Abstract：
:Autologous anti-horseradish peroxidase antibody has been localized in pregnant rats at various levels through placental membranes en passage to fetal circulation. The antibody was complexed in situ with the antigen and the resulting complex was made visible electron microscopically by immunohistochemical techniques. Visceral yolk-sac membranes from fetuses during the last half of gestation, viz. at 12, 17, and 22 days gestation, were so examined; differences were noted in the localization of cytochemical reaction product at increasing gestational ages. In yolk-sac endodermal epithelium at 12 days, the product was identified on receptor areas at the free surface of the epithelium, in a system of endocytosed clathrin-coated vesicles, or endosomes, within a closely related apical canalicular system, and stored in subapical vacuoles. Uptake and storage appeared markedly reduced in membranes taken at 17 days and was least apparent at 22 days (the day before term). Moreover, the product of antibody localization was not identified in the apical canaliculi at the two later stages. It is believed that most antibody had been hydrolyzed by these later stages. However, at the latest stage, reaction product also was identified in small vesicles in the basal cytoplasm of the endodermal epithelium and in the endothelium of vitelline (i.e., fetal) capillaries. These morphological results suggest that during the latter half of pregnancy antibody is absorbed; it is stored and hydrolyzed early on, and is transferred to fetal circulation only near term, a conclusion in close accord with what is known physiologically about prenatal transmission of immunity in this species.
journal_name
J Reprod Immunoljournal_title
Journal of reproductive immunologyauthors
Jollie WPdoi
10.1016/0165-0378(85)90057-9subject
Has Abstractpub_date
1985-05-01 00:00:00pages
261-74issue
3eissn
0165-0378issn
1872-7603pii
0165-0378(85)90057-9journal_volume
7pub_type
杂志文章abstract：:During the past 40 years, polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants and nearly all women have some level of exposure. PBDEs have been isolated from amniotic fluid and cord plasma indicating vertical transmission; however, their effects on pregnancy outcome are largely unknown. Th...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2014.11.002
更新日期：2015-02-01 00:00:00
abstract：:Tolerance to the developing fetus is thought to be accomplished through the action of several molecules that are able to modulate the maternal immune response. Among several mechanisms involved in pregnancy maintenance, progesterone-induced immunomodulation, asymmetric antibody (AAb) production, indoleamine 2,3-dioxyg...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2008.11.002
更新日期：2009-01-01 00:00:00
abstract：:Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a grea...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(94)90013-2
更新日期：1994-08-01 00:00:00
abstract：:It is self-evident that infection and inflammation in the reproductive tract can inhibit male fertility, but the observation that fertility may also be compromised by systemic inflammation and disease is more difficult to explain. Recent studies implicating microbial pattern-recognition receptors, such as the Toll-lik...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2011.01.010
更新日期：2011-03-01 00:00:00
abstract：:The association of persistent presence of circulating antiphospholipid antibodies and thromboembolic events, (recurrent) pregnancy loss or both is termed antiphospholipid syndrome. Pregnancies in women with the syndrome should be regarded as at high-risk for complications. Optimal management consisting of close follow...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章,评审
doi：10.1016/j.jri.2006.12.003
更新日期：2008-01-01 00:00:00
abstract：:The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution a...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2017.10.043
更新日期：2018-02-01 00:00:00
abstract：:Pre-eclampsia (PE) remains the leading cause of pregnancy-associated mortality and morbidity, urging the need for a better understanding of its aetiology and pathophysiological progression. A key characteristic of PE is a systemic, exaggerated, inflammatory condition involving abnormal cytokine levels in serum, altere...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2014.02.004
更新日期：2014-06-01 00:00:00
abstract：:We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/s0165-0378(99)00041-8
更新日期：1999-11-01 00:00:00
abstract：:Testicular macrophages (TMs) are important contributors to the response of the testis to infection, as well as the regulation of spermatogenesis, steroidogenesis and other homeostatic functions of the testis. The TMs are the largest population of immune cells in a region of tight immunoregulation, where both innate an...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章,评审
doi：10.1016/j.jri.2013.01.001
更新日期：2013-04-01 00:00:00
abstract：:Seven monoclonal antibodies (MAs) generated against porcine zona pellucida glycoprotein, ZP3 (comprising both ZP3 alpha and ZP3 beta) were characterized for their specificities to ZP3 alpha (MA 7 and MA 28) or ZP3 beta (MA 1, MA 2, MA 10, MA 27 and MA 30) and their relative affinities in competitive ELISA. Among the s...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(93)90047-l
更新日期：1993-04-01 00:00:00
abstract：:Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regula...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2014.04.001
更新日期：2014-12-01 00:00:00
abstract：:Since the discovery of non-coding RNAs, several families of small regulatory molecules have been described including small nucleolar RNAs, piwi-interacting RNAs and microRNAs (miRNAs). MiRNAs are small single-stranded RNA molecules which play an important role in the regulation of gene expression at the transcriptiona...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章,评审
doi：10.1016/j.jri.2011.01.004
更新日期：2011-03-01 00:00:00
abstract：:This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVI...
journal_title：Journal of reproductive immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jri.2015.01.008
更新日期：2015-06-01 00:00:00
abstract：:This study has assessed the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine administered to intact domestic cats. Fifteen kittens, 8-9 weeks of age, were allocated to three unequal treatment groups: group 1, 1 male control cat; group 2, 5 females administered 10 microg of GnR...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2004.08.004
更新日期：2004-12-01 00:00:00
abstract：:Trophoblast cells forming the reactive interface between the mother and her semiallogeneic fetus risk attack by cellular and humoral elements of the maternal immune system. Biochemical, molecular, and immunohistologic studies have identified membrane cofactor protein (MCP) and decay accelerating factor (DAF) on tropho...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(91)90036-p
更新日期：1991-04-01 00:00:00
abstract：:The central role of inflammatory processes in labour and delivery is now well-recognised. However, the biomolecular, immunological and endocrine mechanisms involved in the labour process, and the clinical manifestations of inflammation in pregnancy, are complex, variable and modulated by factors such as aetiology, eth...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章,评审
doi：10.1016/j.jri.2017.12.004
更新日期：2018-02-01 00:00:00
abstract：:Sperm antigens are being sought for the development of prototype contraceptive vaccines. For vaccine-induced antisperm antibodies to inhibit the function of viable sperm, target antigens must be expressed on the sperm surface before, during or after the acrosome reaction. The purpose of this study was to develop an ap...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(91)90019-m
更新日期：1991-05-01 00:00:00
abstract：:This study examines the distribution of two carbohydrate determinants recognized by monoclonal antibodies EMA-1 and EMA-6 on cells in culture, adult mouse tissues and day 0-7 embryos, and provides partial biochemical characterization of the molecules carrying the determinants for EMA-1 on embryonal carcinoma cells. Bo...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(87)90069-6
更新日期：1987-02-01 00:00:00
abstract：:63 female rhesus monkeys were actively immunized against the beta-subunit of ovine luteinizing hormone (oLH beta). 75% of these monkeys developed antibodies which were sufficiently high to induce infertility. We report here the in vivo neutralizing potencies of anti-oLH beta antisera from 14 monkeys and the correlatio...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(83)90235-8
更新日期：1983-07-01 00:00:00
abstract：:The present investigation was undertaken to study the association between placental apoptosis and pre-eclampsia, discriminating between pre-eclamptic pregnancies with appropriate-, and small-for-gestational-age (SGA), infants. Twenty pregnancies with pre-eclampsia and SGA (birth weight at or below -2 standard deviatio...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2003.10.001
更新日期：2004-02-01 00:00:00
abstract：:An iso-antigen has been isolated from tritium-labelled human spermatozoa by detergent solubilization, lectin affinity chromatography and indirect immunoprecipitation using human iso-antisera. Isolated material was characterized by SDS-polyacrylamide gel electrophoresis. With these iso-antisera it was possible to isola...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(83)90020-7
更新日期：1983-01-01 00:00:00
abstract：:Monoclonal antibodies (MAb) were raised against a testicular membrane fraction from 18-day post coitum (p.c.) rat testes. One antibody, designated 4B6.3E10 (mu, kappa), was obtained which specifically reacted with gonocytes in the fetal testis. No significant cross-reactivity with other tissues from the 18-day p.c. em...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(93)90030-l
更新日期：1993-01-01 00:00:00
abstract：:Viviparity has many evolutionary advantages but brings with it the problem of the semi-allogeneic foetus having to coexist with the mother for the duration of pregnancy. In species with haemochorial placentation this problem is particularly evident as foetal trophoblast cells are extensively intermingled with maternal...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章,评审
doi：10.1016/j.jri.2012.10.006
更新日期：2013-03-01 00:00:00
abstract：:Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the pr...
journal_title：Journal of reproductive immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jri.2016.02.002
更新日期：2016-04-01 00:00:00
abstract：:Alloimmunization therapy using the partner's leukocytes has been reported to be effective in preventing the failure of pregnancy in patients who have suffered RSA of unknown cause. After alloimmunization, several investigators have reported the presence of blocking factors (BF) in women with successful pregnancies in ...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/s0165-0378(99)00021-2
更新日期：1999-09-01 00:00:00
abstract：:A monoclonal anti-human sperm antibody (Mab 1A1) has been produced by fusion of myeloma cells with splenocytes from a BALB/c mouse immunized with in vitro capacitated human spermatozoa. Immunofluorescence studies with Mab 1A1 show that it recognizes an antigen(s) (Ag 1A1) which is located in the acrosome of human sper...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(91)90039-s
更新日期：1991-04-01 00:00:00
abstract：:The tissue distribution, molecular weight, and biochemical nature of an antigen detected by a mouse monoclonal antibody designated 283D3 and raised against rabbit visceral yolk sac endodermal cells, has been investigated. The antigen is located on the luminal side of apical tubules and large sub-apical vesicles in rab...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/0165-0378(93)90046-k
更新日期：1993-04-01 00:00:00
abstract：:Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammat...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2018.07.006
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Elongation factor Tu GTP binding domain containing 2 (EFTUD2) is an alternative splicing factor that modulates cell differentiation and activation processes. EFTUD2 is known to modulate immune responses and mutation of the EFTUD2-gene lead to fetal malformation. Little is known about its expression and role ...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/j.jri.2020.103149
更新日期：2020-08-01 00:00:00
abstract：:Development of a vaccine(s) based on sperm antigens represents a promising approach to contraception. The utility of an antigen in immunocontraception is contingent upon sperm/testis-specificity and its involvement in the fertilization process. Since, the sperm-zona pellucida (ZP) recognition and binding constitutes t...
journal_title：Journal of reproductive immunology
pub_type： 杂志文章
doi：10.1016/s0165-0378(01)00094-8
更新日期：2002-01-01 00:00:00
