当前位置： SCI文献检索 > JOURNAL OF REPRODUCTIVE IMMUNOLOGY期刊下所有文献 > Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery.

Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery.

Abstract：

INTRODUCTION:Mice disrupted for the interleukin (IL)-18 gene appear more disposed to preterm delivery (PTD) induced by inflammation. A synergy between IL-18 and IL-12 has been suggested. The objective of this study was to investigate a possible relation between human maternal serum levels of IL-18, IL-12 and spontaneous PTD. MATERIALS AND METHODS:A cohort of 93 consecutive women with symptoms of threatening PTD on admission was enrolled at the delivery ward, Aarhus University Hospital, Denmark. MEASURES:Serum IL-18 and IL-12 measured using Luminex xMAP technology. Endpoint: PTD before 34 weeks gestation. RESULTS:Pregnant women admitted with symptoms of threatening PTD and delivering before 34 weeks of gestation had significantly lower levels of IL-18 compared to women delivering at or after 34 weeks of gestation (medians: 14.5 versus 26.6 pg/ml; p=0.035). IL-12 levels were not different in women delivering before or after 34 weeks of gestation. Patients having low IL-18 (below the 25-percentile) and high IL-12 (above the 75-percentile) had a twofold increase in risk of delivering before 34 weeks of gestation (RR 2.1 [1.7-2.6]). CONCLUSION:Results from this study indicate, that low serum IL-18 level could be associated with PTD in women with symptoms of PTD. A possible interaction between IL-18 and IL-12 was found, as the risk of delivering before 34 weeks is increased with the combination of low IL-18 and high IL-12, but further studies are warranted to investigate these interleukins and their possible role in PTD.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Ekelund CK,Vogel I,Skogstrand K,Thorsen P,Hougaard DM,Langhoff-Roos J,Jacobsson B

doi

10.1016/j.jri.2007.07.002

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

179-85

issue

2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(07)00193-3

journal_volume

77

pub_type

杂志文章

相关文献

JOURNAL OF REPRODUCTIVE IMMUNOLOGY文献大全
  • Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules.

    abstract：:Several members of the immunoglobulin-like transcript (ILT), also called leukocyte immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon binding of these ligands. The ligands for ILT2 (LIR1/CD...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(02)00024-4

    authors： Petroff MG,Sedlmayr P,Azzola D,Hunt JS

    更新日期：2002-07-01 00:00:00

  • Expression and localization of cell adhesion molecules in human fetal membranes during parturition.

    abstract：:There is increasing evidence to support the view that human parturition represents an inflammatory process. We have previously demonstrated that parturition is associated with leukocyte invasion and pro-inflammatory cytokine production in the cervix and myometrium. Furthermore, we have shown that several cell adhesion...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2004.04.003

    authors： Osman I,Crawford M,Jordan F,Young A,Norman J,Thomson A

    更新日期：2004-08-01 00:00:00

  • Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts.

    abstract：:Placental hypoxia following the immature remodeling of spiral arteries by extravillous cytotrophoblasts (CTs) is focused on the pathogenesis of pre-eclampsia. At the same time, the expression of human leukocyte antigen (HLA)-G is decreased at the protein and mRNA levels in the pre-eclamptic placenta. In view of the po...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2004.07.001

    authors： Nagamatsu T,Fujii T,Yamashita T,Miki A,Kanai T,Kusumi M,Osuga Y,Kozuma S,Taketani Y

    更新日期：2004-10-01 00:00:00

  • Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor.

    abstract：:Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regula...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2014.04.001

    authors： Koucký M,Malíčková K,Cindrová-Davies T,Germanová A,Pařízek A,Kalousová M,Hájek Z,Zima T

    更新日期：2014-12-01 00:00:00

  • Maternal monocytes in pregnancy and preeclampsia in humans and in rats.

    abstract：:Monocytes are short-lived cells, arising from the bone marrow and maturing in the circulation. They play an important role in immune responses and are thought to be important for healthy pregnancy. In humans, 3 subpopulations of monocytes have been identified: classical, intermediate and non-classical monocytes. These...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2016.06.009

    authors： Faas MM,de Vos P

    更新日期：2017-02-01 00:00:00

  • Molecular signature and functional analysis of uterine ILCs in mouse pregnancy.

    abstract：:In addition to natural killer cells, other innate lymphoid cells have recently been identified in the mouse and human uterus, but their roles in successful pregnancy remain poorly defined. In this study, we examined the dynamic changes of uterine innate lymphoid cells throughout pregnancy in mice. We found that the to...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2017.09.003

    authors： Li M,Gao Y,Yong L,Huang D,Shen J,Liu M,Ren C,Hou X

    更新日期：2017-09-01 00:00:00

  • Indomethacin blocks the immunosuppressive activity of rat testicular macrophages cultured in vitro.

    abstract：:Macrophages are a prominent resident cell type in the interstitial tissue of the testis in several mammalian species. This presence in an immunologically-privileged site prompted an investigation of their ability to initiate and regulate lymphocyte proliferation in vitro. Isolated rat peripheral blood lymphocytes (PBL...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(95)91391-q

    authors： Kern S,Maddocks S

    更新日期：1995-03-01 00:00:00

  • The IGF family and folliculogenesis.

    abstract：:The process of ovarian follicular development is a long and arduous one, marked by dramatic proliferation and differentiation of both the somatic and germ cell elements. To a large extent, this explosive agenda is under the control of conventional endocrine principles, involving hormones such as pituitary gonadotropin...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-0378(98)00026-6

    authors： Adashi EY

    更新日期：1998-08-01 00:00:00

  • Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate.

    abstract：:Effector cells associated with an aborting fetus appear to be both thymus derived (T) and natural killer (NK) cells. In order to test the hypothesis that NK cells are a major effector mediating early spontaneous abortion (less than day 8-10), CBA female mice mated by DBA/2 males were treated with either polyinosinic/c...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(87)90018-0

    authors： de Fougerolles AR,Baines MG

    更新日期：1987-06-01 00:00:00

  • Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth.

    abstract：:The central role of inflammatory processes in labour and delivery is now well-recognised. However, the biomolecular, immunological and endocrine mechanisms involved in the labour process, and the clinical manifestations of inflammation in pregnancy, are complex, variable and modulated by factors such as aetiology, eth...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2017.12.004

    authors： Keelan JA

    更新日期：2018-02-01 00:00:00

  • Human seminal plasma is a potent inhibitor of natural killer cell activity in vitro.

    abstract：:The effect of human seminal plasma on the natural killer (NK) activity of human peripheral blood leukocytes in vitro has been investigated. Small concentrations (as low as 0.01% v/v) of seminal plasma were found to inhibit the ability of human peripheral blood leukocytes to lyse K562 target cells. These inhibitory eff...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(85)90078-6

    authors： James K,Szymaniec S

    更新日期：1985-08-01 00:00:00

  • Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit.

    abstract：:The feasibility of producing epitope-specific antigens by mutation of the gene is demonstrated, the aim being to eliminate unwanted surface epitopes yet allowing the natural folding of the protein to maintain the desired epitope(s). The model protein is the beta subunit of human chorionic gonadotropin (hCG beta) which...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(96)00978-3

    authors： Jackson AM,Klonisch T,Lapthorn AJ,Berger P,Isaacs NW,Delves PJ,Lund T,Roitt IM

    更新日期：1996-08-01 00:00:00

  • ELISA test for the detection of an immunological blocking factor in human pregnancy serum.

    abstract：:We have previously shown that progesterone-treated lymphocytes of healthy pregnant women can produce a 34 kDa protein, progesterone-induced blocking factor (PIBF) capable of blocking lymphocyte function in vitro. Lymphocytes of women with idiopathic threatened pre-term delivery failed to produce this factor. On the as...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(89)90003-x

    authors： Szekeres-Bartho J,Varga P,Pejtsik B

    更新日期：1989-09-01 00:00:00

  • Cytokines in recurrent pregnancy loss.

    abstract：:Cytokines seem to play a critical role in the pathogenesis of unexplained recurrent pregnancy loss (RPL). Th1 cytokines have been shown to exert deleterious effects on pregnancy, inhibiting foetal growth and development. On the other hand, Th2 cytokines have been associated with successful pregnancy. The purpose of th...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2003.10.004

    authors： Daher S,de Arruda Geraldes Denardi K,Blotta MH,Mamoni RL,Reck AP,Camano L,Mattar R

    更新日期：2004-06-01 00:00:00

  • Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study.

    abstract：PROBLEM:Markers of maternal inflammation may determine infant birth outcomes. METHOD OF STUDY:Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2019.102623

    authors： Yeates AJ,McSorley EM,Mulhern MS,Spence T,Crowe W,Grzesik K,Thurston SW,Watson GE,Myers GJ,Davidson PW,Shamlaye CF,van Wijngaarden E,Strain JJ

    更新日期：2020-02-01 00:00:00

  • Peripheral K cells in normal human pregnancy: decrease during pregnancy and increase after delivery.

    abstract：:Peripheral blood levels of K cells were measured in normal pregnant and post-partum women by a plaque-forming cell technique that detects K cells on the basis of their activity of antibody-dependent cell-mediated cytotoxicity (ADCC). Peripheral K cells decreased throughout normal pregnancy (n = 46; 7.8 +/- 3.4%, P les...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(89)90042-9

    authors： Asari S,Iwatani Y,Amino N,Tanizawa O,Miyai K

    更新日期：1989-03-01 00:00:00

  • Reflections upon immunological mechanisms involved in fertility, pregnancy and parasite infections.

    abstract：:During a pregnancy, the mother accepts her semi-allogeneic fetus with no signs of immunological rejection. Therefore, some modulation of the maternal immune system must occur. Similarly, changes in the host's immune system occurs during infections with parasites. In a study conducted in an endemic area in Bolivia, it ...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jri.2019.08.001

    authors： Persson G,Ekmann JR,Hviid TVF

    更新日期：2019-11-01 00:00:00

  • Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B--implications for menstrual shock.

    abstract：:Menstrual toxic shock syndrome (mTSS) is an acute systemic inflammatory disease associated with the superantigenic exotoxin, toxic shock syndrome toxin (TSST)-1, produced by Staphylococcus aureus and the use of high absorbency tampons. Even though S. aureus is capable of elaborating several other superantigenic exotox...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2006.06.007

    authors： Rajagopalan G,Smart MK,Murali N,Patel R,David CS

    更新日期：2007-02-01 00:00:00

  • Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion.

    abstract：:Scattered in the amniotic epithelium of the human term placenta are pluripotent stem cell marker-positive cells. Unlike other parts of the placenta, amniotic epithelial (AE) cells are derived from pluripotent epiblasts. It is hypothesized that most epiblast-derived fetal AE cells are positive for stem cell markers at ...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2009.02.007

    authors： Izumi M,Pazin BJ,Minervini CF,Gerlach J,Ross MA,Stolz DB,Turner ME,Thompson RL,Miki T

    更新日期：2009-07-01 00:00:00

  • Antigen phenotype of cultured decidual stromal cells of human term decidua.

    abstract：:We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(99)00041-8

    authors： Oliver C,Cowdrey N,Abadía-Molina AC,Olivares EG

    更新日期：1999-11-01 00:00:00

  • CXCR7 and syndecan-4 are potential receptors for CXCL12 in human cytotrophoblasts.

    abstract：:The placenta forms the interface between the mother and the fetus. During placental development cytotrophoblasts differentiate to form the syncytium or to invade the decidual wall to breach maternal vessels and establish the blood flow in the intervillous space. This process is still not well understood but it is prop...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2011.01.016

    authors： Schanz A,Baston-Bust D,Krussel JS,Heiss C,Janni W,Hess AP

    更新日期：2011-04-01 00:00:00

  • Characterisation of the soluble fraction of human syncytiotrophoblast microvillous plasma membrane-associated proteins.

    abstract：:Syncytiotrophoblast microvillous plasma membrane (StMPM) preparations were obtained from human full-term placentae by previously published methods of cold saline extraction and phase centrifugation. Purity of these preparations was assessed by electron microscopy, enzyme analysis and hydroxyproline content. IgG, album...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(79)90013-5

    authors： Ogbimi AO,Johnson PM,Brown PJ,Fox H

    更新日期：1979-07-01 00:00:00

  • Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.

    abstract：:Despite immense effort, the development of vaccines effective at mucosal sites has proceeded at a faltering pace. Efforts concentrating on humoral immunity but neglecting cellular immunity may be misdirected by ignoring many viral mucosal pathogens. Improved understanding of the development and maintenance of lymphocy...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/s0165-0378(01)00110-3

    authors： Gould DS,Ploegh HL,Schust DJ

    更新日期：2001-10-01 00:00:00

  • Reduction in uterine intra-epithelial lymphocytes during early gestation in pigs.

    abstract：:The numbers of intra-epithelial lymphocytes per 5 mm of uterine epithelium were counted in cyclic (n = 18) and pregnant (n = 18) gilts on days 10, 13, 16 and 19 postestrus. In cyclic animals these cells increased (P less than 0.01) from 26.4 +/- 1.1 per 5 mm at the mid-luteal phase (day 10) to 47.7 +/- 1.5 per 5 mm at...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(88)90034-4

    authors： King GJ

    更新日期：1988-10-01 00:00:00

  • Anticollagen antibody responses in DBA/1 (H-2q) mice associated with type II collagen-induced arthritis and the effect of pregnancy.

    abstract：:We have previously shown that DBA/1 mice immunized with heterologous type II collagen showed remission of the subsequent collagen-induced arthritis (CIA) when pregnant, but experienced exacerbation postpartum. Measurement of anticollagen antibody (aCa) responses by ELISA in primiparous mice immunized at day 1 of pregn...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(88)90007-1

    authors： Whyte A,Hasan Z,Rutter F

    更新日期：1988-08-01 00:00:00

  • Potential implications of chemokines in reproductive function: an attractive idea.

    abstract：:Chemokines are a new family of cytokines specialised in attracting leukocytes, acting in physiological conditions and in pathological processes. A wide variety of cell types in response to exogenous irritants or endogenous mediators of the inflammatory reaction produce them. Pivotal parts of reproductive function are ...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-0378(98)00031-x

    authors： Simón C,Caballero-Campo P,García-Velasco JA,Pellicer A

    更新日期：1998-07-01 00:00:00

  • Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats.

    abstract：:Cytokines present in the reproductive system play an important role both in the modulation of immune responses to infectious challenge and in the establishment and maintenance of pregnancy. Interleukin 18 (IL-18) has been regarded as an important regulator of innate and acquired immune response, but its expression and...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/j.jri.2011.07.002

    authors： Wang Y,Zhang X,Zhang Y,Xu H,Fang G

    更新日期：2011-12-01 00:00:00

  • The effect of pregnancy on humoral rejection in patients after vascularized organ transplantation.

    abstract：:The aim of the study was to evaluate the effect of pregnancy on the production of donor- and nondonor-specific anti-human leukocyte antigen antibodies (anti-HLA Abs) in organ allograft recipients. The study group included four pregnant kidney (RT) and four liver (LT) transplant recipients. The genotype of HLA class I ...

    journal_title：Journal of reproductive immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jri.2015.08.005

    authors： Cyganek A,Nowaczyk M,Sańko-Resmer J,Pietrzak B,Grzechocińska B,Pączek L,Międzybrodzki R,Wielgoś M

    更新日期：2015-11-01 00:00:00

  • Antisperm autoantibody responses to vasectomy and vasovasostomy in Fischer and Lewis rats.

    abstract：:Antisperm autoantibodies were studied in Fischer and Lewis strains of rats after either vasectomy, vasectomy followed one month later by vasovasostomy, or sham operations. The time course of antibody response to sperm protein autoantigens was assayed by Western blot analysis of sera obtained at intervals up to 3 month...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(94)00904-l

    authors： Flickinger CJ,Howards SS,Bush LA,Baker LA,Herr JC

    更新日期：1995-02-01 00:00:00

  • Differential expression of complement regulatory proteins on subpopulations of human trophoblast cells.

    abstract：:Trophoblast cells forming the reactive interface between the mother and her semiallogeneic fetus risk attack by cellular and humoral elements of the maternal immune system. Biochemical, molecular, and immunohistologic studies have identified membrane cofactor protein (MCP) and decay accelerating factor (DAF) on tropho...

    journal_title：Journal of reproductive immunology

    pub_type： 杂志文章

    doi：10.1016/0165-0378(91)90036-p

    authors： Hsi BL,Hunt JS,Atkinson JP

    更新日期：1991-04-01 00:00:00