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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

Abstract：

BACKGROUND:Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS:Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP. RESULTS:In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = - .568, 95%CI - .942 to - .194; p = .003) and higher BMI (β = - .086, 95%CI - .128 to - .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = - 1.033, 95%CI - 1.762 to - .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%). CONCLUSIONS:The findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.

journal_name

BMC Med

journal_title

BMC medicine

authors

Luo Q,Zhang L,Huang CC,Zheng Y,Kanen JW,Zhao Q,Yao Y,Quinlan EB,Jia T,Banaschewski T,Bokde ALW,Bromberg U,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Martinot MP,Nees F,Orfanos

doi

10.1186/s12916-020-01743-2

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

278

issue

issn

1741-7015

pii

10.1186/s12916-020-01743-2

journal_volume

pub_type

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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.