Abstract:
AIM:Th17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease. METHODS:The percentage of Th17 cells among T helper lymphocytes was determined in the PF and peripheral blood (PB) of patients with endometriosis and in the control group by flow cytometry using monoclonal antibodies: anti-CD-4-FITC, anti-CD-3-PE/Cy5, and anti-IL-17A-PE. RESULTS:Th17 percentage is increased in PF in comparison with PB in both endometriotic patients and in the control group. In severe endometriosis, the percentage of Th17 cells in PF was higher than with early (I/II stage) endometriosis. A positive correlation between the percentage of Th17 cells in PF and the white blood cell count in PB was found in patients with endometriosis. CONCLUSION:Targeting the activity of PF Th17 cells may have an influence on the proliferation of ectopic tissue and clinical manifestations of the disease.
journal_name
J Reprod Immunoljournal_title
Journal of reproductive immunologyauthors
Gogacz M,Winkler I,Bojarska-Junak A,Tabarkiewicz J,Semczuk A,Rechberger T,Adamiak Adoi
10.1016/j.jri.2016.04.289subject
Has Abstractpub_date
2016-09-01 00:00:00pages
39-44eissn
0165-0378issn
1872-7603pii
S0165-0378(16)30033-Xjournal_volume
117pub_type
杂志文章abstract::Placental culture supernatants (PS) obtained from various mouse crossbreedings were added to mouse IgG1 hybridoma cultures producing anti-DNP antibodies. The quantity of monoclonal antibody (mAb) produced, the nature of these antibodies and the proliferation of the hybridoma cells were studied. It was observed that th...
journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
pub_type: 杂志文章
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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journal_title:Journal of reproductive immunology
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