00

  • Involvement of trophoblast in embryo implantation: regulation by paracrine factors.

    abstract::In order to investigate the regulatory role of only one endometrial cell type on trophoblastic invasion, we explored the effects of culture medium conditioned by in vitro decidualised stromal cells (DCM) and of insulin-like growth factor binding protein-1 (IGFBP-1, the main secretory product of decidual cells) on the ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Bischof P,Meisser A,Campana A

    更新日期:1998-08-01 00:00:00

  • MicroRNAs in pregnancy.

    abstract::Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptiona...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Morales Prieto DM,Markert UR

    更新日期:2011-03-01 00:00:00

  • The obstetric antiphospholipid syndrome.

    abstract::The association of persistent presence of circulating antiphospholipid antibodies and thromboembolic events, (recurrent) pregnancy loss or both is termed antiphospholipid syndrome. Pregnancies in women with the syndrome should be regarded as at high-risk for complications. Optimal management consisting of close follow...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Derksen RH,de Groot PG

    更新日期:2008-01-01 00:00:00

  • Pregnancy and multiple sclerosis: feto-maternal immune cross talk and its implications for disease activity.

    abstract::Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system of presumed autoimmune origin. Intriguingly, pregnancy in female MS patients is associated with a substantial decrease in relapse rate. However, post-partum the relapse rate increases in a rebounding fashion above the rate ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Patas K,Engler JB,Friese MA,Gold SM

    更新日期:2013-03-01 00:00:00

  • Plasma pregnancy-associated alpha 2-glycoprotein concentrations in complications of pregnancy and foetal abnormality.

    abstract::Maternal plasma concentrations of pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG) were measured in normal pregnancy and in pregnancies complicated by apparent threatened abortion, pre-eclampsia or intrauterine growth retardation (IUGR). alpha 2-PAG levels were significantly decreased in those women who spontan...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Thomson AW,Powrie JK,Horne CH

    更新日期:1979-12-01 00:00:00

  • Differential expression of complement regulatory proteins on subpopulations of human trophoblast cells.

    abstract::Trophoblast cells forming the reactive interface between the mother and her semiallogeneic fetus risk attack by cellular and humoral elements of the maternal immune system. Biochemical, molecular, and immunohistologic studies have identified membrane cofactor protein (MCP) and decay accelerating factor (DAF) on tropho...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Hsi BL,Hunt JS,Atkinson JP

    更新日期:1991-04-01 00:00:00

  • Effects of maternal anti H-Y antibodies on fetal gonadal development.

    abstract::C57BL/6 inbred female mice preimmunized by serial injections of isogeneic male spleen cells were mated and the effects of the circulating anti H-Y antibodies on the fetal gonads and on their fertility were studied. Female mice receiving injections of saline formed one control group and those given female spleen cells ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Rao CS,Vaidya RA,Ambani LM

    更新日期:1981-07-01 00:00:00

  • The role of visfatin (PBEF/Nampt) in pregnancy complications.

    abstract::Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently r...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Pavlová T,Novák J,Bienertová-Vašků J

    更新日期:2015-11-01 00:00:00

  • Epidemiological studies on primipaternity and immunology in preeclampsia--a statement after twelve years of workshops.

    abstract::Hypertensive disorders of pregnancy (HDP) represent 10% of human births globally and the major complication preeclampsia has a 3-5% prevalence. The etiology of HDP remains uncertain; however, major advances have been made over the last 25 years. The Seventh International Workshop on Reproductive Immunology, Immunologi...

    journal_title:Journal of reproductive immunology

    pub_type: 历史文章,杂志文章,评审


    authors: Robillard PY,Dekker G,Chaouat G,Hulsey TC,Saftlas A

    更新日期:2011-05-01 00:00:00

  • Signal transduction pathways in human spermatozoa.

    abstract::Following ejaculation, sperm functions are regulated by interactions with the environment found in the female genital tract. Here spermatozoa become 'capacitated' (i.e. they acquire the capability of completing the acrosome reaction and successfully fertilizing the egg), through a series of surface and intracellular t...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Baldi E,Luconi M,Bonaccorsi L,Forti G

    更新日期:2002-01-01 00:00:00

  • Assessment of the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine in domestic male and female cats (Felis catus).

    abstract::This study has assessed the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine administered to intact domestic cats. Fifteen kittens, 8-9 weeks of age, were allocated to three unequal treatment groups: group 1, 1 male control cat; group 2, 5 females administered 10 microg of GnR...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Robbins SC,Jelinski MD,Stotish RL

    更新日期:2004-12-01 00:00:00

  • Complement component deposition in uteroplacental (spiral) arteries in normal human pregnancy.

    abstract::There is conflicting evidence for the deposition of complement in spiral arteries in normal and abnormal human pregnancies. The immunogold silver staining (IGSS) technique was used to investigate the distribution of C1q, C3d, C4, C6 and C9 within the spiral arteries of formalin-fixed normal pregnancy hysterectomy spec...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Wells M,Bennett J,Bulmer JN,Jackson P,Holgate CS

    更新日期:1987-10-01 00:00:00

  • Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis.

    abstract:AIM:Th17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease. METHODS:The perc...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Gogacz M,Winkler I,Bojarska-Junak A,Tabarkiewicz J,Semczuk A,Rechberger T,Adamiak A

    更新日期:2016-09-01 00:00:00

  • Expression of Fas-ligand in first trimester and term human placental villi.

    abstract::The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Hammer A,Dohr G

    更新日期:2000-03-01 00:00:00

  • Protective immunity against HSV-2 in the mouse vagina.

    abstract::Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Parr MB,Parr EL

    更新日期:1997-11-30 00:00:00