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Maternal-fetal disparity at multiple minor histocompatibility loci affects the weight of the feto-placental unit in mice.

Abstract：

:Inbred mice from selected unrelated and congenic strains were mated to determine the relative effects of maternal-fetal disparity at major histocompatibility complex (H-2) and non-H-2 minor histocompatibility antigens on the feto-placental unit at 14 days of gestation. A significant increase in weight of the feto-placental unit was observed only when mother and fetus differed at multiple minor histocompatibility loci. No increase in the weight of the feto-placental unit was observed when mother and fetus differed only at H-2. These results suggest that immunostimulation of the fetus results from a maternal response to minor histocompatibility antigens and not to H-2 antigens.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Hamilton BL,Hamilton A,Hamilton MS

doi

10.1016/0165-0378(85)90045-2

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

257-61

issue

2-3

eissn

0165-0378

issn

1872-7603

pii

0165-0378(85)90045-2

journal_volume

8

pub_type

杂志文章

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