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Elevated systemic galectin-1 levels characterize HELLP syndrome.

Abstract：

:Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Schnabel A,Blois SM,Meint P,Freitag N,Ernst W,Barrientos G,Conrad ML,Rose M,Seelbach-Göbel B

doi

10.1016/j.jri.2016.02.002

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

38-43

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(15)30073-5

journal_volume

114

pub_type

临床试验,杂志文章

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