Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases.

abstract：BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...

journal_title：BMC medicine

authors： Donath X,Saint-Martin C,Dubois-Laforgue D,Rajasingham R,Mifsud F,Ciangura C,Timsit J,Bellanné-Chantelot C,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2019-07-11 00:00:00

abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...

journal_title：BMC medicine

authors： Sabin CA

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...

journal_title：BMC medicine

authors： Bruce R,Chauvin A,Trinquart L,Ravaud P,Boutron I

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...

journal_title：BMC medicine

authors： Akhtar M,Kraemer MUG,Gardner LM

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical...

journal_title：BMC medicine

authors： Lanas A,Garcia-Tell G,Armada B,Oteo-Alvaro A

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

journal_title：BMC medicine

authors： Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

更新日期：2009-10-05 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis...

journal_title：BMC medicine

authors： Pandie S,Peter JG,Kerbelker ZS,Meldau R,Theron G,Govender U,Ntsekhe M,Dheda K,Mayosi BM

更新日期：2014-06-18 00:00:00

abstract：:The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscit...

journal_title：BMC medicine

authors： Myburgh J,Finfer S

更新日期：2013-03-14 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：:Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...

journal_title：BMC medicine

authors： Bower P

更新日期：2014-12-08 00:00:00

abstract：:Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....

journal_title：BMC medicine

authors： Mitsikostas DD,Rapoport AM

更新日期：2015-11-10 00:00:00

abstract：:In this podcast, we talk to Dr Sunil Verma about the evolution of HER2 as a therapeutic target in breast cancer, and about how targeted therapy has revolutionized breast cancer treatment. We also discuss new agents in clinical development and the ways in which advances in treating HER2-positive breast cancer can be us...

journal_title：BMC medicine

authors： Verma S

更新日期：2014-08-12 00:00:00

abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...

journal_title：BMC medicine

authors： Lundin KE

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Medical apps are widely available, increasingly used by patients and clinicians, and are being actively promoted for use in routine care. However, there is little systematic evidence exploring possible risks associated with apps intended for patient use. Because self-medication errors are a recognized source...

journal_title：BMC medicine

authors： Huckvale K,Adomaviciute S,Prieto JT,Leow MK,Car J

更新日期：2015-05-06 00:00:00

abstract：:Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of t...

journal_title：BMC medicine

authors： Castiblanco J,Arcos-Burgos M,Anaya JM

更新日期：2013-09-04 00:00:00

abstract：:The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some settings, and scores are increasingly being employed to define Mediterranean diet adherence in epidemiological st...

journal_title：BMC medicine

authors： Trichopoulou A,Martínez-González MA,Tong TY,Forouhi NG,Khandelwal S,Prabhakaran D,Mozaffarian D,de Lorgeril M

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:In July 2014, an outbreak of Ebola virus disease (EVD) started in Pujehun district, Sierra Leone. On January 10th, 2015, the district was the first to be declared Ebola-free by local authorities after 49 cases and a case fatality rate of 85.7%. The Pujehun outbreak represents a precious opportunity for impro...

journal_title：BMC medicine

authors： Ajelli M,Parlamento S,Bome D,Kebbi A,Atzori A,Frasson C,Putoto G,Carraro D,Merler S

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...

journal_title：BMC medicine

authors： Meyer AC,Drefahl S,Ahlbom A,Lambe M,Modig K

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：:The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...

journal_title：BMC medicine

authors： Tomori O

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistently tyrosine-705 phosp...

journal_title：BMC medicine

authors： Sonnenblick A,Brohée S,Fumagalli D,Vincent D,Venet D,Ignatiadis M,Salgado R,Van den Eynden G,Rothé F,Desmedt C,Neven P,Loibl S,Denkert C,Joensuu H,Loi S,Sirtaine N,Kellokumpu-Lehtinen PL,Piccart M,Sotiriou C

更新日期：2015-08-03 00:00:00

abstract：:The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...

journal_title：BMC medicine

authors： Moore DA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：:This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...

journal_title：BMC medicine

authors： BioMed Central.

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone (AVN), other) in patients undergoing primary total hip arthroplasty (THA). METHODS:We used prospec...

journal_title：BMC medicine

authors： Singh JA,Lewallen DG

更新日期：2013-09-24 00:00:00