Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.


:Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains complex and involves a balance between innate signaling pathways and the adaptive immune response. Primary infection with HSV-2 induces toll-like receptor (TLR)-mediated Type I interferon (IFN) production, which establishes an antiviral state and activates multiple cell types, including natural killer cells and plasmacytoid dendritic cells. This innate response is not only crucial for controlling initial infection, but also for priming adaptive immune responses as well. Both humoral and cellular responses encompass adaptive immunity, although the former has been shown to be dispensable in response to HSV-2. Recently, numerous studies have attributed IFNγ producing CD4(+) T cells to be the key effector molecule responsible for clearing infection. It remains unclear whether regulatory T (Treg) cells are a source of aid or hindrance in the clearance of disease. Collectively, this review highlights the balance between innate and adaptive effector responses that contribute to the control and clearance of HSV-2 infection.


J Reprod Immunol


Chan T,Barra NG,Lee AJ,Ashkar AA




Has Abstract


2011-03-01 00:00:00














  • Expression of indoleamine 2,3-dioxygenase in the rhesus monkey and common marmoset.

    abstract::Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan degradation along the kynurenine pathway, and is hypothesized to limit tryptophan availability at embryo implantation and prevent maternal T cell activation at the maternal-fetal interface. To determine if nonhuman primates ar...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Drenzek JG,Breburda EE,Burleigh DW,Bondarenko GI,Grendell RL,Golos TG

    更新日期:2008-07-01 00:00:00

  • The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause.

    abstract::A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Keller ET,Zhang J,Yao Z,Qi Y

    更新日期:2001-04-01 00:00:00

  • The nature of an iso-antigen of the human sperm membrane.

    abstract::An iso-antigen has been isolated from tritium-labelled human spermatozoa by detergent solubilization, lectin affinity chromatography and indirect immunoprecipitation using human iso-antisera. Isolated material was characterized by SDS-polyacrylamide gel electrophoresis. With these iso-antisera it was possible to isola...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Poulsen F

    更新日期:1983-01-01 00:00:00

  • The role of visfatin (PBEF/Nampt) in pregnancy complications.

    abstract::Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently r...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Pavlová T,Novák J,Bienertová-Vašků J

    更新日期:2015-11-01 00:00:00

  • Differential expression of complement regulatory proteins on subpopulations of human trophoblast cells.

    abstract::Trophoblast cells forming the reactive interface between the mother and her semiallogeneic fetus risk attack by cellular and humoral elements of the maternal immune system. Biochemical, molecular, and immunohistologic studies have identified membrane cofactor protein (MCP) and decay accelerating factor (DAF) on tropho...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Hsi BL,Hunt JS,Atkinson JP

    更新日期:1991-04-01 00:00:00

  • Immunological regulation of trophoblast invasion.

    abstract::In investigating the immunological regulation of trophoblast invasion, emphasis is frequently placed on the constitution of the implantation site and its specific characteristics. However trophoblast cells are able of invading into not only the uterine tissue, but in the case of ectopic pregnancies also invade into ot...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Hammer A

    更新日期:2011-06-01 00:00:00

  • Peptide presentation and NK inhibition by HLA-G.

    abstract::The expression of the nonclassical MHC class Ib molecule HLA-G is nearly exclusively restricted to the feto-maternal interface during pregnancy. There it probably serves the same physiological functions already known for classical MHC class I molecules; these include peptide presentation, natural killer cell (NK) inhi...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Münz C,Stevanović S,Rammensee HG

    更新日期:1999-07-01 00:00:00

  • Indomethacin blocks the immunosuppressive activity of rat testicular macrophages cultured in vitro.

    abstract::Macrophages are a prominent resident cell type in the interstitial tissue of the testis in several mammalian species. This presence in an immunologically-privileged site prompted an investigation of their ability to initiate and regulate lymphocyte proliferation in vitro. Isolated rat peripheral blood lymphocytes (PBL...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kern S,Maddocks S

    更新日期:1995-03-01 00:00:00

  • Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies.

    abstract::CD14, the major receptor for bacterial lipopolysaccharide (LPS) as well as other microbial antigens, is a component of the innate immune system. We hypothesized that a single nucleotide C>T polymorphism at position -159 in the CD14 gene that results in elevated CD14 production would influence susceptibility to preterm...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kalish RB,Vardhana S,Normand NJ,Gupta M,Witkin SS

    更新日期:2006-06-01 00:00:00

  • Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis.

    abstract:AIM:Th17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease. METHODS:The perc...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Gogacz M,Winkler I,Bojarska-Junak A,Tabarkiewicz J,Semczuk A,Rechberger T,Adamiak A

    更新日期:2016-09-01 00:00:00

  • Antigen phenotype of cultured decidual stromal cells of human term decidua.

    abstract::We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Oliver C,Cowdrey N,Abadía-Molina AC,Olivares EG

    更新日期:1999-11-01 00:00:00

  • Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure.

    abstract::Considerable work is being carried out on endometrial NK cells to determine whether they play a role in successful pregnancy outcome. In addition there is debate about whether measurements of uNK should be included in the clinical assessment for women with recurrent implantation failure or recurrent miscarriage. A hin...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,多中心研究


    authors: Lash GE,Bulmer JN,Li TC,Innes BA,Mariee N,Patel G,Sanderson J,Quenby S,Laird SM

    更新日期:2016-08-01 00:00:00

  • The lymphocyte and macrophage profile in the pancreas and spleen of NOD mice: percentage of interleukin-2 and prolactin receptors on immunocompetent cell subsets.

    abstract::The NOD mouse is a model for autoimmune diabetes that develops symptoms similar to Type I diabetes. The incidence of diabetes is greater in females but the degree of insulitis is comparable in both sexes. The purpose of this study was to assess the populations of lymphocytes and macrophages in the pancreas and spleen ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Hawkins TA,Gala RR,Dunbar JC

    更新日期:1996-11-01 00:00:00

  • Glycodelin regulates the numbers and function of peripheral natural killer cells.

    abstract::Natural killer (NK) cells comprise of ∼70% of the immune cell population in the maternal decidua and ∼15% of the mononuclear cells in the peripheral blood. The decidual NK cells capable of producing high levels of cytokines are functionally distinct from the peripheral NK cells that exhibit high cytotoxicity. The numb...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Dixit A,Karande AA

    更新日期:2020-02-01 00:00:00

  • Secondary recurrent miscarriage is associated with previous male birth.

    abstract::Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor h...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Ooi PV,Russell N,O'Donoghue K

    更新日期:2011-01-01 00:00:00

  • High serum IGF-1 levels are associated with pregnancy loss following frozen-thawed euploid embryo transfer cycles.

    abstract::An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Irani M,Nasioudis D,Witkin SS,Gunnala V,Spandorfer SD

    更新日期:2018-06-01 00:00:00

  • Gene fusion of molecular adjuvant C3d to hCGbeta enhances the anti-hCGbeta antibody response in DNA immunization.

    abstract:OBJECTIVE:To express the hCGbeta-C3d3 fusion protein in a CHO cell continual expression system to investigate further the adjuvant effects of C3d on contraceptive vaccination. METHOD:We constructed a plasmid pcDNA3-hCGbeta-C3d3 which contains three copies of murine C3d cDNA and the hCGbeta gene by cloning the chimeric...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Li DJ,Wang HM,Li L,Zhao XR,Wang MY,Zhu Y,Meng Y,Yuan MM

    更新日期:2003-12-01 00:00:00

  • Alternative theories: Pregnancy and immune tolerance.

    abstract::For some time, reproductive immunologists have worked to understand the balance between maternal tolerance of the fetus, maternal health, and fetal protection which leads to successful pregnancy in mammalian species. We have always understood the potential importance of multiple factors, including nutrition, genetics,...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Bonney EA

    更新日期:2017-09-01 00:00:00

  • Immunoregulatory activity of cells from lymph nodes draining the uterus of allopregnant mice.

    abstract::The presence of a local immunosuppressive environment in the vicinity of the developing fetus has been suggested to explain survival of the semi-allogeneic fetus in a potentially hostile maternal immunologic environment. The presence of nonspecific suppressor cells in the uterus of pregnant mice has been well-document...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kamel S,Wood GW

    更新日期:1990-06-01 00:00:00

  • Low levels of serum asymmetric antibodies as a marker of threatened pregnancy.

    abstract::Tolerance to the developing fetus is thought to be accomplished through the action of several molecules that are able to modulate the maternal immune response. Among several mechanisms involved in pregnancy maintenance, progesterone-induced immunomodulation, asymmetric antibody (AAb) production, indoleamine 2,3-dioxyg...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Barrientos G,Fuchs D,Schröcksnadel K,Ruecke M,Garcia MG,Klapp BF,Raghupathy R,Miranda S,Arck PC,Blois SM

    更新日期:2009-01-01 00:00:00

  • Demonstration of the low affinity alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-R alpha) on human trophoblast and uterine cells.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a classical haematopoietic cytokine which has also been implicated in placental growth and development. In this study we have performed a detailed immunohistological localization of the low affinity GM-CSF receptor (GM-CSF-R alpha) in human first trimester i...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Jokhi PP,King A,Jubinsky PT,Loke YW

    更新日期:1994-03-01 00:00:00

  • Phytohaemagglutinin as a molecular probe to study the membrane constituents of human X- and Y-bearing spermatozoa.

    abstract::Phytohaemagglutinin (PHA) was employed to study the constituents of the cell membrane in X- and Y-bearing human spermatozoa. The presence of certain receptors for PHA was revealed in the equatorial region of about 50% of the spermatozoa. To determine the association of the equatorial staining by PHA with one of the su...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Hegde UC,Shastry PR,Rao SS

    更新日期:1981-03-01 00:00:00

  • Hormonal control of the secretory immune system of the human uterine cervix.

    abstract::A quantitative immunohistochemical study of IgA-containing plasma cells in the human uterine cervix has shown that the number of such cells increases during the late secretory phase of the menstrual cycle but decreases in the early secretory phase of the cycle, in pregnancy, in cystic glandular hyperplasia of the endo...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Murdoch AJ,Buckley CH,Fox H

    更新日期:1982-02-01 00:00:00

  • Immunological and biochemical markers in preeclampsia.

    abstract::A basic precondition for the development of preeclampsia is the presence of placental trophoblast cells in the maternal blood circulation. On the other hand, while trophoblast cells are present in the blood of all pregnant women, preeclampsia occurs in only 2-5% of them. Evidently, other factors play a crucial role. T...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Kestlerová A,Feyereisl J,Frisová V,Měchurová A,Šůla K,Zima T,Běláček J,Madar J

    更新日期:2012-12-01 00:00:00

  • Effects of glycodelins on functional competence of spermatozoa.

    abstract::Glycodelin is a glycoprotein with 4 known glycoforms, namely glycodelin-S, glycodelin-A, glycodelin-F and glycodelin-C. The glycoforms are present in the female reproductive tract which the spermatozoa must pass through before fertilizing the oocyte. Thus the spermatozoa interact with each of these glycoforms in succe...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Yeung WS,Lee KF,Koistinen R,Koistinen H,Seppälä M,Chiu PC

    更新日期:2009-12-01 00:00:00

  • Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion.

    abstract::Scattered in the amniotic epithelium of the human term placenta are pluripotent stem cell marker-positive cells. Unlike other parts of the placenta, amniotic epithelial (AE) cells are derived from pluripotent epiblasts. It is hypothesized that most epiblast-derived fetal AE cells are positive for stem cell markers at ...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Izumi M,Pazin BJ,Minervini CF,Gerlach J,Ross MA,Stolz DB,Turner ME,Thompson RL,Miki T

    更新日期:2009-07-01 00:00:00

  • HLA-G suppresses proliferation of CD4(+) T-lymphocytes.

    abstract::HLA-G is a non-classical MHC class 1 molecule, expressed primarily on human foetal trophoblast cells, which exhibits almost no genetic polymorphism. Because of these unusual features, HLA-G has been suggested to help prevent maternal immune attack of the semi-allogeneic foetus. The aim of these experiments was to inve...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Bainbridge DR,Ellis SA,Sargent IL

    更新日期:2000-08-01 00:00:00

  • New techniques on embryo manipulation.

    abstract::For many years, experience has been accumulated on embryo and gamete manipulation in livestock animals. The present work is a review of these techniques and their possible application in human embryology in specific cases. It is possible to manipulate gametes at different levels, producing paternal or maternal haploid...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章,评审


    authors: Escribá MJ,Valbuena D,Remohí J,Pellicer A,Simón C

    更新日期:2002-05-01 00:00:00

  • The effect of neonatal thymectomy on the induction of autoimmune orchitis in rats.

    abstract::The objective of these experiments was to determine the effects of neonatal thymectomy on the induction of experimental autoimmune orchitis in inbred rats of the Fischer 344 and Lewis strains. It was found that thymectomy alone in Lewis rats, and thymectomy followed by immunization with testicular extract in both Lewi...

    journal_title:Journal of reproductive immunology

    pub_type: 杂志文章


    authors: Lipscomb HL,Gardner PJ,Sharp JG

    更新日期:1979-12-01 00:00:00

  • Prostaglandin F2 alpha immunization of prepubertal beef heifers: effects of conjugate dose and timing of immunization relative to puberty on the onset of puberty and subsequent ovarian function.

    abstract::Fifty-six prepubertal Hereford cross Friesian heifers were assigned to seven treatment groups: (1) primary (day 0) and booster (day 41) using 10 mg human serum albumin (HSA) (control); (2) primary and booster (day 41) immunizations using 3.3 mg prostaglandin F2 alpha PGF-HSA conjugate; (3) primary and booster (day 83)...

    journal_title:Journal of reproductive immunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Crowe MA,Enright WJ,Roche JF

    更新日期:1994-12-01 00:00:00