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First trimester human trophoblast expresses both interferon-gamma and interferon-gamma-receptor.

Abstract：

:Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a great number of IFN-gamma receptors (IFN-gamma R) have been purified from human placenta, we have examined the relative distribution of IFN-gamma and IFN-gamma R in human placental tissues at different stages of pregnancy. By using immunohistochemical analysis and monoclonal antibodies, it was found that IFN-gamma expression is intense in the first trimester but almost imperceptible at term, whereas the expression of IFN-gamma R is present at both stages of pregnancy. For both lymphokine and receptor, the most intense expression was observed in villous syncytiotrophoblast and in extravillous interstitial trophoblast. From these results it appears that the expression of IFN-gamma R in trophoblast is related to the presence of the lymphokine in the early phase of gestation but not later. On this basis, it can be argued that IFN-gamma exerts its functional role via an autocrine and/or a paracrine loop mainly during the first trimester.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Paulesu L,Romagnoli R,Cintorino M,Ricci MG,Garotta G

doi

10.1016/0165-0378(94)90013-2

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

37-48

issue

1

eissn

0165-0378

issn

1872-7603

pii

0165-0378(94)90013-2

journal_volume

27

pub_type

杂志文章

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