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A monoclonal antibody which detects a cell surface antigen on murine embryonal carcinoma and early mouse embryo stages may recognize a carbohydrate determinant involving alpha-linked galactose.

Abstract：

:A rat monoclonal antibody (5D4) apparently specific for murine embryonal carcinoma cells and cells of the pre-implantation embryo is described. It does not react with differentiated cells from a variety of different tumours and tissues of the mouse. Biochemical studies show that the molecules that carry 5D4 antigen are resistant to protease digestion on the cell surface but susceptible to procedures which affect carbohydrate structure. It is likely that this antibody detects a carbohydrate bearing determinant which may include an alpha-linked galactose residue.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Stern PL,Gilbert P,Heath JK,Furth M

doi

10.1016/0165-0378(83)90012-8

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

145-60

issue

3

eissn

0165-0378

issn

1872-7603

pii

0165-0378(83)90012-8

journal_volume

5

pub_type

杂志文章

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