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Peripheral K cells in normal human pregnancy: decrease during pregnancy and increase after delivery.

Abstract：

:Peripheral blood levels of K cells were measured in normal pregnant and post-partum women by a plaque-forming cell technique that detects K cells on the basis of their activity of antibody-dependent cell-mediated cytotoxicity (ADCC). Peripheral K cells decreased throughout normal pregnancy (n = 46; 7.8 +/- 3.4%, P less than 0.01; 0.13 +/- 0.08 X 10(9)/l, P less than 0.001) and increased in the post-partum period (n = 17; 14.2 +/- 6.1%, P less than 0.05; 0.32 +/- 0.20 X 10(9)/l, P less than 0.01) in comparison with those in normal non-pregnant controls (n = 29; 10.5 +/- 4.2%; 0.20 +/- 0.09 X 10(9)/l). These findings suggest that a decrease of K cells during pregnancy may contribute in part to maternal acceptance of the fetal allograft and that the post-partum increase of K cells may represent a post-partum increase of cell-mediated cytotoxicity, which may contribute to natural defense against puerperal infection.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Asari S,Iwatani Y,Amino N,Tanizawa O,Miyai K

doi

10.1016/0165-0378(89)90042-9

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

31-7

issue

1

eissn

0165-0378

issn

1872-7603

pii

0165-0378(89)90089-2

journal_volume

15

pub_type

杂志文章

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