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Soluble HLA-G molecules in follicular fluid: a tool for oocyte selection in IVF?

Abstract：

:Currently, different approaches are used to select oocytes for in vitro fertilization (IVF) procedures, but they do not assure a significant association with the pregnancy outcome. Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker of elevated implantation rate, we have investigated the presence of soluble HLA-G molecules in 50 follicular fluids (FFs). The results have shown soluble HLA-G antigens (sHLA-G) in 19/50 (38%) FFs. Furthermore, we have related the presence of sHLA-G molecules in FFs to detection of the soluble antigens in culture supernatants of the corresponding fertilized oocyte, evidencing a significant relationship (p=1.3 x 10(-6); Fisher exact p-test). Specific ELISA and Western blot approaches identified both HLA-G5 and soluble HLA-G1 molecules in FFs while immunocytochemical analysis indicated polymorphonuclear-like and granulosa cells as responsible for production of sHLA-G1 and HLA-G5 molecules. In contrast, only sHLA-G1 antigens were detected in culture supernatants of fertilized oocytes. Overall, these results suggest a role for sHLA-G molecules in the ovulatory process and propose the FFs analysis for sHLA-G molecule presence as a useful tool for oocyte selection in IVF.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Rizzo R,Fuzzi B,Stignani M,Criscuoli L,Melchiorri L,Dabizzi S,Campioni D,Lanza F,Marzola A,Branconi F,Noci I,Baricordi OR

doi

10.1016/j.jri.2007.02.005

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

133-42

issue

1-2

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(07)00059-9

journal_volume

74

pub_type

杂志文章

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