Abstract:
:HLA-G is a non-classical MHC class 1 molecule, expressed primarily on human foetal trophoblast cells, which exhibits almost no genetic polymorphism. Because of these unusual features, HLA-G has been suggested to help prevent maternal immune attack of the semi-allogeneic foetus. The aim of these experiments was to investigate the effects of HLA-G on T-lymphocyte responses by using MHC class II-bearing HLA-G transfectants as stimulators of a mixed lymphocyte reaction. The presence of HLA-G, but not classical HLA class I, on the surface of stimulator cells markedly suppressed thymidine incorporation by peripheral blood mononuclear responder cells from a class I-similar, class II-dissimilar male. The suppressive effect of HLA-G on the mixed lymphocyte reaction persisted after depletion of phagocytes and CD8(+) T-cells from the responder population, but the mixed lymphocyte reaction was entirely abolished by depletion of CD4(+) T-cells. These results suggest that HLA-G exerts a direct suppressive effect on CD4(+) T-lymphocytes, even in the absence of the CD8(+) cells with which other human MHC class I molecules are thought to interact. Thus, HLA-G may allow the foetus to escape maternal immune attack by modulating CD4(+) T-cell activity.
journal_name
J Reprod Immunoljournal_title
Journal of reproductive immunologyauthors
Bainbridge DR,Ellis SA,Sargent ILdoi
10.1016/s0165-0378(00)00070-xsubject
Has Abstractpub_date
2000-08-01 00:00:00pages
17-26issue
1eissn
0165-0378issn
1872-7603pii
S0165-0378(00)00070-Xjournal_volume
48pub_type
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abstract::Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a grea...
journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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更新日期:1990-03-01 00:00:00
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journal_title:Journal of reproductive immunology
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更新日期:1995-07-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1980-12-01 00:00:00
abstract::Prolactin (PRL) was originally identified by its ability to stimulate mammary development and lactation, and its essential roles other than lactation have recently been implicated in female reproduction. However, little is known about PRL-mediated events in pregnancy. The tryptophan catabolism enzyme indoleamine 2,3-d...
journal_title:Journal of reproductive immunology
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00
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journal_title:Journal of reproductive immunology
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更新日期:1986-12-01 00:00:00
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更新日期:1994-03-01 00:00:00
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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